Activation of multiple transcription factor genes by tetrahydrocannabinol in rat forebrain.

Abstract:

:delta-9-Tetrahydrocannabinol (THC) is a major psychoactive component of cannabis. We have recently localized a receptor for THC in the forebrain and found in the caudate-putamen that its gene expression is modulated by glucocorticoids, dopamine and glutamate. Here, we report for the first time, using quantitative in situ hybridization, that acute THC (5 mg kg-1, i.p.) regulates the mRNA levels of multiple immediate early genes in the adult rat forebrain. Twenty minutes after a single THC injection, significant increases in concentration of the mRNAs for C-FOS, C-JUN and ZIF-268 were observed in the cingulate cortex (75, 45 and 37%) and for C-FOS and ZIF-268 in the fronto-parietal cortex (60 and 64%) and caudate-putamen (81 and 32%) while JUN-D mRNA levels were not changed. These transcription factor genes might mediate putative THC modulation of neurotransmitter gene expression.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Mailleux P,Verslype M,Preud'homme X,Vanderhaeghen JJ

doi

10.1097/00001756-199406020-00028

subject

Has Abstract

pub_date

1994-06-02 00:00:00

pages

1265-8

issue

10

eissn

0959-4965

issn

1473-558X

journal_volume

5

pub_type

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