Inhibition of DNA synthesis in human gliomas by roscovitine.

abstract：:To analyze an auditory scene, the segregation of the input into separate streams of information is necessary. Here, the mismatch negativity (MMN) of the event-related potential was used to trace the number of simultaneously monitored streams in auditory scene analysis. Subjects passively listened to sounds belonging t...

journal_title：Neuroreport

authors： Nager W,Teder-Sälejärvi W,Kunze S,Münte TF

更新日期：2003-05-06 00:00:00

abstract：:Homotopic and isochronic transplantation of the alar plate of the rhombomeres 7 and 8 was performed between chick and quail embryos at the stage of 10-14 somites. Analysis of the graft derivatives in 12-day-old chimeric embryos by means of the quail nucleolar marker showed that the ipsilateral inferior olive is formed...

journal_title：Neuroreport

authors： Ambrosiani J,Armengol JA,Martinez S,Puelles L

更新日期：1996-05-17 00:00:00

abstract：:Optic nerves of adult rats were crushed 2 mm behind the eye to examine the ability of retinal ganglion cells (RGCs) to regenerate their axons. Some animals were treated with the immunophilin ligands FK 506 or GPI 1046 for up to 4 weeks. After 10 days to 16 months, regenerating RGC axons were visualized using anterogra...

journal_title：Neuroreport

authors： Campbell G,Holt JK,Shotton HR,Anderson PN,Bavetta S,Lieberman AR

更新日期：1999-12-16 00:00:00

abstract：:To compare the diagnostic value of T1-inversion recovery sequence (T1 IR) to that of a T2-sequence with contrast inversion (T2 CI) in the investigation of heterotopias. In this study, we processed a contrast-inverted copy of our coronal T2-sequence of 21 patients with subependymal and subcortical heterotopias on an on...

journal_title：Neuroreport

authors： Rösch J,Mennecke A,Knott M,Hamer HM,Doerfler A,Engelhorn T

更新日期：2020-06-07 00:00:00

abstract：:beta-N-methylamino-L-alanine (L-BMAA) is an excitotoxin whose neurodegenerative effects are associated with its agonist properties at the N-methyl-D-aspartate (NMDA) receptor. We measured the effects of L-BMAA on inositol phosphate (InsP) formation in primary cultured striatal neurons. This culture is almost devoid of...

journal_title：Neuroreport

authors： Manzoni OJ,Prezeau L,Bockaert J

更新日期：1991-10-01 00:00:00

abstract：:The discovery of mis-sense mutations linking the presenilin-1 (PS-1) gene on chromosome 14 to Alzheimer's disease (AD) has lead to a thorough investigation of this locus. The PS-1 gene contains a polymorphism creating two alleles. The most common allele, allele 1, has been linked with late-onset AD. Given the clinical...

journal_title：Neuroreport

authors： Singleton AB,Lamb H,Leake A,McKeith IG,Ince PG,Perry RH,Morris CM

更新日期：1997-11-10 00:00:00

abstract：:The functional integrity of the 'on' and 'off' neurovisual pathways has been examined in the central visual fields of normal (n = 13), glaucomatous (n = 21) and ocular hypertensive (n = 21) individuals. The detection thresholds to light increments (onsets = bright spots) and light decrements (offsets = dark spots) on ...

journal_title：Neuroreport

authors： Mutlukan E

更新日期：1993-09-03 00:00:00

abstract：:Predicting neuron death or survival after axonal injury is important in neurotrauma research. We now used in vivo confocal neuroimaging microscopy to repeatedly visualize retinal ganglion cells after optic nerve crush and studied their morphological alterations and ultimate fate. An intracollicular injection of a retr...

journal_title：Neuroreport

authors： Rousseau V,Engelmann R,Sabel BA

更新日期：1999-11-08 00:00:00

abstract：:We investigated some in vitro pharmacological properties of a novel human dopamine D2-like receptor antagonist, YM-50001 [(R)-5-chloro-4-cyclopropylacarbonylamino-2-methoxy-N-[1-(3-methox ybenzyl)- 3-pyrrolidinyl]benzamide monooxalate]. Receptor binding studies revealed that YM-50001 had a potent affinity for human D4...

journal_title：Neuroreport

authors： Hidaka K,Tada S,Matsumoto M,Ohmori J,Maeno K,Yamaguchi T

更新日期：1996-11-04 00:00:00

abstract：:The serotonin transporter (SERT) terminates serotonergic neurotransmission by rapid reuptake of 5-hydroxytryptamine (5-HT) into the nerve terminal or axonal varicosities. SERT represents the target of various antidepressants which inhibit 5-HT transport and are widely used for the pharmacotherapy of depression. Here, ...

