Abstract:
:Vectors based on lentiviruses are opening up new approaches for the treatment of neurodegenerative diseases. Currently, the equine infectious anaemia virus (EIAV) vector is one of the most attractive gene delivery systems with respect to neuronal tropism. The aim was to validate EIAV-lentiviral vectors as a gene delivery system for neurotrophic factor genes in an animal model of Parkinson's disease. EIAV carrying the glial cell line-derived neurotrophic factor (GDNF) gene was unilaterally injected into rat striatum and above the substantia nigra (SN). One week later, the rats received a 6-OHDA lesion into the ipsilateral striatum. GDNF delivery led to extensive expression of GDNF protein within the striatum. In addition, near complete protection against dopaminergic cell death was observed in the GDNF-treated group.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Azzouz M,Ralph S,Wong LF,Day D,Askham Z,Barber RD,Mitrophanous KA,Kingsman SM,Mazarakis NDdoi
10.1097/00001756-200404290-00011subject
Has Abstractpub_date
2004-04-29 00:00:00pages
985-90issue
6eissn
0959-4965issn
1473-558Xpii
00001756-200404290-00011journal_volume
15pub_type
杂志文章相关文献
NEUROREPORT文献大全abstract::Event-related potential studies have reported error-related negativity following both error commission and feedback indicating errors or monetary loss. The present study examined whether error-related negativities could be elicited by a predictive cue presented prior to both the decision and subsequent feedback in a g...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3282f0d50b
更新日期:2007-11-19 00:00:00
abstract::We investigated the effect of an NO synthase inhibitor, NG-monomethyl-L-arginine (L-NMMA), on the levels of endogenous GABA in the rat striatum using in vivo microdialysis. Rats were perfused with the artificial CSF containing L-NMMA (0.1, 0.3 and 1.0 mM) or its inactive isomer D-NMMA (1.0 mM) for 1 h. Infusion of L-N...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199507100-00016
更新日期:1995-07-10 00:00:00
abstract::A synchronizing volley of excitation was delivered to cells from the primary visual cortex of the anaesthetized cat by an electrical pulse stimulation of the optic radiations. In intracellular records, this resulted in an initial, fast depolarization of the membrane potential followed by a longer lasting (266 ms) hype...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200004270-00020
更新日期:2000-04-27 00:00:00
abstract::Reading is a learned skill that is likely influenced by both brain maturation and experience. Functional imaging studies have identified brain regions important for skilled reading, but the structural brain changes that co-occur with reading acquisition remain largely unknown. We investigated maturational volume chang...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000121
更新日期:2014-03-26 00:00:00
abstract::As early-onset hypothyroidism produces audiogenic seizure susceptibility (AGS) in rodents, the role of TR alpha 1 and TR beta thyroid hormone receptors in AGS was investigated. AGS occurs in mice lacking specifically TR beta (Thrb(tm1/tm1)) and is marked by early onset and persistence, thereby differing from mouse str...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200108080-00015
更新日期:2001-08-08 00:00:00
abstract::The localization of PKC gamma mRNA expression during the maturation of rat cerebellum has been studied by in situ hybridization. We found a transient expression over the granule cell layer and persistent high expression in the Purkinje cells during postnatal development. Expression in granule cells appeared as early a...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199307000-00015
更新日期:1993-07-01 00:00:00
abstract::We recorded event-related potentials (ERPs) in 2-month-old infants in two different states of alertness: awake and asleep. Syllables varying in vowel duration (long vs short) were presented in an oddball paradigm, known to elicit a mismatch brain response. ERPs of both groups showed a mismatch response reflected in a ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200207190-00006
更新日期:2002-07-19 00:00:00
abstract::Magnetic brain responses were recorded to clarify the cortical representation of vowel processing in Japanese. We investigated the peak latencies and equivalent current dipoles of the auditory N1m responses to the Japanese vowels [a], [i], [o], and [u]. In intraindividual analyses for a single participant, well-replic...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000230503.47973.b7
更新日期:2006-07-31 00:00:00
