Abstract:
:Opioid-receptor-like I (ORLI) receptors, ORLI mRNA and nociceptin are particularly abundant in the limbic system and in central monoaminergic areas, brain regions involved in mood regulation and response to antidepressants. To analyse whether ORLI receptors adaptations occur during the first 3 weeks of an antidepressant treatment, we administered paroxetine to rats (10 mg/kg, i.p., once a day) for 4, 7,14 or 21 days. A significant increase (22-50%) in [3H]nociceptin binding sites density appeared specifically in the dorsal raphe nucleus after 4, 7 or 21 days of treatment, whereas no change was observed at any time in any other brain regions studied. These data constitute the first evidence of a modulation of ORLI receptors by an antidepressant treatment.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Vilpoux C,Naudon L,Costentin J,Leroux-Nicollet Idoi
10.1097/00001756-200201210-00026subject
Has Abstractpub_date
2002-01-21 00:00:00pages
111-4issue
1eissn
0959-4965issn
1473-558Xjournal_volume
13pub_type
杂志文章相关文献
NEUROREPORT文献大全abstract::Transplantation of olfactory ensheathing cells (OECs) into photochemically damaged rat spinal cord diminished astrocyte reactivity and parenchyma cavitation. The photochemical lesion performed at T12--L1 resulted in severe damage to the spinal cord, so that during the first 15 days postoperation all rats dragged their...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200108080-00005
更新日期:2001-08-08 00:00:00
abstract::All-night recordings of respiration, ballistocardiogram, and body movements were obtained using the static charge-sensitive bed (SCSB) and automatically analysed data were compared with sleep stages. The mean sum of eight SCSB variability parameters was lowest in slow wave sleep (SWS), higher during stage 2 (S2), and ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199604100-00030
更新日期:1996-04-10 00:00:00
abstract::The distribution of neurones expressing neuropeptide Y (NPY) mRNA in the brain of the goldfish was investigated using a non-radioactive in situ hybridization technique. Neurones expressing NPY mRNA were located in cell groups previously shown to exhibit NPY immunoreactivity in the ventral telencephalon, thalamus, opti...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199412300-00033
更新日期:1994-12-30 00:00:00
abstract:OBJECTIVE:Birdsong sounds are often used to inform visually-challenged people about the presence of basic infrastructures, and therefore need to be salient in noisy urban environments. How salient sounds are processed in the brain could inform us about the optimal birdsong in such environments. However, brain activity ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001563
更新日期:2021-01-13 00:00:00
abstract::The regulation of glucocorticoid receptors and nuclear factor kappaB was evaluated in the spiral ganglion neurons after 4 h of restraint stress in the mouse cochlea. Immediately after restraint stress, glucocorticoid receptor protein expression was not altered in spiral ganglion neurons even though both the plasma cor...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000220131.24468.e7
更新日期:2006-06-26 00:00:00
abstract::Successful practice of clinical deep brain stimulation (DBS) calls for basic research on the mechanisms and explorations of new indications in animals. In the article, a new implantable, single-channel, low-power miniature device is proposed, which may transmit pulses chronically into the brain nucleus of freely movin...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000727
更新日期:2017-02-08 00:00:00
abstract::Mammalian TIMELESS (TIM) was identified due to its sequence similarity to Drosophila TIM, an essential circadian clock protein in flies. Published literature is inconsistent regarding the rhythmic expression of mammalian Tim, the interaction of the TIM protein with other clock proteins and its role in regulating clock...