journal_title：Neuroreport

authors： Horschitz S,Hummerich R,Schloss P

更新日期：2001-07-20 00:00:00

abstract：:In the present study, we tested the hypothesis that interleukin (IL)-10 down-regulates human microglial cell IL-8 release by inhibiting activation of nuclear factor kappa B (NF-kappaB). Immunohistochemical staining demonstrated that IL-10 markedly suppressed lipopolysaccharide (LPS)- and IL-1beta-stimulated IL-8 expre...

journal_title：Neuroreport

authors： Ehrlich LC,Hu S,Peterson PK,Chao CC

更新日期：1998-06-01 00:00:00

abstract：:In line with a possible role of vergence in orienting visual attention, we sought to study this eye movement in young children to provide insights on face perception. For this purpose, we measured the modulation in the angle of eye vergence in a sample of 39 children aged 6-36 months and compared it when presenting st...

journal_title：Neuroreport

authors： Esposito FL,Supèr H

更新日期：2018-02-07 00:00:00

abstract：:Hypoxia-inducible factor-1 (HIF-1) regulates the expression of neuroprotective genes such as erythropoietin (EPO). We investigated the mechanism by which zinc, an excitotoxin-like metal, regulates HIF-1 under hypoxic conditions in astrocytes. In hypoxic LN215 cells, HIF-1alpha stabilized and accumulated in the nucleus...

journal_title：Neuroreport

authors： Kim I,Kim CH,Seo GH,Kim HS,Lee J,Kim DG,Ahn YS

更新日期：2008-07-02 00:00:00

abstract：:Network tools have been extensively applied to study the properties of brain functional and anatomical networks. In this paper, resiliency of Caenorhabditis elegans cortical networks against cascaded failures is studied. To this end, directed network formed by chemical connections and undirected network formed by elec...

journal_title：Neuroreport

authors： Jalili M

更新日期：2015-08-19 00:00:00

abstract：:Latest reports suggest the involvement of insulin in modulating memory. A few published in-vitro studies favor the antidementia effect of insulin. Thus, the present study aimed to evaluate the prophylactic role of insulin and its combination with glucose and its possible mechanism(s) in an aluminum chloride (AlCl3)-in...

journal_title：Neuroreport

authors： Nampoothiri M,Kumar N,Venkata Ramalingayya G,Gopalan Kutty N,Krishnadas N,Mallikarjuna Rao C

更新日期：2017-06-14 00:00:00

abstract：:The conditioned place preference (CPP) induced by cocaine 2.5 mg/kg was measured in rats pre-exposed to ethanol (14 days with only 10% v/v ethanol followed by a free choice between ethanol solution and water for 14 days). Rats were divided according to their alcohol intake during the free choice period into low-drinki...

journal_title：Neuroreport

authors： Le Pen G,Duterte-Boucher D,Daoust M,Costentin J

更新日期：1998-08-24 00:00:00

abstract：:Neural imaging studies have shown that the brains of skilled musicians respond differently to musical stimuli than do the brains of non-musicians, particularly for musicians who commenced practice at an early age. Whether brain attributes related to musical skill are attributable to musical practice or are hereditary ...

journal_title：Neuroreport

authors： Pantev C,Roberts LE,Schulz M,Engelien A,Ross B

更新日期：2001-01-22 00:00:00

abstract：:We earlier showed that leucine-rich glioma inactivated 3 (LGI3) colocalizes with amyloid beta peptide (Abeta) taken up by astrocytes both in vitro and in vivo, and that LGI3 accumulated with endocytosis-associated proteins in aged monkey brains. In this study, we confirmed that LGI3 localizes to the endocytic pathway ...

journal_title：Neuroreport

authors： Okabayashi S,Kimura N

更新日期：2008-08-06 00:00:00

abstract：:Parturition plays a critical role in the full expression of maternal behavior in postpartum females, yet the precise mechanism remains unclear. Here we examined the role of parturition in the activation of Fos and FosB in the central oxytocin receptor (OTR) system in rats. Although expression of FosB, not Fos, was see...

journal_title：Neuroreport

authors： Lin SH,Kiyohara T,Sun B

更新日期：2003-08-06 00:00:00

abstract：:Hyperactivity of the hypothalamic-pituitary-adrenal axis and impairment of the central corticotropin-releasing factor system are factors in the pathogenesis of depression. Though several antagonists of the corticotropin-releasing factor 1 receptor were effective in the recognized behavioral tests for antidepressant ac...

journal_title：Neuroreport

authors： Wang XB,Zhang YQ,Xue RR,Yang ZZ,Zhang XF

更新日期：2020-01-08 00:00:00

abstract：OBJECTIVES:There are subclinical neurologic deficits in cirrhotic patients without overt hepatic encephalopathy. We aimed to use F-fluorodeoxyglucose PET/computed tomography to explore the impaired brain glucose metabolism of subclinical hepatic encephalopathy in cirrhosis. METHODS:Thirty-seven patients with hepatitis...

