Lack of response to epidermal growth factor in adult neural progenitor cells.

abstract：:Groups of 20 C57BL/6J mice (10 males and 10 females) were given BSE strain 301C i.p. and subsequently given 2 microg recombinant human TGFbeta1 s.c. at single or multiple times. There was a significant positive correlation between the day of TGFbeta1 administration and incubation time; the later TGFbeta1 was administe...

journal_title：Neuroreport

authors： Kempster S,Collins ME,Edington N

更新日期：2004-10-05 00:00:00

abstract：:It is difficult to induce long-term potentiation (LTP) in CA1 of hippocampal slices from 120-day-old rats when a single 100 Hz, 1 s tetanus is administered in extracellular solution containing 2.0 mM calcium and 2.0 mM magnesium. However, in the presence of 2.5 mM calcium and 1.3 mM magnesium LTP is reliably induced b...

journal_title：Neuroreport

authors： Izumi Y,Zorumski CF

更新日期：1998-11-16 00:00:00

abstract：:Caspase-2 has features of both initiator and effector caspases. Previously, we have shown that brain hypoxia-induced production of caspases 1, 3, 8, and 9 is Src kinase mediated, a nonreceptor intracellular family of kinases. The present study tests the hypothesis that hypoxia results in increased expression of caspas...

journal_title：Neuroreport

authors： Angelis D,Delivoria-Papadopoulos M

更新日期：2017-08-16 00:00:00

abstract：:A number of epidemiological studies suggest that estrogen therapy is linked to a reduced risk of developing Alzheimer's disease (AD). The present study was conducted to evaluate the effect of 17beta-estradiol on beta-amyloid (Abeta)-induced toxicity and was performed in rat pheochromocytoma PC 12 cells by measuring th...

journal_title：Neuroreport

authors： Svensson AL,Nordberg A

更新日期：1999-11-26 00:00:00

abstract：:This fMRI study explores brain regions involved with perceptual enhancement afforded by observation of visual speech gesture information. Subjects passively identified words presented in the following conditions: audio-only, audiovisual, audio-only with noise, audiovisual with noise, and visual only. The brain may use...

journal_title：Neuroreport

authors： Callan DE,Jones JA,Munhall K,Callan AM,Kroos C,Vatikiotis-Bateson E

更新日期：2003-12-02 00:00:00

abstract：:A synchronizing volley of excitation was delivered to cells from the primary visual cortex of the anaesthetized cat by an electrical pulse stimulation of the optic radiations. In intracellular records, this resulted in an initial, fast depolarization of the membrane potential followed by a longer lasting (266 ms) hype...

journal_title：Neuroreport

authors： Ahmed B

更新日期：2000-04-27 00:00:00

abstract：:The serotonin transporter is a strong candidate for aetiological involvement in affective disorders and psychosis. We analysed a VNTR in intron 2 of the human serotonin transporter gene (hSERT) for allelic association with bipolar affective disorder, unipolar depression and schizophrenia. An increased frequency of all...

journal_title：Neuroreport

authors： Collier DA,Arranz MJ,Sham P,Battersby S,Vallada H,Gill P,Aitchison KJ,Sodhi M,Li T,Roberts GW,Smith B,Morton J,Murray RM,Smith D,Kirov G

更新日期：1996-07-08 00:00:00

abstract：:We analysed the effects of morphine microinjections (0.2 microliter) into the subnucleus oralis (SNO), i.e. the rostral division of the spinal trigeminal nucleus, on the formalin test adapted for orofacial pain. Duration of rubbing following an injection (50 microliters) of formalin solution (1.5%) in the right upper ...

journal_title：Neuroreport

authors： Luccarini P,Cadet R,Saade M,Woda A

更新日期：1995-01-26 00:00:00

abstract：:Formalin fixation reduces beta-amyloid precursor protein (beta APP) immunoreactivity which restricts its study in archival tissue. Formic acid pretreatment has previously been used in an attempt to overcome this problem, but makes the sections very friable. In the present study, a microwave antigen retrieval method ha...

journal_title：Neuroreport

authors： Sherriff FE,Bridges LR,Jackson P

更新日期：1994-05-09 00:00:00

abstract：:A polymorphism of the apolipoprotein E gene, in particular the epsilon 4 allele (ApoE4), has been associated with impaired neuronal phospholipid metabolism and synapse reorganization and has been implicated in several neurodegenerative disorders. Since selective neuronal cell lose and aberrant axonal reorganization re...

journal_title：Neuroreport

authors： Blümcke I,Brockhaus A,Scheiwe C,Rollbrocker B,Wolf HK,Elger CE,Wiestler OD

