Generation and neuronal differentiation of induced pluripotent stem cells in Cdyl-/- mice.

abstract：:NMDA receptors (NR) are important in many neurological processes. Using a large series of human brain tissue, we show that the distribution of NR2A/B immunoreactivity varies according to position along a gyrus. For pyramidal neurons in laminae II and III, immunoreactivity is most marked at gyral crown and gyral lips, ...

journal_title：Neuroreport

authors： Sisodiya SM,Heffernan J,Harrison PJ,Squier MV,Thom M

更新日期：2000-08-03 00:00:00

abstract：:In neonatal retinal explants cultured long-term green cones are missing. Recently it was reported that thyroid hormone beta2 receptors (TR-beta2) are essential for these green cones to differentiate. Therefore transcript level of these receptors was investigated in our mouse retinal explants. However, thyroid receptor...

journal_title：Neuroreport

authors： Azadi S,Zhang Y,Caffé AR,Holmqvist B,van Veen T

更新日期：2002-05-07 00:00:00

abstract：:This study was designed to clarify the neuroprotective effects of tanshinone IIA (TSA) following cerebral ischemic insult. Adult Sprague-Dawley rats were operated upon to achieve a middle cerebral artery occlusion to cause transient focal cerebral ischemia, which were then randomly divided into the sham-operated contr...

journal_title：Neuroreport

authors： Wen PY,Li J,Lu BL,Liu J,Yang FZ,Zhou L,Luo H,Li WW,Zhou J

更新日期：2016-04-13 00:00:00

abstract：:The objective of this study was to investigate the effects of long-term mental abacus calculation training (MACT) on children's spatial attention orientation. Fifteen children with intensive MACT (MACT group) and 15 children without MACT (non-MACT group) were selected. The two groups of children were matched in age, s...

journal_title：Neuroreport

authors： Liu X,Sun Y

更新日期：2017-01-01 00:00:00

abstract：:Emerging evidence has suggested that alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) protects neurons from glutamate-induced neurotoxicity. In this study, we examined the effect of AMPA on the cell surface expression of the N-methyl-D-aspartate (NMDA) receptor, a central player in glutamate-induced neurot...

journal_title：Neuroreport

authors： Nishimoto T,Kihara T,Akaike A,Niidome T,Sugimoto H

更新日期：2009-01-28 00:00:00

abstract：:Approximately 30% of patients with fatal head injuries have deposits of amyloid beta-protein (A beta); these are predominantly individuals carrying the epsilon 4 allele of apolipoprotein E (apoE). A beta deposition occurs in Alzheimer's disease (AD), for which approximately 50% of the genetic risk is attributed to apo...

journal_title：Neuroreport

authors： Zunarelli E,Nicoll JA,Graham DI

更新日期：1996-12-20 00:00:00

abstract：:Network tools have been extensively applied to study the properties of brain functional and anatomical networks. In this paper, resiliency of Caenorhabditis elegans cortical networks against cascaded failures is studied. To this end, directed network formed by chemical connections and undirected network formed by elec...

journal_title：Neuroreport

authors： Jalili M

更新日期：2015-08-19 00:00:00

abstract：:Whole-cell recordings in voltage-clamp mode were performed on acutely isolated neurones from rat neocortex and neostriatum to examine the effects of the anticonvulsant phenytoin on a non-inactivating (persistent) Na+ current (INaP). INaP was chosen because it enhances neuronal excitability near firing threshold, which...

journal_title：Neuroreport

authors： Chao TI,Alzheimer C

更新日期：1995-09-11 00:00:00

abstract：:We examined differences in brain activity in response to two types of mechanical stimulation, which have been reported previously as being perceptually indistinguishable but having different impacts on autonomic reflexes. As an indicator of brain activity, glucose metabolism was evaluated by PET with 2-[F]fluoro-2-deo...

journal_title：Neuroreport

authors： Watanabe N,Ishii K,Hotta H,Oda K,Sakata M,Toyohara J,Ishiwata K

更新日期：2013-05-29 00:00:00

abstract：OBJECTIVE:The current study aims to investigate whether computer generated (CG) expressions of emotion evoke similar emotional appraisal processing in the lateral orbitofrontal cortex (lOFC) compared to real human expressions, as well as how speech cues would influence the processing. METHODS:Functional near-infrared ...