abstract::Human morning/evening preferences has recently been reported to be associated with polymorphism of the 3' flanking region of the Clock gene, which was the first identified mammalian circadian clock gene. We recorded body temperature, spontaneous activity, electroencephalogram and electromyogram for 48 h in mice with J...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200105250-00033
更新日期:2001-05-25 00:00:00
abstract::With the purpose of mapping representations of the finger and proximal arm in the human primary motor cortex (MI), we measured regional cerebral blood flow (rCBF) in eight right-handed normal volunteers during self-paced finger and proximal arm movements. Each movement activated two different fields in MI, one located...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199501000-00003
更新日期:1995-01-26 00:00:00
abstract::In this experiment, event-related potentials were used to examine whether the neural correlates of encoding processes predicting subsequent successful recall differed from those predicting successful source memory retrieval. During encoding, participants studied lists of words and were instructed to memorize each word...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32835d8452
更新日期:2013-03-06 00:00:00
abstract::We investigated the cortical activation changes associated with motor recovery in six hemiparetic patients with precentral knob infarct. fMRI at 1.5 T with finger movements at a fixed rate was performed twice in each patient, 1 and 6 months after stroke onset. From the images obtained, the LI (laterality index) for th...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200403010-00002
更新日期:2004-03-01 00:00:00
abstract::We investigated the role of kainate receptor activation in modulating the influx of Ca2+ coupled to the exocytotic release of glutamate in rat hippocampal synaptosomal fractions (P2). In whole hippocampus synaptosomes stimulation with domoic acid increased the intracellular free Ca2+ concentration ([Ca2+]i) in a dose-...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199605170-00023
更新日期:1996-05-17 00:00:00
abstract::Hindlimb unloading (HU) can cause motion and cognition dysfunction, although its cellular and molecular mechanisms are not well understood. The aim of the present study was to determine the stereological parameters of the brain areas involved in motion (motor cortex) and spatial learning - memory (hippocampus) under a...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000675
更新日期:2016-11-09 00:00:00
abstract::Bulbospinal C1 neurons are sympathoexcitatory and excited by substance P. However the substance P receptor (NK1 receptor), has been reported to be absent from the somata of C1 neurons. In this study, using double and triple labelling immunofluorescence and retrograde tracing, we provide evidence that the NK1 receptor ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200112040-00012
更新日期:2001-12-04 00:00:00
abstract:OBJECTIVES:There are subclinical neurologic deficits in cirrhotic patients without overt hepatic encephalopathy. We aimed to use F-fluorodeoxyglucose PET/computed tomography to explore the impaired brain glucose metabolism of subclinical hepatic encephalopathy in cirrhosis. METHODS:Thirty-seven patients with hepatitis...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001284
更新日期:2019-08-07 00:00:00
abstract::delta-9-Tetrahydrocannabinol (THC) is a major psychoactive component of cannabis. We have recently localized a receptor for THC in the forebrain and found in the caudate-putamen that its gene expression is modulated by glucocorticoids, dopamine and glutamate. Here, we report for the first time, using quantitative in s...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199406020-00028
更新日期:1994-06-02 00:00:00
abstract::In an earlier screening, we identified several genes for kinases that might control the extension of neurites. One of these genes encoded a leukocyte tyrosine kinase (LTK), which is a receptor tyrosine kinase whose ligands remain to be identified. To examine the possible role of this LTK in neurite outgrowth, we const...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3283186bf8
更新日期:2008-11-19 00:00:00
abstract::Cell death by apoptosis occurs in mature neurones of adult rat dentate gyrus following adrenalectomy. In these studies, apoptosis in the dentate gyrus was induced 3 days after adrenalectomy in male Fischer 344 rats ranging in age from 2-3 to 24-26 months. Glial fibrillary acidic protein and transforming growth factor-...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199804200-00040
更新日期:1998-04-20 00:00:00
