Abstract:
:Both extracellular guanosine and adenosine stimulated astrocyte proliferation in vitro and increased intracellular cAMP 6-fold within 2 min. The effects of both guanosine and adenosine on proliferation and cAMP levels were inhibited by antagonists of adenosine A2 receptors but augmented by A1 receptor antagonists. The correlation between cAMP accumulation and stimulation of cell proliferation by adenosine and guanosine indicates that increased intracellular cAMP may be one of the second messengers involved in these effects. Guanosine is not an adenosine A2 receptor agonist and does not activate adenylate cyclase. It may exert its effects indirectly by increasing the endogenous extracellular adenosine concentration.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Rathbone MP,Middlemiss PJ,DeLuca B,Jovetich Mdoi
10.1097/00001756-199111000-00007subject
Has Abstractpub_date
1991-11-01 00:00:00pages
661-4issue
11eissn
0959-4965issn
1473-558Xjournal_volume
2pub_type
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