Abstract:
:We investigated the role of kainate receptor activation in modulating the influx of Ca2+ coupled to the exocytotic release of glutamate in rat hippocampal synaptosomal fractions (P2). In whole hippocampus synaptosomes stimulation with domoic acid increased the intracellular free Ca2+ concentration ([Ca2+]i) in a dose-dependent manner with an EC50 of 0.16 microM, whereas the EC50 for kainate was 0.86 microM and for (+/-)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) was 43.04 microM. Stimulation of the synaptosomes with 10 microM domoic acid induced Ca(2+)-dependent release of endogenous glutamate. Also, in synaptosomes isolated from the CA3 sub-region of the hippocampus the domoic acid-induced release of glutamate was higher than that from the dentate gyrus (221.3%), from the CA1 (188.1%) or from the whole hippocampal synaptosomes (131.5%). These results support the existence of a presynaptic kainate receptor which may control the exocytotic release of glutamate in the CA3 sub-region of the rat hippocampus.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Malva JO,Carvalho AP,Carvalho CMdoi
10.1097/00001756-199605170-00023subject
Has Abstractpub_date
1996-05-17 00:00:00pages
1330-4issue
7eissn
0959-4965issn
1473-558Xjournal_volume
7pub_type
杂志文章相关文献
NEUROREPORT文献大全abstract::This study examined the potential of embryonic stem cell-derived neurons as transplants for cell therapy for the primary loss of spiral ganglion neurons. To assess the ability of embryonic stem cell-derived neurons for innervation into auditory epithelia, they were cocultured with auditory epithelium explants of mice ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200505310-00001
更新日期:2005-05-31 00:00:00
abstract::Cyclooxygenase (COX)-2 is constitutively expressed in the superficial dorsal horn of the spinal cord, but its role in the spinal cord is still unclear. We examined the effect of intrathecally administered NS398, a selective COX-2 inhibitor and indomethacin, an non-selective COX-1 and COX-2 inhibitor, on the developmen...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199812010-00019
更新日期:1998-12-01 00:00:00
abstract::Melatonin has been shown to exert potent antinociception but the sites and mechanisms of action underlying this effect have not yet been clarified. The effect of melatonin on spinal cord nociceptive transmission was studied in rats by assessing wid-up activity in a C-fiber reflex responses paradigm evoked by repetitiv...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200201210-00021
更新日期:2002-01-21 00:00:00
abstract::In this study, the brainstem-spinal cord preparation isolated from newborn rats, an established model for the study of the hypoxic respiratory depression (HRD), has been used. The comparison of Fos expression in ponto-medullary areas in these preparations placed either in normoxic or hypoxic conditions suggests that o...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200112210-00012
更新日期:2001-12-21 00:00:00
abstract::Whereas facial emotion recognition protocols have shown that each discrete emotion has a specific time course of brain activation, there is no electrophysiological evidence to support these findings for emotional induction by complex pictures. Our objective was to specify the differences between the time courses of br...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000016
更新日期:2013-11-13 00:00:00
abstract::The aim of this study was to reveal a potential effect of emotion on cognitive control in the implicit memory task with emotionally neutral and unpleasant words in healthy controls and patients with schizophrenia using a 3.0 T functional MRI (fMRI). A total of 15 patients with schizophrenia and 15 healthy controls und...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000405
更新日期:2015-08-05 00:00:00
abstract::Humans are able to correct an ongoing movement very quickly in response to a suddenly moving target. Such fast responses possibly bypass the motor cortex and if so, one would expect that damage to the motor cortex would not greatly affect them. A group of children with congenital spastic hemiplegia were asked to move ...
