Abstract:
:The major central nervous system (CNS) myelin proteolipid (PLP) is also expressed in the peripheral nervous system (PNS). This paper gives evidence that DM-20, an isoform of PLP, also occurs in rat sciatic nerves, where, in contrast to what is seen in CNS myelin, it predominates over PLP. This conclusion was reached on the basis of results obtained by immunoblot analysis of a crude proteolipid extract from adult peripheral nerve with two site-specific anti-proteolipid (PLP and DM-20) antibodies. This finding was further corroborated by characterization of the products obtained by Polymerase Chain Reaction (PCR) amplification of cDNAs synthesized from total RNA of 14-day-old sciatic nerves. The significance of the occurrence of these proteolipids in PNS remains obscure.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Pham-Dinh D,Birling MC,Roussel G,Dautigny A,Nussbaum JLdoi
10.1097/00001756-199102000-00006subject
Has Abstractpub_date
1991-02-01 00:00:00pages
89-92issue
2eissn
0959-4965issn
1473-558Xjournal_volume
2pub_type
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