Abstract:
:Diffusion tensor imaging (DTI) can non-invasively examine the molecular diffusion of water in vivo and directly reflects the anatomical integrity of neural fibers in white matter. Fractional anisotropy (FA) can be calculated from DTI data, and utilized to evaluate white matter integrity. DTI was performed on 30 patients with schizophrenia and 19 healthy controls, and their FA values were subsequently measured in multiple brain regions. Statistical analyses revealed that FA values were decreased in the anterior cingulum of schizophrenia subjects. There were no significant differences between patients and controls in any other regions. This study supports the hypothesis that schizophrenia is associated with abnormal white matter integrity of the anterior cingulum.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Sun Z,Wang F,Cui L,Breeze J,Du X,Wang X,Cong Z,Zhang H,Li B,Hong N,Zhang Ddoi
10.1097/00001756-200310060-00015subject
Has Abstractpub_date
2003-10-06 00:00:00pages
1833-6issue
14eissn
0959-4965issn
1473-558Xjournal_volume
14pub_type
杂志文章相关文献
NEUROREPORT文献大全abstract::The aim of this study was to identify differences in structural and functional brain connectivity between poststroke mild and severe motor impairment. Twenty-four chronic stroke patients who underwent resting-state functional MRI and diffusion tensor image were retrospectively included. All patients were classified in...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001247
更新日期:2019-05-01 00:00:00
abstract::We investigated the expression for fibroblast growth factor-2 (FGF-2), in cultured rat cerebellar granule cells and its modulation by Ca2+ regulating agents. There were no significant differences in the levels of FGF-2 mRNA in cells cultured in high vs low K+. The expression of the trophic factor is induced by Ca2+ en...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200011090-00043
更新日期:2000-11-09 00:00:00
abstract::The study aimed to compare the whole-brain gray matter volume (GMV) and white matter volume (WMV) difference between primary angle closure glaucoma (PACG) patients and health controls (HCs) using a voxel-based morphometry method. A total of 27 patients with PACG (17 males and 10 females) and 27 HCs (17 males and 10 fe...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001126
更新日期:2018-11-07 00:00:00
abstract::Dichotic pitches and mistuned harmonics can each lead to the perception of one or two auditory objects. Comparison of event-related potentials for the perception of one versus two objects reveals an early negative and a late positive component. The relationship of these components with auditory segregation was further...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32832c92bf
更新日期:2009-07-01 00:00:00
abstract::Flurothyl kindling initiates a time-dependent process that results in a facilitated propagation from the forebrain to the brainstem seizure system and in an increase in the complexity of behavioral seizure expression. We investigated the involvement of the ventromedial nucleus of the hypothalamus (VMH) in mediating th...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199811160-00013
更新日期:1998-11-16 00:00:00
abstract::Acute injury to central nervous system (CNS) triggers neurodegenerative processes that can result in serious damage or complete loss of function. After injury, production of transforming growth factor β1 (TGFβ1) increases and initiates creation of a fibrotic scar that prevents normal growth, plasticity, and recovery o...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000106
更新日期:2014-03-26 00:00:00
abstract::We examined the biology of AMPA/kainate-induced motor neuron degeneration using dissociated spinal cord cultures and motor neuron-specific antibodies which enable characterization of individual motor neurons in culture. Cobalt, which is thought to pass through Ca2+-permeable AMPA/kainate receptors following kainate ex...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199903170-00034
更新日期:1999-03-17 00:00:00
abstract::The major central nervous system (CNS) myelin proteolipid (PLP) is also expressed in the peripheral nervous system (PNS). This paper gives evidence that DM-20, an isoform of PLP, also occurs in rat sciatic nerves, where, in contrast to what is seen in CNS myelin, it predominates over PLP. This conclusion was reached o...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199102000-00006
更新日期:1991-02-01 00:00:00
abstract::When we look at our spatial environment we have the feeling that the whole visual field is coloured, yet the density of cone photoreceptors decreases considerably as eccentricity increases. We investigated colour perception (coloured/noncoloured), colour naming and whether colour helps object recognition at eccentrici...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000236864.54575.98
更新日期:2006-10-23 00:00:00
abstract::Familial Alzheimer's disease due to presenilin 1 (PSEN1) mutations shows considerable phenotypic variability with differences in neuropathology and neurological symptoms. Spastic paraparesis is a common neurological phenotype associated with Alzheimer's disease arising from PSEN1 mutations. To investigate whether know...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3282405209
更新日期:2007-08-06 00:00:00
abstract::Newly hatched domestic chicks serve as an important model for experimental studies of neural and behavioral plasticity. Brain-derived neurotrophic factor (BDNF) has been shown to play a critical role in synaptic plasticity, including long-term potentiation, which underlies learning and memory in rodents. Here we show ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32834d0be7
更新日期:2011-12-07 00:00:00
abstract::Capsaicin in the adult animal causes antinociception due to the massive release of neurotransmitters, including substance P (SP), from primary afferent C-fibers. The results of the present study indicate that capsaicin-induced antinociception in the adult is sensitive to inhibition by dizocilpine (MK-801). The failure...