journal_title:Neuroreport
pub_type: 杂志文章,随机对照试验
doi:10.1097/WNR.0b013e32831b0323
更新日期:2009-01-07 00:00:00
abstract::The cellular distribution of the rat metabotropic glutamate receptor type 4 (mGluR4) was examined in the adult rat cerebral cortex and hippocampus. Antibodies were raised against amino acid residues located in the extracellular amino terminal domain that is common to both the mGluR4a and mGluR4b splice variants, and u...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199710200-00031
更新日期:1997-10-20 00:00:00
abstract::The dynamics of intracellular calcium concentration ([Ca2+]i) following activation of low voltage-activated (LVA) and high voltage-activated (HVA) Ca2+ currents were studied in identified relay neurons and interneurons of the rat dorsal lateral geniculate nucleus (LGNd) in situ using Ca2+ imaging and patch-clamp techn...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199707280-00001
更新日期:1997-07-28 00:00:00
abstract::Autopsy material from three patients with Rett syndrome and six control cases (frontal, temporal and motor cortical areas) were studied. Pyramidal and non-pyramidal neurones, 100-200 in each specimen, were visualized by Lucifer Yellow microinjection. 3-D reconstructions and rotations were computed using the VoxelView/...
journal_title:Neuroreport
pub_type: 杂志文章
doi:
更新日期:1994-07-21 00:00:00
abstract::The evaluative processing of the valence of action feedback is reflected by an event-related brain potential component called feedback-related negativity (FRN) or reward positivity (RewP). Recent studies have shown that FRN/RewP is markedly reduced when the action-feedback interval is long (e.g. 6000 ms), indicating t...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000657
更新日期:2016-09-28 00:00:00
abstract::By means of magnetoencephalography we investigated the auditory-evoked fields (AEFs) elicited by broadband noise bursts in a gap-detection paradigm in children. AEFs of 16 healthy children (mean age 8.7 years) were recorded while they passively listened to 100-ms white-noise bursts with temporal gaps of 3, 6, 10 and 3...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3282f0b6e2
更新日期:2007-10-29 00:00:00
abstract::It has been hypothesized that the vomeronasal system (VNS), a complex neural network implicated in the control of reproductive behaviors, is sexually dimorphic. The posteromedial cortical amygdaloid nucleus (PMCo) belongs to the group of amygdaloid structures that receive direct olfactory input from the accessory olfa...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199808030-00042
更新日期:1998-08-03 00:00:00
abstract::Functional homology between human and macaque visual cortices has provided an important cue to functional subdivisions of the human visual cortex, but it is unclear beyond V1. We estimated the sizes and the visual field eccentricity functions of the extrastriate visual areas of human brains using MRI and fMRI measurem...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200308260-00008
更新日期:2003-08-26 00:00:00
abstract::It remains an open question whether the amplitude of N400 reflects combinatory postlexical semantic integration processing. To examine the issue, we repeatedly presented strictly simplified, N400-eliciting three-word structures for seven times, mixed with their plausible counterparts, followed immediately by a much mo...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001108
更新日期:2018-11-07 00:00:00
abstract::The glomerular layer of the olfactory bulb contains a substantial population of dopaminergic neurons. We determined the quantity and location of D1 and D2 dopamine receptors which are the presumed targets of these neurons. Binding of the D1 selective ligand [3H]SCH23390 was slightly above background and was distribute...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199101000-00002
更新日期:1991-01-01 00:00:00
abstract::To achieve neuronal differentiation of mouse bone mesenchymal stem cells (bMSCs) into neuron-like cells and explore the role of miR-122-5p that may regulate T-box brain 1 (Tbr1) expression during the induction. BMSCs were cultured and induced with butylated hydroxyanisole, retinoic acid (RA), basic fibroblast growth f...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000752
更新日期:2017-05-03 00:00:00
abstract::Diffusion tensor imaging (DTI) can non-invasively examine the molecular diffusion of water in vivo and directly reflects the anatomical integrity of neural fibers in white matter. Fractional anisotropy (FA) can be calculated from DTI data, and utilized to evaluate white matter integrity. DTI was performed on 30 patien...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200310060-00015
更新日期:2003-10-06 00:00:00
