Co-alteration of dopamine D2 receptor and muscarinic acetylcholine receptor binding in rat striatum after circling training.

Abstract:

:CIRCLING training (CT) decreases muscarinic acetyl-choline receptor (mAchR) binding in rat striatum. As cholinergic and dopaminergic systems interact strongly we evaluated the expression of D2-subtype dopamine receptor (DA D2) and mAchR together after CT. Animals trained from 30 to 37 days of age and sacrificed 2 months later showed an enduring drop in Bmax of 40% in DA D2 and 34% in mAchR. Plotting the percentage of binding drop of both receptors for each animal showed that the reduction of one system correlates with the other (r2 = 0.71, p < 0.01; n = 8). Neither mAchR nor DA D2 were affected when training started at 20 or 60 days. We conclude that the presence of a period where CT exerts long term alterations during development involves both cholinergic and dopaminergic systems.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Ibarra GR,Paratcha GC,Wolansky MJ,Azcurra JM

doi

10.1097/00001756-199611040-00018

subject

Has Abstract

pub_date

1996-11-04 00:00:00

pages

2491-4

issue

15-17

eissn

0959-4965

issn

1473-558X

journal_volume

7

pub_type

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