更新日期：1997-03-24 00:00:00

abstract：:The effect of chronic treatment with vitamin E (VE) on acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity, as assessed by striatal dopamine (DA) depletion, was studied. Male C57B1/6J mice were fed VE (48 mg kg-1 per day, intragastric) for 4, 8, or 12 weeks prior to administration of MPTP (...

journal_title：Neuroreport

authors： Gong L,Daigneault EA,Acuff RV,Kostrzewa RM

更新日期：1991-09-01 00:00:00

abstract：:Hemispheric (re-)organization of episodic memory functions after temporal lobe damage (TLD) was investigated by the intracarotid amobarbital procedure in patients suffering temporal lobe epilepsy. Memory of the speech-dominant left hemisphere was intact after right-sided TLD independent of the age at manifestation. In...

journal_title：Neuroreport

authors： Jokeit H,Ebner A,Holthausen H,Markowitsch HJ,Tuxhorn I

更新日期：1996-07-08 00:00:00

abstract：:Chronic ethanol exposure is known to alter the polyphosphoinositide (poly-PI) signaling pathway, although the exact sight of regulation is not well understood. In this study, C57B1/6J mice were given a control or an ethanol (6 g kg-1 body wt) liquid diet by gastric intubation daily for 4 weeks. Examination of levels o...

journal_title：Neuroreport

authors： Simonyi A,Zhang JP,Sun AY,Sun GY

更新日期：1996-09-02 00:00:00

abstract：:Investigating the neural substrates of auditory processing of absolute pitch musicians has relevance for understanding the capabilities of the human brain for plasticity. Electroencephalography was used to examine the N1 of auditory-evoked potentials from absolute pitch musicians, nonabsolute pitch musicians, and nonm...

journal_title：Neuroreport

authors： Wu C,Kirk IJ,Hamm JP,Lim VK

更新日期：2008-05-28 00:00:00

abstract：:Substantial evidence suggests a negative association between cigarette smoking and the incidence and severity of ulcerative colitis, a common human inflammatory bowel disease. Nicotine has been implicated in this association. The detection of nicotinic acetylcholine receptors in colonic epithelium, the primary tissue ...

journal_title：Neuroreport

authors： Orr-Urtreger A,Kedmi M,Rosner S,Karmeli F,Rachmilewitz D

更新日期：2005-07-13 00:00:00

abstract：:The pathogenesis of amyotrophic lateral sclerosis remains poorly understood, but microglial and astroglial activation are thought to contribute to motor neuron death. Evidence suggests that matrix metalloproteinase-9 (MMP-9) is a mediator of this deleterious effect. In this study, we evaluated the effect of MMP-9 on t...

journal_title：Neuroreport

authors： Dewil M,Schurmans C,Starckx S,Opdenakker G,Van Den Bosch L,Robberecht W

更新日期：2005-03-15 00:00:00

abstract：:S100B is a calcium binding protein from astrocytes that regulates protein phosphorylation by binding to substrates and protein kinases. S100B might also regulate protein phosphatases and this was investigated for protein phosphatase 2B (calcineurin). The results indicate that S100B (5-10 microM) increased the activity...

journal_title：Neuroreport

authors： Leal RB,Frizzo JK,Tramontina F,Fieuw-Makaroff S,Bobrovskaya L,Dunkley PR,Gonçalves CA

更新日期：2004-02-09 00:00:00

abstract：:Behavioral and neuropsychological studies suggest that upright and inverted face stimuli are processed by computationally and anatomically distinct systems. Specifically, inverted faces seem to be addressed by general object perception systems, avoiding face-specific processes. We tested this model by examining the fM...

journal_title：Neuroreport

authors： Aguirre GK,Singh R,D'Esposito M

更新日期：1999-01-18 00:00:00

abstract：:Matrix metalloproteinases (MMPs) may contribute to tissue damage after cerebral ischemia. In this study, wildtype and MMP-2 knockout mice were subjected to permanent and transient (2 h) occlusions of the middle cerebral artery. Gelatin zymography showed that MMP-9 levels were increased in all brains after ischemia. MM...

journal_title：Neuroreport

authors： Asahi M,Sumii T,Fini ME,Itohara S,Lo EH

更新日期：2001-09-17 00:00:00

abstract：:The distribution of neurones expressing neuropeptide Y (NPY) mRNA in the brain of the goldfish was investigated using a non-radioactive in situ hybridization technique. Neurones expressing NPY mRNA were located in cell groups previously shown to exhibit NPY immunoreactivity in the ventral telencephalon, thalamus, opti...