abstract::Light physiologically regulates the levels of c-Fos in the suprachiasmatic nucleus (SCN), but the identity of most of the cells that express this DNA-binding protein is unknown. To determine whether SCN c-Fos expression is restricted to neurons, we performed light microscopic double-label immunohistochemistry on secti...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199409080-00012
更新日期:1994-09-08 00:00:00
abstract::Oscillatory activity is a ubiquitous property of brain signals, and yet relatively few studies have investigated how the phase of such ongoing oscillations affects our cognition. One of the main findings in this field is that the phase of electroencephalography (EEG) in the alpha band can affect perception of millisec...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001215
更新日期:2019-04-10 00:00:00
abstract::In the adult brain, neural proliferation is almost absent and neurons are generally not renewed. By contrast, in the olfactory organ, olfactory neurons are produced continuously throughout life. To investigate whether specific cell cycle inhibitors are involved in the control of neural quiescence in adulthood, we comp...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200110080-00029
更新日期:2001-10-08 00:00:00
abstract::Differences related to development were investigated using a finger isometric force task in children with cerebral palsy and control children. The increase in force and force control observed in controls did not take place in patients. In the younger subset of patients (< 10 years) the force produced by the non-affect...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200408260-00020
更新日期:2004-08-26 00:00:00
abstract::Neural salient serine/arginine-rich protein 1 (NSSR1) expression has been found in mouse cerebral neurons, cerebellar Purkinje cells, pyramidal neurons and granule cells of dentate gyrus and regulates the pre-mRNA splicing of genes important for neural functions. In this study, we demonstrated that NSSR1 is expressed ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3282f0b542
更新日期:2007-10-29 00:00:00
abstract::The effects of interleukin-1beta in the paraventricular nucleus or caudal arcuate nucleus on hypertensive and tachycardiac responses induced by excitation of the central amygdaloid nucleus were studied. We observed that microinjection of sodium glutamate into central amygdaloid nucleus resulted in hypertension and tac...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200203250-00039
更新日期:2002-03-25 00:00:00
abstract::The potential neuroprotective effects of glial cell line-derived neurotrophic factor (GDNF) and neublastin (NBN) against NMDA-induced excitotoxicity were examined in hippocampal brain slice cultures. Recombinant human GDNF (25-100 ng/ ml) or NBN, in medium conditioned by growth of transfected, NBN-producing HiB5 cells...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200012180-00032
更新日期:2000-12-18 00:00:00
abstract::Palmitoylethanolamine (PEA) is a ligand at peroxisome proliferator-activated receptors-α (PPARα), a nuclear receptor that has anti-inflammatory effects. Herein, complete Freund's adjuvant (CFA)-induced inflammatory pain model in rats and in-vitro calcium imaging studies were used to evaluate the mechanisms that underl...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001161
更新日期:2019-01-02 00:00:00
abstract::Zinc appears to have a role in binding amyloid precursor protein in vitro, but it is not known whether zinc plays a role in senile plaque formation in vivo in humans. Serum zinc concentrations were available from 12 sisters who died in the Nun Study, a longitudinal study of aging and Alzheimer's disease. Fasting serum...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199511000-00002
更新日期:1995-11-13 00:00:00
abstract::Formalin fixation reduces beta-amyloid precursor protein (beta APP) immunoreactivity which restricts its study in archival tissue. Formic acid pretreatment has previously been used in an attempt to overcome this problem, but makes the sections very friable. In the present study, a microwave antigen retrieval method ha...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199405000-00016
更新日期:1994-05-09 00:00:00
abstract::Intraplantar carrageenan induced a peripheral oedema and c-Fos like immunoreactivity (Fos-LI) in L4-L5 segments in the dorsal horn (DH) of the rat spinal cord. The total number of carrageenan evoked Fos-LI neurones was 153 +/- 10 per section, with a predominant localization in the superficial and deep laminae of the D...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199507100-00006
更新日期:1995-07-10 00:00:00
abstract::An fMRI investigation was conducted to determine whether patients with impaired face recognition, a deficit known as prosopagnosia, would show functional activation in the fusiform gyrus, the neural substrate for face processing, when viewing faces. While the patients did show activation in the fusiform gyrus, with si...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200106130-00014
更新日期:2001-06-13 00:00:00