Abstract:
:The distribution of histamine H1, H3, dopamine D1 and D2 receptors in the brain was studied by receptor autoradiography using a high-sensitivity and high-resolution imaging plate system. [3H]Pyrilamine, [3H](R)alpha-methyl-histamine, [11C]SCH23390, and [11C]N-methylspiperone (or [11C]YM-09151-2) were used as ligands to identify H1, H3, D1 and D2 receptors, respectively. Two different receptors (dopamine D2 and histamine H3) could be also labelled simultaneously in a single cryostat-sliced section using [11C]N-methylspiperone and [3H](R)alpha-methylhistamine, respectively. The imaging plate system is useful for receptor autoradiography of positron emitter-labelled and tritium-labelled receptor-ligands because of its high sensitivity.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Yanai K,Ryu JH,Watanabe T,Iwata R,Ido Tdoi
10.1097/00001756-199211000-00003subject
Has Abstractpub_date
1992-11-01 00:00:00pages
961-4issue
11eissn
0959-4965issn
1473-558Xjournal_volume
3pub_type
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