Correlation between food intake and CSF IL-1 alpha in anorectic tumor bearing rats.

Abstract:

:Postulating that central IL-1 is involved in the pathogenesis of cancer anorexia we measured IL-1 alpha in cerebrospinal fluid (CSF) from anorectic tumor bearing (TB) rats and non-tumor bearing controls, and correlated their CSF IL-1 alpha with food intake and tumor weight. Food intake in controls was significantly higher than that in anorectic TB rats. Eight of the 13 anorectic TB rats had detectable CSF IL-1 alpha; no CSF IL-1 alpha was detected in controls. In anorectic TB rats a negative correlation existed between CSF IL-1 alpha and food intake and a positive correlation between CSF IL-1 alpha and tumor weight. Data suggest a link between CSF IL-1 alpha and the pathogenesis of cancer anorexia.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Opara EI,Laviano A,Meguid MM,Yang ZJ

doi

10.1097/00001756-199503270-00011

subject

Has Abstract

pub_date

1995-03-27 00:00:00

pages

750-2

issue

5

eissn

0959-4965

issn

1473-558X

journal_volume

6

pub_type

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