Expression of nuclear factor erythroid 2-related factor 2 following traumatic brain injury in the human brain.

Abstract:

:Secondary brain injury imposes great effects on the prognosis of patients following traumatic brain injury (TBI). Accumulating evidence suggests that nuclear factor erythroid 2-related factor 2 (Nrf2) could play a neuroprotective role in experimental TBI models by regulating the expression of numerous antioxidant, anti-inflammatory, and neuroprotective proteins. However, whether Nrf2 is activated in patients following TBI is still unknown. In this study, human brain tissues were obtained during surgery from patients suffering from TBI. The purpose of this study was to investigate the expression of Nrf2 and Nrf2-regulated gene products, NAD(P)H quinine oxidoreductase 1, and glutathione S-transferase in human injured brain tissue after TBI. Our results revealed that the nuclear level of Nrf2 was significantly increased in injured brain tissues, whereas the cytoplasmic level of Nrf2 was markedly decreased. In addition, the expression of NAD(P)H quinine oxidoreductase 1 and glutathione S-transferase was significantly upregulated. Nrf2 may be activated and confer neuroprotection against secondary brain injury following TBI. Therefore, Nrf2 could serve as a promising molecular target for the treatment of TBI.

journal_name

Neuroreport

journal_title

Neuroreport

authors

He Y,Yan H,Ni H,Liang W,Jin W

doi

10.1097/WNR.0000000000001205

subject

Has Abstract

pub_date

2019-03-20 00:00:00

pages

344-349

issue

5

eissn

0959-4965

issn

1473-558X

journal_volume

30

pub_type

杂志文章
  • Muscarinic cholinoceptive reticular mechanisms and parabrachial neuron discharge: a novel experimental approach.

    abstract::This study examined the hypothesis that cholinergic receptor mechanisms within the gigantocellular tegmental field (FTG) of the medial pontine reticular formation can cause state-dependent changes in the firing rates of parabrachial nuclear complex (PBNC) neurons. Using intact, unanesthetized cats, long-term recording...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199303000-00011

    authors: Gilbert KA,Lydic R

    更新日期:1993-03-01 00:00:00

  • Glutamate agonist activity: implications for antipsychotic drug action and schizophrenia.

    abstract::Antagonist action at dopamine D2 receptors appears to explain many, but not all of the effects of antipsychotic drugs. Because of the interactions of dopamine with glutamate, and the implication of the latter in the etiology of schizophrenia, possible effects of antipsychotic drugs on glutamate receptors were assessed...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:

    authors: Banerjee SP,Zuck LG,Yablonsky-Alter E,Lidsky TI

    更新日期:1995-12-15 00:00:00

  • Histamine H3-receptor activation inhibits dopamine synthesis in rat striatum.

    abstract::Unilateral 6-hydroxydopamine lesion to rat substantia nigra pars compacta resulted in a modest, but significant, decrease in the specific binding of N-alpha-[methyl-3H]histamine (19 +/- 5% reduction) to synaptosomal membranes from ipsilateral striata. Dopamine synthesis was assessed in striatal slices by determining [...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200001170-00032

    authors: Molina-Hernández A,Nuñez A,Arias-Montaño JA

    更新日期:2000-01-17 00:00:00

  • NK1 receptor and the ventral medulla of the rat: bulbospinal and catecholaminergic neurons.

    abstract::Bulbospinal C1 neurons are sympathoexcitatory and excited by substance P. However the substance P receptor (NK1 receptor), has been reported to be absent from the somata of C1 neurons. In this study, using double and triple labelling immunofluorescence and retrograde tracing, we provide evidence that the NK1 receptor ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200112040-00012

    authors: Makeham JM,Goodchild AK,Pilowsky PM

    更新日期:2001-12-04 00:00:00

  • Hippocampal, parahippocampal and occipital-temporal contributions to associative and item recognition memory: an fMRI study.

    abstract::The temporal lobe regions involved in memory retrieval were examined using fMRI. During an associative recognition test, participants made memory judgments about the study color of previously presented drawings of objects, and during item recognition tests they made old/new judgments about previously studied objects o...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200102120-00035

    authors: Yonelinas AP,Hopfinger JB,Buonocore MH,Kroll NE,Baynes K

    更新日期:2001-02-12 00:00:00

  • Superinduction of leptin mRNA in mouse hypothalamic neurons.

