Abstract:
:Antagonist action at dopamine D2 receptors appears to explain many, but not all of the effects of antipsychotic drugs. Because of the interactions of dopamine with glutamate, and the implication of the latter in the etiology of schizophrenia, possible effects of antipsychotic drugs on glutamate receptors were assessed in the present experiments. These studies showed that, at clinically relevant concentrations, the conventional neuroleptic haloperidol and the atypical antipsychotic clozapine had potent augmenting influences on the NMDA receptor. These data suggest that unique action at glutamate receptors may contribute to antipsychotic efficacy and emphasize the potential importance of glutamatergic dysfunction in the etiology of schizophrenia.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Banerjee SP,Zuck LG,Yablonsky-Alter E,Lidsky TIsubject
Has Abstractpub_date
1995-12-15 00:00:00pages
2500-4issue
18eissn
0959-4965issn
1473-558Xjournal_volume
6pub_type
杂志文章相关文献
NEUROREPORT文献大全abstract::Calsenilin, a multifunctional Ca2+-binding protein, has been identified as an Alzheimer's disease-associated presenilin interactor. Here, we investigated the histochemical localization of calsenilin and its expression levels in the brains of sporadic Alzheimer's disease. Both messenger RNA and protein expression of ca...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200504040-00007
更新日期:2005-04-04 00:00:00
abstract::Transient receptor potential vanilloid 1 (TRPV1) channel has been found to be expressed in a variety of tissues over the last few years, including the central nervous system (CNS). However, the distribution of TRPV1 in the CNS remains a controversial question. Here, we reveal that the expression of TRPV1 can be detect...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000105
更新日期:2014-04-16 00:00:00
abstract::Event-related brain potential studies show that negative feedback in guessing tasks elicits a medial frontal negativity. Most theory and experimentation concerning this feedback-related negativity (FRN) has assumed that the FRN has little relationship to the perceptual characteristics of the feedback. This study chall...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32832a3250
更新日期:2009-04-22 00:00:00
abstract::We present the first assessment of motion vision in childhood autism. Postural reactivity to visually perceived motion was measured in five autistic children and 12 normal controls of the same chronological age. Anteroposterior as well as total body sway occurring on a force platform in response to movements in the vi...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199505300-00034
更新日期:1995-05-30 00:00:00
abstract::Plasminogen activator inhibitor-1 is a serpin that regulates the activities of plasminogen activators. However, its physiological roles in the CNS are incompletely understood. We have found that plasminogen activator inhibitor-1 has a novel biological function in the CNS: the contribution to survival of neurites on ne...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200404090-00024
更新日期:2004-04-09 00:00:00
abstract::The potent and selective AMPA receptor antagonist NBQX was tested for cytoprotective properties in an adult rat model of transient focal neocortical ischemia. Nineteen spontaneously hypertensive rats sustained 2 h of middle cerebral artery occlusion, followed by 22 h of recirculation. Ninety minutes following the onse...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199108000-00016
更新日期:1991-08-01 00:00:00
abstract::Repetitive transcranial magnetic stimulation (rTMS) has been tried therapeutically in major depression. In order to investigate the therapeutic efficacy of rTMS in psychotic patients, 12 participants (four women, eight men) with schizophrenia according to DSM-IV criteria, aged 25 to 63 years (mean (+/-s.d) 40.4+/-11.0...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00001756-200012180-00022
更新日期:2000-12-18 00:00:00
abstract::The terrestrial snail Helix lucorum is a promising model for molecular neurobiology since its central nervous system (CNS) is simple and contains many morphologically and functionally identified large neurones. Among these, the giant interneurones located in pleural and parietal ganglia are especially interesting beca...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199401000-00014
更新日期:1994-01-31 00:00:00
abstract::The functional organization of intrinsic connections in the cat motor cortex was examined by combining intracortical microstimulation with neuroanatomical tracers. After single injections of a dye into a cortical site from which wrist flexion was evoked, clusters of retrogradely labeled somata and of anterogradely lab...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199305000-00013
更新日期:1993-05-01 00:00:00
abstract::We previously reported that the methanol extract of Ashwagandha (roots of Dunal) induced dendrite extension in a human neuroblastoma cell line. In this study, we found that six of the 18 compounds isolated from the methanol extract enhanced neurite outgrowth in human neuroblastoma SH-SY5Y cells. Double immunostaining ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200210070-00005
更新日期:2002-10-07 00:00:00
abstract::It is well known that perceiving another person's body movements activates corresponding motor representations in an observer's brain, a process which appears to be imitative in nature. However, it is also true that simply imitating another person's action/s in many situations is not an effective or appropriate respon...