journal_title:Neuroreport
pub_type: 杂志文章,评审
doi:10.1097/01.wnr.0000233092.90160.92
更新日期:2006-08-21 00:00:00
abstract::In an earlier screening, we identified several genes for kinases that might control the extension of neurites. One of these genes encoded a leukocyte tyrosine kinase (LTK), which is a receptor tyrosine kinase whose ligands remain to be identified. To examine the possible role of this LTK in neurite outgrowth, we const...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3283186bf8
更新日期:2008-11-19 00:00:00
abstract::To analyze an auditory scene, the segregation of the input into separate streams of information is necessary. Here, the mismatch negativity (MMN) of the event-related potential was used to trace the number of simultaneously monitored streams in auditory scene analysis. Subjects passively listened to sounds belonging t...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200305060-00019
更新日期:2003-05-06 00:00:00
abstract::The objective of this study was to investigate the effects of long-term mental abacus calculation training (MACT) on children's spatial attention orientation. Fifteen children with intensive MACT (MACT group) and 15 children without MACT (non-MACT group) were selected. The two groups of children were matched in age, s...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000705
更新日期:2017-01-01 00:00:00
abstract::Event-related potentials(ERPs) were measured while subjects were constructing mental images of a letter of the alphabet. Following presentation of an uppercase letter, subjects were asked to form a mental image of the same letter in lower case, and determine whether or not it had an ascending or descending stroke (asc...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199810260-00004
更新日期:1998-10-26 00:00:00
abstract::STC-1 cells have been established as an enteroendocrine cell line from the small intestine. By monitoring the level of intracellular Ca using a calcium-imaging technique, cellular responses of intestinal STC-1 cells to compounds of five basic tastants were investigated. Although this cell line was known to respond to ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3282f242d3
更新日期:2007-12-03 00:00:00
abstract::This study provides evidence for the role of semantic composition in compound word processing. We examined the online processing of isolated two meaning unit compounds in Chinese, a language that uses compounding to 'disambiguate' meaning. Using auditory presentation, we manipulated the semantic meaning and syntactic ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3282fc1eb7
更新日期:2008-04-16 00:00:00
abstract::The autoradiographic distribution of Ca(2+)-sensitive high- and low-affinity binding sites for the N-type calcium channel ligand, [125I]omega-conotoxin GVIA, has been examined in rat brain. Both classes of sites were rather evenly distributed, exhibiting their highest density in cell body rich layers, such as the pyra...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199405000-00025
更新日期:1994-05-09 00:00:00
abstract::The effects of Type I adrenal steroid receptors in prolonging synaptic plasticity in the dentate gyrus of freely behaving rats was investigated. Rats were implanted with chronic, bilateral stimulating and recording electrodes in the perforant pathway and dentate gyrus, respectively, and adrenalectomized (ADX). After a...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199412000-00067
更新日期:1994-12-20 00:00:00
abstract::Brain activation of 11 healthy right-handed subjects was studied with magnetoencephalography to estimate individual hemispheric dominance for speech sounds. The auditory stimuli comprised binaurally presented Finnish vowels, tones, and piano notes in groups of two or four stimuli. The subjects were required to detect ...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/00001756-199909290-00021
更新日期:1999-09-29 00:00:00
abstract::Recent study has demonstrated that high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) have the same effect to alleviate β-amyloid pathology in the hippocampus of APPswe/PS1dE9 (APP/PS1) mice. Activation of nucleotide binding and oligomerization domain-like receptor family pyrin d...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001429
更新日期:2020-03-25 00:00:00
abstract::Using NADPH-diaphorase (NADPH-d) staining as a marker for the enzyme nitric oxide synthase (NOS) we investigated the possible sites of nitric oxide (NO) synthesis in the olfactory pathways of an insect brain. Staining of frozen sections revealed NADPH-d activity in neurones and in glial cells. A cluster of intensely s...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199501000-00025
更新日期:1995-01-26 00:00:00
abstract::This study examined 'prepulse inhibition' in the context of an auditory two-tone discrimination task performed by 15 healthy subjects. In order to distinguish between masking or excitatory information processes, weak acoustic pulses immediately preceded or succeeded a target or non-target tone in the discrimination. B...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/00001756-199601310-00065
更新日期:1996-01-31 00:00:00
abstract::The aim of this study was to investigate the effects of congenital human cytomegalovirus infection on the expression levels of N-methyl-D-aspartate receptors (NRs) and Ca/calmodulin-dependent protein kinase II (CaMKII) in the hippocampal neurons of neonatal Sprague-Dawley (SD) rats. Pregnant SD rats were divided into ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000750
更新日期:2017-03-22 00:00:00
abstract::The mechanisms underlying the prolonged antidepressant effects after a single infusion of ketamine are only partially understood. Ketamine's half-life of ∼2 h cannot explain antidepressant effects that last for 1 week, suggesting the triggering of long-lasting neuroplasticity. Recent human pharmacokinetics (PK) data i...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001131
更新日期:2018-11-07 00:00:00
abstract::Voltage-dependent outward currents were examined in CA1 neurones by whole-cell recording in slices. Nine cells were recorded with the 'standard' internal solution (KMeSO4, HEPES, EGTA, CaCl2, and MgCl2) and held a potential (-54 +/- 3 mV) at which there was no significant outward current. Cromakalim (CROM, 100 microM)...