    abstract::In marked contrast to several other species, including rats and humans, leptin gene expression is undetectable in mouse brain. This unexpected finding may reflect unique energy regulation pathways in the mouse. We investigated possible mechanisms by which leptin (ob) gene expression is suppressed in mouse brain: (a) t...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e3283595709

    authors: Brown RE,Wilkinson DA,Wilkinson PM,Imran SA,Wilkinson M

    更新日期:2012-10-24 00:00:00

  • Role of exosomes induced by remote ischemic preconditioning in neuroprotection against cerebral ischemia.

    abstract::Remote ischemic preconditioning (RIPC) is an effective regimen for neuroprotection in ischemic stroke. Exosomes are extracellular vesicles released into the blood, where they can transfer signals throughout the body. Several studies have demonstrated that RIPC leads to many changes in circulating exosomes. However, th...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000001280

    authors: Li Y,Ren C,Li H,Jiang F,Wang L,Xia C,Ji X

    更新日期:2019-08-14 00:00:00

  • Recovery of the nasal field loss in esotropic cats after section of the optic chiasm.

    abstract::It is assumed that in esotropic cats the behavioural suppression of the nasal field reflects inhibition of the input conveyed through the temporal retinal afferents of the strabismic eye. We hypothesized that inhibition underlying the field defect might be actively operated by interocular competitive mechanisms. If so...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199506090-00028

    authors: Di Stefano M,Gargini C

    更新日期:1995-06-19 00:00:00

  • Reorganization of human cortical motor output maps following traumatic forearm amputation.

    abstract::We report the results of serial transcranial magnetic stimulation mapping of cortical motor outputs to the face and upper extremity in a subject studied before and repeatedly after traumatic amputation of the right arm immediately below the elbow. The results of the mapping studies illustrate the time course of plasti...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199609020-00002

    authors: Pascual-Leone A,Peris M,Tormos JM,Pascual AP,Catalá MD

    更新日期:1996-09-02 00:00:00

  • Nerve cell death induced in vivo by kainic acid and quinolinic acid does not involve apoptosis.

    abstract::We investigated whether in vivo excitotoxicity was mediated by a mechanism of programmed cell death called apoptosis. Neurotoxic doses of kainic acid (1.2 nmol) and quinolinic acid (120 nmol) were unilaterally injected in the dorsal hippocampus of anesthetized rats. Eight or 16 h later the animals were killed and DNA ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199111000-00004

    authors: Ignatowicz E,Vezzani AM,Rizzi M,D'Incalci M

    更新日期:1991-11-01 00:00:00

  • Glycine transporters (glycine transporter 1 and glycine transporter 2) are expressed in retina.

    abstract::The amino acid glycine is an inhibitory neurotransmitter in the spinal cord, brain stem, and vertebrate retina. The effective synaptic concentrations of glycine are regulated by at least two transporters: glycine transporter 1 and glycine transporter 2. Here, we show retinal expression of glycine transporter 1 by in-s...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e32830a9618

    authors: Peña-Rangel MT,Riesgo-Escovar JR,Sánchez-Chávez G,Salceda R

    更新日期:2008-08-27 00:00:00

  • Progesterone receptor immunoreactivity in the brains of ovariectomized aged rats.

    abstract::We examined the induction of progesterone receptor-immunoreactive (PR-ir) cells by estrogen in the rat preoptic area and ventromedial hypothalamic nucleus. Ovariectomized young (3-month-old) and old (24-month-old) female rats were treated with estrogen or cholesterol for 4 days. Estrogen significantly increased PR-ir ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e32833c5b6f

    authors: Furuta M,Fukushima A,Chiba S,Sano A,Akema T,Kimura F,Funabashi T

    更新日期:2010-08-04 00:00:00

  • Long-term disuse of the hand affects motor imagery ability in patients with complete brachial plexus palsy.

    abstract::The purpose of this study was to examine motor imagery ability in patients with peripheral nerve disorder using the hand mental rotation task. Five patients with left total avulsion brachial plexus palsy (BPP) and 16 healthy age-matched adults participated in this study. The mean±SD time from the injury was 103.6±49.7...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000001229

    authors: Date S,Kurumadani H,Yoshimura M,Fukae A,Onishi K,Hayashi J,Shinomiya R,Sunagawa T

    更新日期:2019-04-10 00:00:00

  • Phospholipase A2-induced changes in AMPA receptor: an autoradiographic study.

