Abstract:
:The restriction of herpes virus latency to mammalian sensory ganglia has led to a search for tissue-specific regulatory molecules in these neurons which alter viral gene expression. Based primarily on work in sensory-related cell lines, several prior reports have suggested that the POU-domain transcription factor Oct-2 functions in the establishment of viral latency. Here we show that among the POU-domain transcriptional regulators, Brn-3.0 is abundantly expressed in the postnatal trigeminal ganglion. In contrast, Oct-2 message and protein are not detectable by sensitive and specific assays, effectively excluding a direct role for Oct-2 in the viral life cycle in vivo.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Turner EE,Fedtsova N,Rosenfeld MGdoi
10.1097/00001756-199611250-00003subject
Has Abstractpub_date
1996-11-25 00:00:00pages
2829-32issue
18eissn
0959-4965issn
1473-558Xjournal_volume
7pub_type
杂志文章相关文献
NEUROREPORT文献大全abstract::Chromodomain on Y-like (CDYL) is a chromodomain protein that has sequence homology to members of the enoyl CoA hydratase family. Although the chromodomain of CDYL has been implicated in chromatin remodeling during mammalian spermatogenesis, the function of the Cdyl gene remains unclear. Recently, induced pluripotent s...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32835cf179
更新日期:2013-02-13 00:00:00
abstract::Plasminogen activator inhibitor-1 is a serpin that regulates the activities of plasminogen activators. However, its physiological roles in the CNS are incompletely understood. We have found that plasminogen activator inhibitor-1 has a novel biological function in the CNS: the contribution to survival of neurites on ne...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200404090-00024
更新日期:2004-04-09 00:00:00
abstract::Papaverine is a non-specific vasodilatory drug, which was found to unexpectedly cause opening of the blood-brain barrier (BBB). We studied the expression of two endothelial cell related markers, endothelial barrier antigen (EBA) as a marker of BBB intactness, and matrix metalloproteinase-9 (MMP-9), an extracellular ma...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200212030-00011
更新日期:2002-12-03 00:00:00
abstract::Diffusion tensor imaging was used to measure regional differences in brain white matter microstructure (intravoxel coherence) and macrostructure (intervoxel coherence) and age-related differences between men and women. Neuropsychiatrically healthy men and women, spanning the adult age range, showed the same pattern of...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200101220-00027
更新日期:2001-01-22 00:00:00
abstract::Densities of serotonin transporters (5-HTT) in the postmortem neocortex of behaviorally assessed Alzheimer's disease (AD) patients and aged controls were measured by radioligand binding with [3H]citalopram. It was found that 5-HTT sites in the temporal cortex of AD patients with prominent antemortem anxiety were unalt...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000077546.91466.a8
更新日期:2003-07-18 00:00:00
abstract::We investigated the mRNA levels of neuronal, inducible, endothelial nitric oxide synthases (nNOS, iNOS, eNOS) and tumor necrosis factor-alpha (TNF-alpha) in a rat dorsal root ganglion (DRG) after tourniquet application to a hind limb to identify molecules that trigger secondary events after peripheral nerve injury. Si...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200312020-00026
更新日期:2003-12-02 00:00:00
abstract::In primary cultures from rat cerebral cortex, pituitary adenylate cyclase-activating polypeptide (PACAP-38) exerted a protective effect on cell death induced by the excitotoxin NMDA in neuron-enriched cultures and also on apoptotic cell death induced by serum deprivation in mixed neuronal-glial cultures. The neuroprot...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200104170-00011
更新日期:2001-04-17 00:00:00
abstract::We evaluated the incentive motivational properties of MK-801 by determining its priming effect on drug-seeking behaviour following extinction of cocaine self-administration, an animal model for drug craving. Rats were allowed to self-administrate cocaine (0.5 mg/kg) or saline during 10 daily sessions. MK-801 (0.1-0.25...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199803090-00014
更新日期:1998-03-09 00:00:00
abstract::To investigate the effect of the N-terminal Slit2 protein on neuronal survival and development, recombinant human N-terminal Slit2 (N-Slit2) was assayed against isolated embryonic chick dorsal root ganglion sensory, ciliary ganglion and paravertebral sympathetic neurons. N-Slit2 promoted significant levels of neuronal...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200212030-00041