journal_title:Neuroreport
pub_type: 杂志文章
doi:
更新日期:1994-06-27 00:00:00
abstract::The hippocampus is the key structure for learning and memory in mammals and long-term potentiation (LTP) is an important cellular mechanism responsible for learning and memory. The influences of norepinephrine (NE) on the modulation of learning and memory, as well as LTP, through β-adrenoceptors are well documented, w...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000679
更新日期:2016-11-09 00:00:00
abstract::We describe the use of an immunoblotting technique to investigate the potential role of reaction oxygen species in the pathogenesis of Duchenne muscular dystrophy. Quadriceps femoris muscle biopsy samples were obtained from six patients with Duchenne and six with Becker muscular dystrophy, and from six control subject...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199807130-00010
更新日期:1998-07-13 00:00:00
abstract::Stimulation of the Schaffer collateral projection to the CA1 region in rat hippocampal slices at 1 Hz for 15 min produced a N-methyl-D-aspartate (NMDA) receptor-dependent long-term depression (LTD) of synaptic responses and, when given after tetanic stimulation, reversed long-term potentiation (LTP). Both LTD and the ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:
更新日期:1993-09-01 00:00:00
abstract::The in-vivo extracellular release of acetylcholine (ACh) from the striatum of rats was measured by intracerebral microdialysis. The ACh levels were first estimated under normoxic conditions, after which the rats were exposed to either 10% or 5% oxygen for 1 h. The average ACh content was 2.9 pmol/20 min. During hypoxi...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199011000-00005
更新日期:1990-11-01 00:00:00
abstract::Electroconvulsive therapy (ECT) is an appropriate clinical model to investigate blood flow during seizures. In this study cerebral blood flow velocity (CBFV) was measured during 40 ECTs in 10 patients by means of transcranial Doppler sonography. EEG was recorded continuously. Under general anesthesia, the pre-convulsi...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/00001756-199802160-00009
更新日期:1998-02-16 00:00:00
abstract::It has been hypothesized that the vomeronasal system (VNS), a complex neural network implicated in the control of reproductive behaviors, is sexually dimorphic. The posteromedial cortical amygdaloid nucleus (PMCo) belongs to the group of amygdaloid structures that receive direct olfactory input from the accessory olfa...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199808030-00042
更新日期:1998-08-03 00:00:00
abstract::The apolipoprotein E (apoE) gene has been identified as a susceptibility gene for Alzheimer's disease, although the mechanism whereby apoE exerts this effect has not been determined. The aim of this study was to examine the intracellular fate of apoE and we demonstrate that in mammalian cells-transiently expressing ta...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199604100-00010
更新日期:1996-04-10 00:00:00
abstract::The current study investigated whether an ipsilesional bias in line bisection, a conventional measure for diagnosing hemispatial neglect, persists even in the absence of this syndrome in patients with chronic lesions restricted to posterior association cortex or dorsolateral prefrontal cortex. Both left and right hemi...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199910190-00004
更新日期:1999-10-19 00:00:00