Abstract:
:Delayed neuronal death induced by transient forebrain ischemia in the rat hippocampus is preceded by a prominent microglial reaction which begins within minutes after the ischemic injury. In the present study we have examined the effect of the non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist MK-801 on microglial activation and neuronal survival. Using lectin histochemistry to detect microglia, we show that the systemic administration of MK-801 prior to ischemia prevents microglial activation, as well as delayed death of CA1 pyramidal neurons. The results demonstrate that early blockage of the glutamate cascade prevents microglial activation, and could suggest a role for microglia in mediating ischemic injury.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Streit WJ,Morioka T,Kalehua ANdoi
10.1097/00001756-199202000-00006subject
Has Abstractpub_date
1992-02-01 00:00:00pages
146-8issue
2eissn
0959-4965issn
1473-558Xjournal_volume
3pub_type
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