Abstract:
:Matrix metalloproteinases (MMPs) may contribute to tissue damage after cerebral ischemia. In this study, wildtype and MMP-2 knockout mice were subjected to permanent and transient (2 h) occlusions of the middle cerebral artery. Gelatin zymography showed that MMP-9 levels were increased in all brains after ischemia. MMP-2 levels did not show a significant increase in wildtype mice, and were not detectable in knockout mice. Laser doppler flowmetry demonstrated equivalent ischemic reductions in perfusion in wildtype and knockout mice. In both permanent and transient occlusion paradigms, there were no statistically significant differences between wildtype and knockout mice in terms of 24 h ischemic lesion volumes. These data suggest that MMP-2 does not contribute to acute tissue damage in this model of focal ischemia.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Asahi M,Sumii T,Fini ME,Itohara S,Lo EHdoi
10.1097/00001756-200109170-00050subject
Has Abstractpub_date
2001-09-17 00:00:00pages
3003-7issue
13eissn
0959-4965issn
1473-558Xjournal_volume
12pub_type
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