abstract::The distribution of activated NF-kappaB (p65) was studied in granule cells of the rat fascia dentata using confocal laser scanning microscopy and preembedding immunogold electron microscopy. Activated NF-kappaB, detected with a monoclonal antibody specific for the nuclear localization signal-epitope, was found in prox...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200003200-00036
更新日期:2000-03-20 00:00:00
abstract::Short-latency ocular following responses in monkeys, induced by first- and second-order motion during a fixation task, were sensitive to stimulus size, retinal eccentricity and motion duration. Latency of eye movements was no different for first- or second-order motion and simply marked the occurrence of movement in t...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199812010-00039
更新日期:1998-12-01 00:00:00
abstract::Production and differentiation of olfactory neurons occur in spherical, multi-neuronal aggregates that form in cultures where dissociated newborn rat nasal cells are plated on to CNS glial cells. We show here that neuronal cell bodies were primarily located in the peripheral layers of the spheres, and almost every neu...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199401000-00003
更新日期:1994-01-31 00:00:00
abstract::Neurotrophic factors such as brain-derived neurotrophic factor (BDNF) are assumed to provide trophic support via a target-derived, retrograde mechanism of action. However, recent studies suggest that neurotrophic factors can act in an autocrine fashion and perhaps even in an anterograde direction similar to neurotrans...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199705260-00008
更新日期:1997-05-27 00:00:00
abstract::We compared various measures of visual-vestibular interaction in subjects with insulin-dependent diabetes mellitus (IDDM) or non-insulin-dependent diabetes mellitus (NIDDM), as well as non-diabetic controls. Subjects with IDDM exhibited significantly greater postural sway than controls on those conditions in the Clini...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200002280-00012
更新日期:2000-02-28 00:00:00
abstract::We recorded auditory evoked magnetic fields (AEFs) by presenting pure tone bursts once every 4000 ms in 11 patients with a brain lesion in or in the vicinity of the auditory cortex. AEFs on the damaged side revealed several enhanced deflections in late-latency AEFs (slow AEFs), peaking at approximately 320 (DI), 1030 ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200105080-00048
更新日期:2001-05-08 00:00:00
abstract::Prepulse inhibition (PPI) of the acoustic startle reflex is a measure of sensorimotor gating which occurs in both rodents and humans. PPI is deficient in severe neuropsychiatric disorders such as schizophrenia. We investigated PPI in 10 adult monkeys (Cebus apella). Stimuli were 115 dB white noise startle pulses, eith...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200101220-00031
更新日期:2001-01-22 00:00:00
abstract::We examined the effect of stimulus interruption on dual component field EPSPs in the hippocampal CA1 region. Resuming test stimulation at 0.1 Hz after 10-60 min silent periods led to an increase of the response followed by a decline, involving AMPA and NMDA components to a similar extent. Similar changes were seen whe...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199904060-00005
更新日期:1999-04-06 00:00:00
abstract::The present study examined the sleep-wake cycle effects of microinjections of yohimbine, an adrenergic antagonist, and atropine, a cholinergic antagonist, into the cerebral ventricle of clomipramine-induced depressed rats. Yohimbine microinjection caused a significant reduction in the total duration and the number of ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200209160-00006
更新日期:2002-09-16 00:00:00
abstract::With increasing age, the electrophysiological event-related potentials P3a/P3b tend to get a more frontal maximum. The cognitive significance of this so-called frontal shift is not known, but hypotheses have focused on changes in the integrity of the frontal lobes. The aim of the present study was to test how the thic...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000177011.44602.17
更新日期:2005-09-08 00:00:00
abstract::Alpha oscillations during cognitive performance have mostly been studied in memory and/or basic attention tasks. This study investigates task-related alpha power desynchronization during an attentional switching task requiring higher executive attentional control. Low 8-10 Hz and high 10-12 Hz alpha power responses ar...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200204160-00029
更新日期:2002-04-16 00:00:00