journal_title:Neuroreport
pub_type: 杂志文章
doi:
更新日期:1993-09-03 00:00:00
abstract::Microglial activation is thought to contribute to the progression of selective motor neuron death during amyotrophic lateral sclerosis (ALS). As minocycline has been shown to inhibit microglial activation, the therapeutic efficacy of this tetracycline derivative in the G93A mice model for familial ALS was tested. This...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200206120-00018
更新日期:2002-06-12 00:00:00
abstract::Although valproate (VPA) is used widely in the treatment of bipolar mood disorder and epilepsy, the precise mechanism of action in the brain remains elusive. In this study, we investigated the effects of subchronic VPA administrations on the expression of the cyclin-dependent kinase inhibitor (Cdkn) family in the hipp...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000448
更新日期:2015-10-21 00:00:00
abstract::The aim of this study was to determine the changes of the nociceptive thresholds in response to an acute mechanical stimulus (paw pressure) in magnesium (Mg)-deficient rats, and the involvement of the NMDA receptor in these changes. Changes in vocalization thresholds was determined after 7 days of feeding with a Mg-de...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199704140-00013
更新日期:1997-04-14 00:00:00
abstract::The neuroprotective effects of netrin-1 after spinal cord injury and its specific molecular mechanisms have not been elucidated. In our study, Western blot, transferase UTP nick end labeling staining and immunofluorescence staining first showed that netrin-1 significantly decreased the expression levels of caspase-3, ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001441
更新日期:2020-05-07 00:00:00
abstract::PEC-60, a 60-residue intestinal peptide structurally related to the pancreatic secretory type of trypsin inhibitor, has been isolated, characterized and molecularly cloned. It shows biological activity as a hormone in both the gastrointestinal tract and in the immune system. We now report immunohistochemical evidence ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199409080-00033
更新日期:1994-09-08 00:00:00
abstract::Somatostatin sst2(a) receptor was observed, by immunofluorescence, in ependymal cells and in tanycytes of the wall of the ventricle and the hypothalamic recess of the male rat median eminence. Strong immunoreactivity for the receptor protein was observed in lateral tanycytes (alpha-type) while a moderate signal was se...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200107030-00007
更新日期:2001-07-03 00:00:00
abstract::In this study we have used the transgenic mouse model Tg2576 to analyze the involvement of anomalous loss of regulation of cdk5 and the stress kinases JNK and p38 in brain neuronal death as related to neurodegenerative disorders such as Alzheimer's disease. Previous studies on hippocampal cells led us to the discovery...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200312190-00023
更新日期:2003-12-19 00:00:00
abstract::The NMDA receptor is one of the ionotropic glutamate receptors essential for excitatory neurotransmission. The NMDAR1 subunit is inactivated by direct interaction with calmodulin. The protein levels of calmodulin, NMDAR1 and their complex were quantified in tissue resected from epileptogenic and non-epileptogenic cort...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/00001756-199905140-00040
更新日期:1999-05-14 00:00:00
abstract::Hydrogen peroxide (H₂O₂) is a ubiquitous reactive oxygen species that can induce several inner ear disorders. In this study, we recorded the potassium (K) currents in acutely isolated inner hair cells of guinea pig cochlea, and investigated the effects of H₂O₂. We also observed the morphological changes in inner hair ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32833fcb56
更新日期:2010-11-17 00:00:00
abstract:OBJECTIVE:The current study aims to investigate whether computer generated (CG) expressions of emotion evoke similar emotional appraisal processing in the lateral orbitofrontal cortex (lOFC) compared to real human expressions, as well as how speech cues would influence the processing. METHODS:Functional near-infrared ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001420
更新日期:2020-04-08 00:00:00
abstract::Exosomes derived from Schwann cells have been known to have a variety of functions in the development and repair of the peripheral nervous system, and cyclic AMP (cAMP) is a key inducer of Schwann cell differentiation. In the present study, we aimed to study the effect of exosomes derived from differentiated Schwann c...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001435
更新日期:2020-05-07 00:00:00
abstract::We investigated whether short-term saccadic adaptation modifies hand pointing. Subjects were presented with double-step targets, the second target jump occurring during the saccade to the first one and bringing the target back to 66% of the first target eccentricity, in order to reduce the gain of their gaze saccades....
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199509000-00007
更新日期:1995-09-11 00:00:00
abstract::The distribution and modulation of neural cell adhesion molecule polysialylation state (NCAM PSA) and the consequence of antisense inactivation of the Kv1.1 potassium channel was investigated following avoidance learning in mice. PSA immunoreactivity was most notable on cells at the inner denate border and in cortical...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199808240-00008
更新日期:1998-08-24 00:00:00
abstract::The primate pulvinar connects with the entire array of known visual areas and is postulated to play a role in selective visual attention. Recently, five separate neurochemical subdivisions of a region termed the inferior pulvinar (PI) complex were identified in monkeys. In the present study, similar histochemical proc...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199912160-00002
更新日期:1999-12-16 00:00:00
abstract::Net-like structures surrounding several types of neurones contain glycoconjugates which are detectable by lectins specific for N-acetylgalactosamine. Wisteria floribunda agglutinin (WFA) was introduced as a further marker for the visualization of such perineuronal nets, which were also revealed in regions of the rat b...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199210000-00012
更新日期:1992-10-01 00:00:00
abstract::It is a matter of dispute whether or not recurrent epileptic seizures cause neuronal damage in the human brain. We approached this question by measuring the volumes of the amygdala, hippocampus and parahippocampal gyrus with magnetic resonance imaging in 15 controls, 13 unmedicated patients with newly diagnosed epilep...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199412300-00055
更新日期:1994-12-30 00:00:00
abstract::We investigated the mRNA levels of neuronal, inducible, endothelial nitric oxide synthases (nNOS, iNOS, eNOS) and tumor necrosis factor-alpha (TNF-alpha) in a rat dorsal root ganglion (DRG) after tourniquet application to a hind limb to identify molecules that trigger secondary events after peripheral nerve injury. Si...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200312020-00026
更新日期:2003-12-02 00:00:00
abstract::Recently some authors have challenged the conventional association of directional motor neglect with damage of frontal structures, showing that pure sensory perceptual neglect (classically associated with parietal lesion) can follow damage of right frontal cortex. The aim of the present study was to assess the type of...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200212200-00038
更新日期:2002-12-20 00:00:00