Type I adrenal steroid receptors prolong hippocampal long-term potentiation.

Abstract:

:The effects of Type I adrenal steroid receptors in prolonging synaptic plasticity in the dentate gyrus of freely behaving rats was investigated. Rats were implanted with chronic, bilateral stimulating and recording electrodes in the perforant pathway and dentate gyrus, respectively, and adrenalectomized (ADX). After a 2-3 day recovery period, baseline recordings of field potentials were made followed by administration of aldosterone or vehicle. One hour later, high frequency stimulation (HFS; chosen to produce comparable long-term potentiation (LTP) in the aldosterone-treated and control groups) was applied unilaterally and recording was continued for 1 h and again performed at 3, 24 and 48 h. LTP in ADX controls decayed significantly within 3 h, and returned to baseline levels at 24 h. In contrast, the aldosterone-treated animals showed enhanced LTP at 3, 24 and 48 h. These findings demonstrate that aldosterone both enhances and prolongs hippocampal plasticity.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Pavlides C,Kimura A,Magariños AM,McEwen BS

doi

10.1097/00001756-199412000-00067

subject

Has Abstract

pub_date

1994-12-20 00:00:00

pages

2673-7

issue

18

eissn

0959-4965

issn

1473-558X

journal_volume

5

pub_type

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