    abstract::The expression of long-term potentiation and learning of a classical conditioning task increase [3H]-AMPA binding in hippocampus. Phospholipase A2 (PLA2) has been proposed to underly these changes, as PLA2 treatment of membrane preparations increases the affinity of AMPA receptors for agonists. We demonstrate here tha...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:

    authors: Tocco G,Massicotte G,Standley S,Thompson RF,Baudry M

    更新日期:1992-06-01 00:00:00

  • High frequency repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex in schizophrenic patients.

    abstract::Repetitive transcranial magnetic stimulation (rTMS) has been tried therapeutically in major depression. In order to investigate the therapeutic efficacy of rTMS in psychotic patients, 12 participants (four women, eight men) with schizophrenia according to DSM-IV criteria, aged 25 to 63 years (mean (+/-s.d) 40.4+/-11.0...

    journal_title:Neuroreport

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00001756-200012180-00022

    authors: Rollnik JD,Huber TJ,Mogk H,Siggelkow S,Kropp S,Dengler R,Emrich HM,Schneider U

    更新日期:2000-12-18 00:00:00

  • Resiliency of cortical neural networks against cascaded failures.

    abstract::Network tools have been extensively applied to study the properties of brain functional and anatomical networks. In this paper, resiliency of Caenorhabditis elegans cortical networks against cascaded failures is studied. To this end, directed network formed by chemical connections and undirected network formed by elec...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000421

    authors: Jalili M

    更新日期:2015-08-19 00:00:00

  • Denervation impairs cutaneous microvascular function and blister healing in the rat hindlimb.

    abstract::Skin sensory nerve nocifensor functions were investigated non-invasively in rats by measuring neurogenic inflammation and blister healing-rate after unilateral hindlimb denervation. Axon reflexes were evoked by transdermal iontophoresis of acetylcholine (ACh) or noxious electrical stimulation (TNS). Sodium nitroprussi...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199305000-00001

    authors: Carr RW,Delaney CA,Westerman RA,Roberts RG

    更新日期:1993-05-01 00:00:00

  • Ibogaine fails to reduce naloxone-precipitated withdrawal in the morphine-dependent rat.

    abstract::Because of anecdotal reports in which ibogaine eliminates opioid withdrawal symptoms in humans, we studied this phenomenon in the rat model. Ibogaine (5, 10, 20 and 40 mg kg-1, s.c.) was administered 15 min before naloxone (0.5 mg kg-1, s.c.) in morphine dependent rats (3 days after the s.c. implantation of a 75 mg mo...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199009000-00005

    authors: Sharpe LG,Jaffe JH

    更新日期:1990-09-01 00:00:00

  • Coexistence of cholinergic and somatostatin receptors on astrocytes of rat CNS.

    abstract::Electrophysiological studies have shown that somatostatin (SOM; 10(-8) and 10(-7) M) causes a hyperpolarization of the majority of astrocytes in explant cultures of rat spinal cord and cortex. When SOM and the cholinergic agonists muscarine and nicotine (10(-6) M) were tested on the same cell, all three compounds prod...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199407000-00015

    authors: Hösli L,Hösli E,Winter T,Stauffer S

    更新日期:1994-07-21 00:00:00

  • Regulation of serotonin release in the Syrian hamster intergeniculate leaflet region.

    abstract::In mammals, the thalamic intergeniculate leaflet (IGL) conveys behavioral (non-photic) phase-resetting information to the circadian clock of the suprachiasmatic nucleus. Here we report a 24 h fluctuation in in vivo serotonin release in the hamster IGL region, peaking at night. Novel wheel exposure at midday, a stimulu...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200401190-00021

    authors: Grossman GH,Farnbauch L,Glass JD

    更新日期:2004-01-19 00:00:00

  • Dose-response of rt-PA and its combination with aspirin in a rat embolic stroke model.

    abstract::The efficacy and safety of thrombolysis with different dose regimens of recombinant tissue plasminogen activator (rt-PA) and its combination with aspirin was tested in an embolic stroke model. In rats the carotid territory was embolized with a single clot formed in a polyethylene tube and washed with saline. Fifteen m...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199210000-00027

    authors: Overgaard K,Sereghy T,Pedersen H,Boysen G

    更新日期:1992-10-01 00:00:00

  • An implantable device for neuropsychiatric rehabilitation by chronic deep brain stimulation in freely moving rats.

