Abstract:
:Postulating that central IL-1 is involved in the pathogenesis of cancer anorexia we measured IL-1 alpha in cerebrospinal fluid (CSF) from anorectic tumor bearing (TB) rats and non-tumor bearing controls, and correlated their CSF IL-1 alpha with food intake and tumor weight. Food intake in controls was significantly higher than that in anorectic TB rats. Eight of the 13 anorectic TB rats had detectable CSF IL-1 alpha; no CSF IL-1 alpha was detected in controls. In anorectic TB rats a negative correlation existed between CSF IL-1 alpha and food intake and a positive correlation between CSF IL-1 alpha and tumor weight. Data suggest a link between CSF IL-1 alpha and the pathogenesis of cancer anorexia.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Opara EI,Laviano A,Meguid MM,Yang ZJdoi
10.1097/00001756-199503270-00011subject
Has Abstractpub_date
1995-03-27 00:00:00pages
750-2issue
5eissn
0959-4965issn
1473-558Xjournal_volume
6pub_type
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