Odors increase Fos in olfactory bulb neurons including dopaminergic cells.

Abstract:

:Neuronal activity may lead to long lasting changes in cell phenotype through induction of genes such as c-fos which encode transcriptional regulatory factors. Odor-activated olfactory bulb cells exhibit increases in c-fos mRNA expression. The present study examined whether odor stimulation of awake rats also leads to increases in Fos protein in these cells. The phenotype of Fos-immunoreactive cells was partially characterized using double-immunoperoxidase staining. Odor exposure increased Fos-immunoreactivity (IR) in specific sets of olfactory bulb neurons. Fos-IR was not co-localized with IR for glial fibrillary acidic protein, but was co-localized with tyrosine hydroxylase (TH)-IR in a subpopulation of dopaminergic neurons, suggesting that bulbar TH expression may be regulated in part by a Fos mechanism.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Guthrie KM,Gall CM

doi

10.1097/00001756-199511000-00012

subject

Has Abstract

pub_date

1995-11-13 00:00:00

pages

2145-9; discussion 2103

issue

16

eissn

0959-4965

issn

1473-558X

journal_volume

6

pub_type

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