journal_title：Neuroreport

authors： Zhao T,Chen J,Wang L,Yan N

更新日期：2020-04-08 00:00:00

abstract：:Adenosine has an anticonvulsant effect in various models of epilepsy. This effect appears to be mediated through the activation of adenosine A1 receptors (A1Rs). We immunohistochemically investigated the changes of A1Rs expression in kainate-treated and hippocampus-kindled rats as chronic models of epilepsy. In the no...

journal_title：Neuroreport

authors： Ochiishi T,Takita M,Ikemoto M,Nakata H,Suzuki SS

更新日期：1999-11-26 00:00:00

abstract：:ONO-1714, a selective inhibitor of inducible nitric oxide synthetase (iNOS) attenuated the increase of apoptosis and improved the functional outcome of urinary bladder after traumatic spinal cord injury. These findings suggest that iNOS plays a role in the process of SCI. Early treatment with 30 mg/kg methylprednisolo...

journal_title：Neuroreport

authors： Yu Y,Matsuyama Y,Nakashima S,Yanase M,Kiuchi K,Ishiguro N

更新日期：2004-09-15 00:00:00

abstract：:We examined the induction of progesterone receptor-immunoreactive (PR-ir) cells by estrogen in the rat preoptic area and ventromedial hypothalamic nucleus. Ovariectomized young (3-month-old) and old (24-month-old) female rats were treated with estrogen or cholesterol for 4 days. Estrogen significantly increased PR-ir ...

journal_title：Neuroreport

authors： Furuta M,Fukushima A,Chiba S,Sano A,Akema T,Kimura F,Funabashi T

更新日期：2010-08-04 00:00:00

abstract：:We studied whether pro-survival Akt was activated after transient focal cerebral ischemia and whether it inhibited pro-apoptotic Bad. Phosphorylation of Akt (serine-473) was enhanced in cortex after 1-hour ischemia, and also after 1h and 6 h of reperfusion, but it returned back to that in controls by 24 h. After this ...

journal_title：Neuroreport

authors： Friguls B,Justicia C,Pallàs M,Planas AM

更新日期：2001-10-29 00:00:00

abstract：:Timing of the mammalian circadian clock of the suprachiasmatic nucleus (SCN) is regulated by photic input from the retina. Retinorecipient units entrain rhythmicity of SCN pacemaker cells in part through their release of vasoactive intestinal polypeptide (VIP). The underlying nature of this process is conjectural, how...

journal_title：Neuroreport

authors： Francl JM,Kaur G,Glass JD

更新日期：2010-11-17 00:00:00

abstract：:Postulating that central IL-1 is involved in the pathogenesis of cancer anorexia we measured IL-1 alpha in cerebrospinal fluid (CSF) from anorectic tumor bearing (TB) rats and non-tumor bearing controls, and correlated their CSF IL-1 alpha with food intake and tumor weight. Food intake in controls was significantly hi...

journal_title：Neuroreport

authors： Opara EI,Laviano A,Meguid MM,Yang ZJ

更新日期：1995-03-27 00:00:00

abstract：:The present study investigated the effect of lexical competition on the time course of spoken word recognition in Mandarin Chinese using a unimodal auditory priming paradigm. Two kinds of competitive environments were designed. In one session (session 1), only the unrelated and the identical primes were presented befo...

journal_title：Neuroreport

authors： Huang X,Yang JC

更新日期：2016-01-20 00:00:00

abstract：:With the purpose of elucidating the functional fields involved in the discrimination of visual form based either on luminance or binocular disparity cues, we used PET to measure changes in regional cerebral blood flow (rCBF) in ten volunteers while they performed visual discrimination tasks. The averaged standardized ...

journal_title：Neuroreport

authors： Gulyás B,Roland PE,Heywood CA,Popplewell DA,Cowey A

更新日期：1994-11-21 00:00:00

abstract：:Thyroid hormones, which play an important role in the development and regeneration of the nervous system, require the presence of specific nuclear T3 receptors (NT3R). In this study we provide evidence that NT3R expression by Schwann cells was up-regulated in response to a loss of axonal contact in vitro and in vivo. ...

journal_title：Neuroreport

authors： Walter IB

更新日期：1993-11-18 00:00:00

abstract：:Older adults are known to gain more than younger adults from the simultaneous presentation of semantically congruent sensory stimuli. Although these findings are quite exciting, they may not solely be due to age-related differences in multisensory processing. Rather, enhanced integration may be explained by alteration...

