Abstract:
:The benzodiazepine, lorazepam enhances the efficiency of local, inhibitory GABA(A) synapses in the cortex, which stabilize postsynaptic, excitatory activity by synchronizing their own discharges at around 40 Hz. Treatment with lorazepam has also been shown to adversely influence detection performance in perceptual tasks, suggesting a role for GABA(A)-mediated synchronization during visuo-perceptual organization. Consistent with these findings we report that reaction times to target stimuli were slower following lorazepam treatment. However, when targets followed presentation of a synchronized prime, presented within a flickering 40-Hz display matrix, the effects of priming were amplified relative to baseline and control conditions. We conclude that enhanced GABA(A)-induced inhibition enhances stimulus-evoked synchronization with differential effects upon mechanisms of perceptual segmentation and grouping.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Elliott MA,Becker C,Boucart M,Müller HJdoi
10.1097/00001756-200010200-00027subject
Has Abstractpub_date
2000-10-20 00:00:00pages
3403-7issue
15eissn
0959-4965issn
1473-558Xjournal_volume
11pub_type
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