Abstract:
:Recent reports have suggested the existence of a causal relationship between impaired regression of multiple climbing fibre innervation and impaired motor coordination in protein kinase C gamma subunit (PKC gamma) mutant mice. In the present patch-clamp study, performed in thin cerebellar slices prepared from adult mutant mice deficient in metabotropic glutamate receptors of the mGluR1 subtype, only 15% of Purkinje cells remained multiply innervated by climbing fibres, but motor coordination was largely impaired in these animals. The present results do not preclude the existence of a causal relationship between impairement of regression of multiple innervation during development and improper motor coordination in the adult.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Levenes C,Daniel H,Jaillard D,Conquet F,Crépel Fdoi
10.1097/00001756-199701200-00038subject
Has Abstractpub_date
1997-01-20 00:00:00pages
571-4issue
2eissn
0959-4965issn
1473-558Xjournal_volume
8pub_type
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