    abstract::Successful practice of clinical deep brain stimulation (DBS) calls for basic research on the mechanisms and explorations of new indications in animals. In the article, a new implantable, single-channel, low-power miniature device is proposed, which may transmit pulses chronically into the brain nucleus of freely movin...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000727

    authors: Liu H,Wang C,Zhang F,Jia H

    更新日期:2017-02-08 00:00:00

  • PSD95 protein level rises in murine somatosensory cortex after sensory training.

    abstract::Proteins of the postsynaptic density are implicated in mechanisms of synaptic plasticity. We examined involvement of PSD95 and alphaCaMkII in learning-dependent plastic changes of representational maps in somatosensory cortex of mice. The barrel cortex of mice was examined following a 3 day long classical conditioning...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200109170-00030

    authors: Skibinska A,Lech M,Kossut M

    更新日期:2001-09-17 00:00:00

  • Primary auditory cortex activation by visual speech: an fMRI study at 3 T.

    abstract::Recent studies have yielded contradictory evidence on whether visual speech perception (watching articulatory gestures) can activate the human primary auditory cortex. To circumvent confounds due to inter-individual anatomical variation, we defined our subjects' Heschl's gyri and assessed blood oxygenation-dependent s...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200502080-00010

    authors: Pekkola J,Ojanen V,Autti T,Jääskeläinen IP,Möttönen R,Tarkiainen A,Sams M

    更新日期:2005-02-08 00:00:00

  • Wisteria floribunda agglutinin-labelled nets surround parvalbumin-containing neurons.

    abstract::Net-like structures surrounding several types of neurones contain glycoconjugates which are detectable by lectins specific for N-acetylgalactosamine. Wisteria floribunda agglutinin (WFA) was introduced as a further marker for the visualization of such perineuronal nets, which were also revealed in regions of the rat b...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199210000-00012

    authors: Härtig W,Brauer K,Brückner G

    更新日期:1992-10-01 00:00:00

  • Cell density and exogenous CNTF affect CNTF mRNA levels in glial cell cultures.

    abstract::Regulation of CNTF mRNA was investigated in primary cortical astrocytes cultured from newborn rats and in C6 glioma cells. Northern blot analysis indicated that semi-confluent astrocyte cell cultures. CNTF added to confluent astrocyte cultures down-regulated CNTF message in a dose-dependent fashion. In contrast, when ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199410000-00026

    authors: Meyer V,Unsicker K

    更新日期:1994-10-03 00:00:00

  • Gene expression in the geniculate induced by a nonphotic circadian phase shifting stimulus.

    abstract::We examined the effect of a nonphotic stimulus (running in a novel wheel) on the induction of Fos-related proteins in the two well-established neural components of the circadian clock: the suprachiasmatic nucleus (SCN) and the intergeniculate leaflet (IGL) of the lateral geniculate complex. There was no induction of F...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199207000-00007

    authors: Janik D,Mrosovsky N

    更新日期:1992-07-01 00:00:00

  • Distinct anxiogenic/anxiolytic effects exerted by the hamster lateral amygdalar nucleus injected with ORX-A or ORX-B in the presence of a GABAergic agonist.

    abstract::Recently, there has been growing interest in the neurobiological role of some amygdalar neuromediators, such as GABA and orexins (ORX), that are responsible for stressful behaviors. Infusion of the major fear-related and panic-related basolateral amygdalar station, the lateral nucleus, with ORX-A and ORX-B, alone or i...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000213

    authors: Avolio E,Biasone A,Mele M,Alò R

    更新日期:2014-08-20 00:00:00

  • Differential expression of Group I metabotropic glutamate receptors in motoneurons at low and high risk for degeneration in ALS.

    abstract::Glutamate excitotoxicity has been suggested to play a role in amyotrophic lateral sclerosis (ALS), yet it remains unclear why some groups of motoneurons (MNs) are more vulnerable to degeneration than others. Our aim was to compare, in normal adult rats, the expression of Group I metabotropic glutamate receptors (mGluR...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200107030-00027

    authors: Laslo P,Lipski J,Funk GD

    更新日期:2001-07-03 00:00:00

  • Enhanced expression of I-kappaB with neurofibrillary pathology in Alzheimer's disease.

    abstract::Inflammatory and immune responses are known to be involved in the pathogenesis of Alzheimer's disease (AD). NF-kappaB is a major transcription factor that plays a central role in the inflammatory and immune responses and is regulated by I-kappaB through an autoregulatory feedback system. Southwestern immunohistochemis...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200108280-00011

    authors: Yoshiyama Y,Arai K,Hattori T

    更新日期:2001-08-28 00:00:00