Abstract:
:The reduced steroids 3 alpha-hydroxy-5 alpha-pregnan-20-one (allopregnanolone) and 3 alpha,21-di-hydroxy-5 alpha-pregnan-20-one (allotetrahydroDOC) are potent ligands of GABAA receptors. This study examined the possible modulatory effect of these metabolites on GABA inhibition of somatostatin release in cultured hypothalamic neurones. Allopregnanolone potentiates GABA inhibition, and reversed picrotoxin and bicuculline-induced augmentation of somatostatin release in a dose-dependent manner. AllotetrahydroDOC also inhibits the stimulated release induced by the antagonists, but did not modify that induced by depolarizing concentrations of K+. Pregnenolone sulphate had no effect on picrotoxin-induced somatostatin release. These findings clearly establish that 3 alpha-hydroxysteroids modulate GABA inhibition of hypothalamic somatostatin release.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Tapia-Arancibia L,André M,Belmar J,Arancibia Sdoi
10.1097/00001756-199510020-00025subject
Has Abstractpub_date
1995-10-02 00:00:00pages
1927-31issue
14eissn
0959-4965issn
1473-558Xjournal_volume
6pub_type
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