Abstract:
:The pattern of immunoreactivity for amyloid precursor (APP) and B-cell lymphoma protooncogene (Bcl-2) proteins in the rat retina was studied after intravitreal injection of basic fibroblast growth factor (bFGF) or transforming growth factor-beta (TGFbeta). In normal control retinas, intense immunostaining of APP and Bcl-2 was observed primarily in the endfeet and proximal part of radial processes of Müller glial cells. A dose-dependent reduction in immunostaining of APP and Bcl-2 in Müller cells was observed after injection of bFGF and TGFbeta. These results provide the first evidence that APP and Bcl-2 can be down-regulated by cytokines in vivo.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Chen ST,Jen A,Gentleman SM,Jen LSdoi
10.1097/00001756-199902250-00012subject
Has Abstractpub_date
1999-02-25 00:00:00pages
509-12issue
3eissn
0959-4965issn
1473-558Xjournal_volume
10pub_type
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