journal_title：Neuroreport

authors： Peiffer AM,Mozolic JL,Hugenschmidt CE,Laurienti PJ

更新日期：2007-07-02 00:00:00

abstract：:The temperature of the tail skin is an important factor determining tail-flick latency to noxious radiant heat in rats and mice. The temperature of the skin may also be important in determining the behavioural response in the formalin test. Morphine in low and moderate doses strongly affected the core and tail skin te...

journal_title：Neuroreport

authors： Tjølsen A,Hole K

更新日期：1992-06-01 00:00:00

abstract：:Subcortical lesions have been simultaneously implicated in both real and simulated movement deficits. However, the analysis of the simulated opposition axis in precision grasping reveals that, in individuals with idiopathic bilateral Parkinson' disease motor imagery is impaired and that execution of overt movements is...

journal_title：Neuroreport

authors： Frak V,Cohen H,Pourcher E

更新日期：2004-06-28 00:00:00

abstract：:Increased oxidative stress in the brain due to chronic ethanol consumption is known to result in a number of neurodegenerative changes. This study was designed to test whether dietary supplementation of grape polyphenols (GP) can offer protection to the neurodegenerative changes resulting from chronic ethanol consumpt...

journal_title：Neuroreport

authors： Sun GY,Xia J,Draczynska-Lusiak B,Simonyi A,Sun AY

更新日期：1999-01-18 00:00:00

abstract：:Intrinsic circuitry in the barrel cortex has been shown to be readily modifiable in response to changes in the patterns of sensory input, even in adult animals. It is believed that sensory experience modifies synaptic circuits by imposing specific patterns of repetitive presynaptic and postsynaptic coactivity, i.e. by...

journal_title：Neuroreport

authors： Aroniadou-Anderjaska V,Keller A

更新日期：1995-11-27 00:00:00

abstract：:The glomerular layer of the olfactory bulb contains a substantial population of dopaminergic neurons. We determined the quantity and location of D1 and D2 dopamine receptors which are the presumed targets of these neurons. Binding of the D1 selective ligand [3H]SCH23390 was slightly above background and was distribute...

journal_title：Neuroreport

authors： Nickell WT,Norman AB,Wyatt LM,Shipley MT

更新日期：1991-01-01 00:00:00

abstract：:A novel allograft paradigm was used to test whether adult mammalian central axons regenerate within a peripheral nerve environment containing intact sensory axons. Retinal ganglion cell axon regeneration was compared following anastomosis of dorsal root ganglia grafts or conventional peripheral nerve grafts to the adu...

journal_title：Neuroreport

authors： King C,Bartlett C,Sauvé Y,Lund R,Dunlop S,Beazley L

更新日期：2006-02-06 00:00:00

abstract：:A double-stranded DNA end-binding factor with high levels of expression in brain and testis of adult mice was identified as the Ku protein, earlier described as an autoantigen in connective tissue diseases and found to be essential for recombination of the immunoglobulin genes and DNA repair. High Ku levels were found...

journal_title：Neuroreport

authors： Bakalkin G,Yakovleva T,Hurd YL,Nussenzweig A,Li GC,Terenius L

更新日期：1998-06-22 00:00:00

abstract：:Levels of mRNAs encoding for the two isoforms of glutamate decarboxylase, GAD67 and GAD65, were quantified in the rat striatum and cerebral cortex following single injections of the non-competitive NMDA receptor antagonist MK-801. Acute MK-801 induced a dose-dependent decrease in GAD65 mRNA levels in ventral sectors o...

journal_title：Neuroreport

authors： Laprade N,Soghomonian JJ

更新日期：1995-10-02 00:00:00

abstract：:The distribution of GABA(B) receptor subunits GABA(B(1a)), GABA(B(1b)) and GABA(B2), has been examined in the cerebral cortex and thalamus of adult rats using an immunocytochemical technique. GABA(B(1a)) and GABA(B(1b)) subunits co-localized with GABA(B2) in the cortex, where afferent thalamic GABAergic axons project ...

journal_title：Neuroreport

authors： Princivalle AP,Pangalos MN,Bowery NG,Spreafico R

更新日期：2001-03-05 00:00:00

abstract：:Amyloid precursor protein binding protein-1 (APP-BP1) was first identified as an interacting protein of APP. In this study, we explored whether APP-BP1 plays a role in neuronal differentiation of fetal neural stem cells. APP-BP1 knockdown by small interfering RNA treatment was found to downregulate neuronal differenti...

journal_title：Neuroreport

authors： Hong BH,Ha S,Joo Y,Kim JA,Chang KA,Woo RS,Suh YH,Kim JH,Kim HS

更新日期：2012-01-25 00:00:00