Antisense oligonucleotide to c-fos induces ipsilateral rotational behaviour to d-amphetamine.

Abstract:

:The immediate-early genes, especially c-fos, have been suggested to have an important role in neuronal plasticity and memory. However, it has been difficult to determine if in fact c-fos can participate in control of behaviour. Here we can report that direct unilateral infusion into the rat neostriatum of an antisense phosphothioate oligodeoxynucleotide to c-fos mRNA leads to the rapid induction of ipsilateral rotational behaviour after d-amphetamine administration. This is associated with an elimination of the in vivo expression of Fos-like immunoreactivity within the infused region of neostriatum. Following infusion of these oligodeoxynucleotides labelled with fluorescein isothiocyanate they appear with a nuclear and cytoplasmic location in a large number of nerve cells, many of which are immunoreactive for dopamine and cyclic AMP regulated phosphoprotein. The present findings suggest that the immediate-early gene c-fos has a role also in control of behavioural activity, as illustrated in D1 receptor containing striatal neurones.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Sommer W,Bjelke B,Ganten D,Fuxe K

doi

10.1097/00001756-199312000-00024

subject

Has Abstract

pub_date

1993-12-13 00:00:00

pages

277-80

issue

3

eissn

0959-4965

issn

1473-558X

journal_volume

5

pub_type

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