journal_title：Neuroreport

authors： Vecino E,Perez MT,Ekström P

更新日期：1994-12-30 00:00:00

abstract：:Changes of serum immunoglobulin (Ig) concentrations may occur in both brain tumours and lumbar disc diseases (LDD). The purpose of this study was to investigate the changes of pre- and post-operative serum Ig levels in brain tumours and LDDs. Serum IgG, IgA and IgM levels were measured in 127 patients with brain tumou...

journal_title：Neuroreport

authors： Yüceer N,Arasil E,Temiz C

更新日期：2000-02-07 00:00:00

abstract：:Because salicylate is known to produce tinnitus in humans and animals, the effect of salicylate on the auditory system of gerbils was investigated using [14C]2-deoxyglucose (2-DG). Salicylate treatment reduced activity in the inferior colliculus (IC), particularly in the high frequency part, whereas activation along s...

journal_title：Neuroreport

authors： Wallhäusser-Franke E,Braun S,Langner G

更新日期：1996-07-08 00:00:00

abstract：:The present investigation provide evidences from a non-human primate model that naturally occurring menopause predicts a prominent signature of age-related cognitive decline. Young and aged rhesus monkeys were tested on a delayed response (DR) task known to the sensitive to aging, and reproductive status was evaluated...

journal_title：Neuroreport

authors： Roberts JA,Gilardi KV,Lasley B,Rapp PR

更新日期：1997-05-27 00:00:00

abstract：:Magnetic brain responses were recorded to clarify the cortical representation of vowel processing in Japanese. We investigated the peak latencies and equivalent current dipoles of the auditory N1m responses to the Japanese vowels [a], [i], [o], and [u]. In intraindividual analyses for a single participant, well-replic...

journal_title：Neuroreport

authors： Ogata E,Yumoto M,Itoh K,Sekimoto S,Karino S,Kaga K

更新日期：2006-07-31 00:00:00

abstract：:The parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridine (MPP+) acts through inhibition of complex I of the electron transport chain. Recent evidence suggests that it may also act through inhibition of 2-ketoglutarate dehydrogenase complex (KDHC). We confirmed this observation in isolated rat liver mitochondria ...

journal_title：Neuroreport

authors： Joffe GT,Parks JK,Parker WD Jr

更新日期：1998-08-24 00:00:00

abstract：:To investigate how pheromonal information is processed in the rat accessory olfactory bulb, we optically imaged intrinsic signals to obtain high-resolution maps of activation induced by urinary stimulation. Application of volatile components in male urine mainly induced activation in the anterior accessory olfactory b...

journal_title：Neuroreport

authors： Sugai T,Yoshimura H,Kato N,Onoda N

更新日期：2006-11-06 00:00:00

abstract：:Freshly dissected and dissociated subventricular zone cells from adult male mice were transplanted into the right cerebral cortex of adult female mice. Host mice were perfused 3 or 7 weeks later. To detect donor male cells, paraffin sections (10 microm) were hybridized in situ with a Y-chromosome-specific probe. Some ...

journal_title：Neuroreport

authors： Harvey AR,Symons NA,Pollett MA,Brooker GJ,Bartlett PF

更新日期：1997-12-22 00:00:00

abstract：:Brain activation of 11 healthy right-handed subjects was studied with magnetoencephalography to estimate individual hemispheric dominance for speech sounds. The auditory stimuli comprised binaurally presented Finnish vowels, tones, and piano notes in groups of two or four stimuli. The subjects were required to detect ...

journal_title：Neuroreport

authors： Gootjes L,Raij T,Salmelin R,Hari R

更新日期：1999-09-29 00:00:00

abstract：:Using NADPH-diaphorase (NADPH-d) histochemistry, the expression of nitric oxide synthase (NOS) was studied in the rat brain 1 week after kainate-induced status epilepticus. Major changes were observed in the hippocampi of epileptic animals, especially a loss of NADPH-d positive fibres in the periphery of degenerative ...

journal_title：Neuroreport

authors： Lerner-Natoli M,de Bock F,Bockaert J,Rondouin G

更新日期：1994-12-20 00:00:00

abstract：:Evidence exists that motilin immunoreactivity is highly expressed in Purkinje cells. In this study, immunohistochemistry and whole-cell patch-clamp recording were performed to investigate the spatial distribution and electrophysiological effects of motilin receptors in the cerebellum. We show here that motilin recepto...

journal_title：Neuroreport

authors： Chen H,Chen L,Wang JJ,Wei HJ,Yung WH

更新日期：2007-08-27 00:00:00