journal_title:Neuroreport
pub_type: 杂志文章,评审
doi:10.1097/WNR.0b013e3283630a66
更新日期:2013-08-07 00:00:00
abstract::BC200 is a long noncoding RNA expressed at high levels in the Alzheimer's disease (AD), and blocking of BC200 by siRNA is assumed to be an effective method for various disease therapy. We have established an AD cell model overexpressing amyloid β-peptide (Aβ)1-42 to observe the effects of BC200 on the cell viability a...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001057
更新日期:2018-09-05 00:00:00
abstract::Although citral, which is abundantly present in lemongrass, has various actions including antinociception, how citral affects synaptic transmission has not been examined as yet. Citral activates in heterologous cells transient receptor potential vanilloid-1, ankyrin-1, and melastatin-8 (TRPV1, TRPA1, and TRPM8, respec...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000518
更新日期:2016-02-10 00:00:00
abstract::We have used double quantum filtered (DQF) 23Na+ nuclear magnetic resonance (NMR) spectroscopy without shift reagents in order to monitor intracellular Na+ (Na+i) in a cortical brain slice preparation. The external Na+ (Na+o) signal was reduced by 95% by the DQF sequence compared with the directly observed 23Na+. The ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199302000-00006
更新日期:1993-02-01 00:00:00
abstract::We examined differences in brain activity in response to two types of mechanical stimulation, which have been reported previously as being perceptually indistinguishable but having different impacts on autonomic reflexes. As an indicator of brain activity, glucose metabolism was evaluated by PET with 2-[F]fluoro-2-deo...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32836164d4
更新日期:2013-05-29 00:00:00
abstract::This study aimed to examine the spontaneous hemodynamic fluctuations and the dysfunctional brain regions in patients with generalized anxiety disorder (GAD) using resting-state functional MRI. Previous studies have demonstrated some neural networks that are different in this patient group compared with healthy control...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000982
更新日期:2018-03-21 00:00:00
abstract::CIRCLING training (CT) decreases muscarinic acetyl-choline receptor (mAchR) binding in rat striatum. As cholinergic and dopaminergic systems interact strongly we evaluated the expression of D2-subtype dopamine receptor (DA D2) and mAchR together after CT. Animals trained from 30 to 37 days of age and sacrificed 2 mont...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199611040-00018
更新日期:1996-11-04 00:00:00
abstract::We investigated the mRNA levels of neuronal, inducible, endothelial nitric oxide synthases (nNOS, iNOS, eNOS) and tumor necrosis factor-alpha (TNF-alpha) in a rat dorsal root ganglion (DRG) after tourniquet application to a hind limb to identify molecules that trigger secondary events after peripheral nerve injury. Si...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200312020-00026
更新日期:2003-12-02 00:00:00
abstract::The dynamics of intracellular calcium concentration ([Ca2+]i) following activation of low voltage-activated (LVA) and high voltage-activated (HVA) Ca2+ currents were studied in identified relay neurons and interneurons of the rat dorsal lateral geniculate nucleus (LGNd) in situ using Ca2+ imaging and patch-clamp techn...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199707280-00001
更新日期:1997-07-28 00:00:00
abstract::We examined whether 53 adult non-aphasic patients with either left (22) or right temporal lobe lesions (31) demonstrate dissociable patterns of hemispheric asymmetries in category-specific word fluency tasks. The patients were asked to articulate as many appropriate words as possible within 60 or 90 s in response to s...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/00001756-199807130-00040
更新日期:1998-07-13 00:00:00