journal_title：Neuroreport

authors： Zhang W,Ning N,Li X,Li M,Duan X,Guo Y,Dang Y,Li Y,Gao J,Ye J,Yang J

更新日期：2019-08-07 00:00:00

abstract：:To compare the effectiveness of cyclosporin-A (CsA) with methylprednisolone (MP) or a combination of both upon inhibition of lipid peroxidation (LP) after spinal cord (SC) injury, rats were treated with either CsA, MP, CSA+MP or vehicle starting 1 h after SC contusion at T9 level. LP was assessed 24h after injury by t...

journal_title：Neuroreport

authors： Diaz-Ruiz A,Rios C,Duarte I,Correa D,Guizar-Sahagun G,Grijalva I,Madrazo I,Ibarra A

更新日期：2000-06-05 00:00:00

abstract：:Recently, we have generated transgenic mice (designated as SJLB) carrying human N279K mutant tau, one of the tau mutations causing parkinsonism linked to chromosome 17 (FTDP-17). SJLB mice mimic some features of behavioral alterations and neuronal pathology of patients with Alzheimer's disease. To investigate how tau ...

journal_title：Neuroreport

authors： Takano M,Otani M,Sakai A,Kadoyama K,Matsuyama S,Matsumoto A,Takenokuchi M,Sumida M,Taniguchi T

更新日期：2009-12-09 00:00:00

abstract：:Presenilin-1 (PS-1) and amyloid precursor protein (APP) have been linked to the pathogenesis of Alzheimer's disease. While APP accumulation is well documented in several models of brain injury, the role of PS-1 levels in neurodegeneration, if any, remains to be elucidated. The current studies examined PS-1 and APP exp...

journal_title：Neuroreport

authors： Calingasan NY,Gandy SE,Gibson GE

更新日期：1997-07-28 00:00:00

abstract：:Psychotic-like episodes in divers exposed to high pressure have been attributed to either the high-pressure neurological syndrome, confinement in pressure chamber, the subject's personality, or the addition of nitrogen or hydrogen to the basic helium-oxygen breathing mixture used for deep diving. Alternatively, it is ...

journal_title：Neuroreport

authors： Abraini JH

更新日期：1995-03-07 00:00:00

abstract：:Successful practice of clinical deep brain stimulation (DBS) calls for basic research on the mechanisms and explorations of new indications in animals. In the article, a new implantable, single-channel, low-power miniature device is proposed, which may transmit pulses chronically into the brain nucleus of freely movin...

journal_title：Neuroreport

authors： Liu H,Wang C,Zhang F,Jia H

更新日期：2017-02-08 00:00:00

abstract：:The aim of this study was to investigate distinct neurometabolites in the right and left thalamus and insula of patients with complex regional pain syndrome (CRPS) compared with healthy controls using proton magnetic resonance spectroscopy. Levels of N-acetylaspartate (NAA), N-acetylaspartylglutamate (NAAG), myo-inosi...

journal_title：Neuroreport

authors： Jung YH,Kim H,Jeon SY,Kwon JM,Kim YC,Lee WJ,Lee D,Lee JY,Moon JY,Kang DH

更新日期：2019-01-16 00:00:00

abstract：:The brain constructs multiple representations of near and far space but it is unclear which spatial mechanism guides reaching across eye movements in near space. Retinocentric reaching representations are known to exist in parietal cortex, but must be updated during eye movements, in order to remain accurate. In contr...

journal_title：Neuroreport

authors： Medendorp WP,Crawford JD

更新日期：2002-04-16 00:00:00

abstract：:Texas Red-labelled dextran with a mol. wt of 3000 g mol-1, a marker for the extracellular space, was injected unilaterally into the neostriatum of adult rats (0.3-30 micrograms microliter-1) and its distribution evaluated 1 min to 5 h later. Diffusion in the neuropil was observed with clearance starting after 30 min. ...

journal_title：Neuroreport

authors： Bjelke B,England R,Nicholson C,Rice ME,Lindberg J,Zoli M,Agnati LF,Fuxe K

更新日期：1995-05-09 00:00:00

abstract：:An exaggerated startle response caused by mutations of the alpha 1 subunit gene of the inhibitory glycine receptor (GLRA1) is the key symptom of human hyperekplexia or startle disease. The recessive mouse mutant spasmodic (spd) carries a missense mutation in the corresponding murine Glra1 gene which reduces the affini...

journal_title：Neuroreport

authors： Koch M,Kling C,Becker CM

更新日期：1996-02-29 00:00:00