更新日期:2002-12-03 00:00:00
abstract::Immunohistochemical techniques were employed to examine the distribution of RNA-binding proteins A2 and B1 in the rat forebrain. Intense A2 and B1 immunolabeling were observed in the nucleoplasm of the neurons in the cerebral cortices, hippocampal formation, olfactory regions, caudate-putamen as well as the supraoptic...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200009280-00012
更新日期:2000-09-28 00:00:00
abstract::Oscillatory activity is a ubiquitous property of brain signals, and yet relatively few studies have investigated how the phase of such ongoing oscillations affects our cognition. One of the main findings in this field is that the phase of electroencephalography (EEG) in the alpha band can affect perception of millisec...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001215
更新日期:2019-04-10 00:00:00
abstract::We examined the cortical areas showing increased activation related to axis orientation discrimination in hand movement and perception by positron emission tomography (PET) in right-handed normal human subjects while they performed a hand orientation (HO) task and an orientation discrimination (OD) task. In the OD tas...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/00001756-199801260-00020
更新日期:1998-01-26 00:00:00
abstract::In the present study, the activity changes of chicken retinal ganglion cells in response to light stimuli with defined contrast were investigated, in the presence of various levels of sustained background illumination. Following a step increase of light illumination, the firing rate of most retinal ganglion cells incr...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200503150-00013
更新日期:2005-03-15 00:00:00
abstract::Formalin fixation reduces beta-amyloid precursor protein (beta APP) immunoreactivity which restricts its study in archival tissue. Formic acid pretreatment has previously been used in an attempt to overcome this problem, but makes the sections very friable. In the present study, a microwave antigen retrieval method ha...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199405000-00016
更新日期:1994-05-09 00:00:00
abstract::The inward rectifier Kir4.1, composed of KCNJ10 K channel subunits, plays an essential role in inner ear K homeostasis. We have investigated the developmental expression and localization of KCNJ10 (Kir4.1) in the guinea pig inner ear using semi-quantitative reverse transcription polymerase chain reaction and immunohis...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000208999.25234.91
更新日期:2006-04-03 00:00:00
abstract::The H-Tx rat is a polygenic inherited model of hydrocephalus. In order to identify disease-specific biomarkers associated with congenital hydrocephalus, comparative proteomic analysis was used to screen cerebellum proteins in H-Tx rats at 1 day after birth. Seven proteins showed significant changes in hydrocephalic H-...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200504250-00011
更新日期:2005-04-25 00:00:00
abstract::Effects of glutamate on synaptic transmission in the submucosal plexus of guinea-pig small intestine were studied with intracellular electrophysiological recording methods. Glutamate suppressed stimulus-evoked slow excitatory postsynaptic potentials (EPSPs) and increased the amplitude of slow inhibitory postsynaptic p...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199909290-00031
更新日期:1999-09-29 00:00:00
abstract::We used positron emission tomography to investigate whether tactile motion discrimination activates the dorsal visual stream in congenitally blind (CB) participants compared with sighted controls. The tactile stimuli consisted of either static dots, dots moving coherently in one of two possible directions, or in rando...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3283279909
更新日期:2009-04-22 00:00:00
abstract::Slices of rat cingulate cortex, when incubated in magnesium-free medium, produce spontaneous epileptiform spikes. Here it is demonstrated that the metabotropic glutamate receptor (mGluR) agonists +/- trans-1-amino-cyclopentane-1,3-dicarboxylic acid (+/- Trans-ACPD), IS3R-ACPD and quisqualic acid (quis) can reduce the ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199210000-00024
更新日期:1992-10-01 00:00:00