abstract::In situ hybridization and Northern blotting were used to study the expression of brain-derived neurotrophic factor (BDNF) mRNA in the rat brain following photochemical stroke. A focal thrombotic lesion of the sensorimotor cortex was produced by intravenously injecting the light-sensitive dye rose bengal and exposing t...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199206000-00004
更新日期:1992-06-01 00:00:00
abstract::As manifestations of prion diseases include disturbances of hypothalamic and pituitary functions, we tested the hypothesis that the cellular prion protein (PrPC) has a role as modulator of the hypothalamic-pituitary-adrenal axis. The level of corticosterone and adrenocorticotropic hormone were compared in PrPC null (P...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32830f1e90
更新日期:2008-10-08 00:00:00
abstract::Plasticity in the central nervous system may play an important role in clinical pain. The present study shows that long-term potentiation (LTP) may be induced in single wide dynamic range (WDR) neurons in the dorsal horn after high-frequency stimulation of the sciatic nerve in intact urethane anaesthetized rats. Extra...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199711100-00002
更新日期:1997-11-10 00:00:00
abstract::Cerebral blood flow (CBF) was measured at varying haematocrit values in 8 streptozotocin-diabetic and in 7 control rats using the intracarotid 133Xe technique. A hyperbolic relationship between CBF and haematocrit was established for the individual rats in both groups. Diabetic animals showed a preserved CBF response ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199211000-00010
更新日期:1992-11-01 00:00:00
abstract::Neural plasticity in the visual cortex, as tested by changes in its functional organization induced by monocular deprivation (MD), is present only during a restricted period of postnatal development (critical period). To investigate whether this process of synapse strengthening depends upon NGF, we antagonized endogen...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199410270-00013
更新日期:1994-10-27 00:00:00
abstract::Thyroid hormones, which play an important role in the development and regeneration of the nervous system, require the presence of specific nuclear T3 receptors (NT3R). In this study we provide evidence that NT3R expression by Schwann cells was up-regulated in response to a loss of axonal contact in vitro and in vivo. ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199311180-00010
更新日期:1993-11-18 00:00:00
abstract::Monoamine oxidase A (MAOA) enzymatically degrades biogenic amines such as norepinephrine, dopamine, and serotonin, and plays a key role in the regulation of their neurotransmission. Allelic variations at the MAOA locus have been implicated in the neurobiology of aggression and impulsivity. We investigated the possible...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3282f94294
更新日期:2008-03-26 00:00:00
abstract::We investigated the correlation of hippocampal volume with homocysteine, folate, vitamin B12 and B6 in alcoholic patients and healthy controls applying a Kohonen feature map (KFM) and conventional statistics. Representation of subjects on the KFM suggested an inverse correlation of hippocampal volume with blood levels...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200402090-00031
更新日期:2004-02-09 00:00:00
abstract::This study used event-related functional magnetic resonance imaging to investigate the neural basis underlying the sequential involvement of syntactic processing in the course of sentence comprehension. In experiments, a noun, case particle, and verb were presented one by one, constituting simple sentences in Japanese...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3282e9a87c
更新日期:2007-09-17 00:00:00
abstract::The rat synaptosomal membrane antigen D3, which has been studied for more than 20 years since its first demonstration as a brain-specific protein, was shown to bind monoclonal antibodies to SNAP-25, a presynaptic plasma membrane-associated protein. In addition to SNAP-25, anti-D3 antiserum also precipitated two polype...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199512000-00017
更新日期:1995-12-29 00:00:00