abstract::It has been reported that neurons in the amygdala respond to visual cues that predict reward and aversive outcomes. However, it remains unclear whether the representation of reinforcement in the amygdala depends on the relative preference for an outcome compared with another simultaneously available outcome. In this s...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3283294a2f
更新日期:2009-04-22 00:00:00
abstract::4-Aminobenzovesamicol was used to test whether activation of protein kinase C protects the vesicular acetylcholine transporter from interaction with vesamicol-like drugs. The essentially irreversible vesamicol analog inhibits the release of newly synthesized [3H]acetylcholine from stimulated hippocampal slices. Prior ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199909090-00016
更新日期:1999-09-09 00:00:00
abstract::It is not clear whether attention is necessary or not for consciousness. We studied the relationship between attention and consciousness by tracking their electrophysiological correlates. The participants attended to visual targets, ignored nontargets in the prespecified visual field and ignored all stimuli in the opp...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3280c143c8
更新日期:2007-05-28 00:00:00
abstract::Involuntary eye movements to foveal stimulation were measured in a monkey while it performed a fixation task. Second-order plaid motion generated higher velocities of eye movements than did first-order gratings, yet the latency of the early following response was no different for grating or plaid motion. Nevertheless,...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199902050-00032
更新日期:1999-02-05 00:00:00
abstract::We present the first assessment of motion vision in childhood autism. Postural reactivity to visually perceived motion was measured in five autistic children and 12 normal controls of the same chronological age. Anteroposterior as well as total body sway occurring on a force platform in response to movements in the vi...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199505300-00034
更新日期:1995-05-30 00:00:00
abstract::In this study, we have identified novel splice variants of the Na+ channel alpha subunit mRNA from cultured rat astrocytes and neuroblastoma cells. These splice variants are characterized by premature truncation or deletion of a segment in the third domain of the Na+ channel alpha subunit. The expression of three spli...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199805110-00002
更新日期:1998-05-11 00:00:00
abstract::Increased expression and nuclear accumulation of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) are early, critical events in several forms of apoptosis. In order to investigate the subcellular trafficking of GAPDH in vivo, the localization of a GAPDH-green fluorescent protein (GFP) fusion was studied in PC12, HEK 2...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199904060-00045
更新日期:1999-04-06 00:00:00
abstract::Using in situ hybridization histochemistry and immunocytochemistry the induction of immediate early genes (IEGs) was studied in the rat superior cervical ganglion (SCG) after deafferentation, axotomy and sialectomy (removal of the submandibular gland). Control SCGs showed very low levels of IEGs, whereby Fos proteins ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199301000-00009
更新日期:1993-01-01 00:00:00
abstract::Adeno-associated virus type2 (AAV-2) binds to heparan-sulfate proteoglycans on the cell surface. In vivo, attachment of viral particles to cells adjacent to the injection tract limits the distribution of AAV-2 when infused into the CNS parenchyma and heparin co-infusion might decrease the binding of AAV-2 particles to...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200107030-00037
更新日期:2001-07-03 00:00:00
abstract::Cyclooxygenase (COX)-2 is constitutively expressed in the superficial dorsal horn of the spinal cord, but its role in the spinal cord is still unclear. We examined the effect of intrathecally administered NS398, a selective COX-2 inhibitor and indomethacin, an non-selective COX-1 and COX-2 inhibitor, on the developmen...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199812010-00019
更新日期:1998-12-01 00:00:00
abstract::The neuroprotective effect of docosahexaenoic acid (DHA) on the glutamate-induced cytotoxicity in rat hippocampal cultures was investigated in the present study. DHA at 5-50 microg/ml successfully protected neurons against the cytotoxicity, markedly increased the cell viability, inhibited both nitric oxide (NO) produc...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200312190-00033
更新日期:2003-12-19 00:00:00