Abstract:
:Amyloid beta-peptide (A beta) is a major component of neuritic plaques, a feature of Alzheimer's disease (AD) brains. Recently, we showed that A beta adopts two major conformational states in solution, which differ in their abilities to form amyloid. These are highly amyloidogenic conformer (A beta ac) with a high content of beta-sheet and a slowly amyloidogenic conformer (A beta nac) with a random coil conformation. Apolipoprotein E (apoE), particularly the E4 isoform, which is genetically associated with AD, binds to A beta and modulates fibrillogenesis in vitro. In the present work, the influence of apoE on the conformation of A beta peptides was studied. The results suggest that, under the conditions used, apoE enhances amyloid formation by inducing the conformational transition from A beta nac into A beta ac. We propose that an important step in A beta fibrillogenesis is the transformation induced by apoE of the soluble non-amyloidogenic into the pathological amyloidogenic conformer of A beta.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Soto C,Golabek A,Wisniewski T,Castaño EMdoi
10.1097/00001756-199602290-00010subject
Has Abstractpub_date
1996-02-29 00:00:00pages
721-5issue
3eissn
0959-4965issn
1473-558Xjournal_volume
7pub_type
杂志文章相关文献
NEUROREPORT文献大全abstract::In this study, we examined the expression of insulin-like growth factor I (IGF-I) and its receptor (IGF-IR) in dorsal root ganglia (DRG) neurons in two rodent models of nerve injury: sciatic nerve axotomy and streptozotocin-induced (STZ) painful diabetic neuropathy. We demonstrate that IGF-I and its receptor are prefe...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200209160-00016
更新日期:2002-09-16 00:00:00
abstract::The present paper reports how aluminium [Al(III)] at a concentration of 3.7 microM can activate the bovine erythrocytic enzyme acetylcholinesterase (AChE) by about 38% in vitro. This same activating effect was observed on AChE form human as well as from rat erythrocyte ghosts and murine neuroblastoma cells. The intera...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199409080-00023
更新日期:1994-09-08 00:00:00
abstract::Inconsistencies in previous attempts to localize the N2 wave in the GO/NOGO task led to the present investigation. The inconsistencies were probably because of heterogeneity of psychological operations involved in GO/NOGO tasks. We applied the independent component analysis to a collection of individual event-related ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3283309cbd
更新日期:2009-12-09 00:00:00
abstract::Three SNARE proteins, SNAP-25, syntaxin 1A, and VAMP2 or synaptobrevin 2, constitute the minimal functional machinery needed for the regulated secretion of neurotransmitters. Dynamic changes in the regulated release of neurotransmitters are associated with the induction of long-term plasticity at central synapses. In-...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001258
更新日期:2019-07-03 00:00:00
abstract::In an earlier screening, we identified several genes for kinases that might control the extension of neurites. One of these genes encoded a leukocyte tyrosine kinase (LTK), which is a receptor tyrosine kinase whose ligands remain to be identified. To examine the possible role of this LTK in neurite outgrowth, we const...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3283186bf8
更新日期:2008-11-19 00:00:00
abstract::Electrophysiological studies have shown that somatostatin (SOM; 10(-8) and 10(-7) M) causes a hyperpolarization of the majority of astrocytes in explant cultures of rat spinal cord and cortex. When SOM and the cholinergic agonists muscarine and nicotine (10(-6) M) were tested on the same cell, all three compounds prod...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199407000-00015
更新日期:1994-07-21 00:00:00
abstract::Target detection is the process of bringing a salient stimulus into conscious awareness. Target detection evokes a prominent event-related potential (ERP) component (P3) in the electroencephalogram (EEG). We combined the high spatial resolution of functional magnetic resonance imaging (fMRI) with the high temporal res...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00001756-199709290-00007
更新日期:1997-09-29 00:00:00
abstract::Hypoxia-induced changes in intracerebral arterioles, the major determinants of local cerebral oxygen delivery, are not well understood. Hippocampal arteriolar diameters were measured in rat brain slices using computerized videomicroscopy. In group 1 (control), artificial cerebrospinal fluid oxygen tension (PO2) was ma...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199805110-00031
更新日期:1998-05-11 00:00:00
abstract::The present study examined potential neuroprotective effects of HU-211, a synthetic non-psychotropic cannabinoid with non-competitive NMDA antagonist properties on neurones exposed to various excitotoxins in culture. HU-211 was found to protect neurones from NMDA and quisqualate-induced toxicity but not that produced ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199312000-00013
更新日期:1993-12-13 00:00:00
abstract::One problem in motor control concerns the mechanism whereby the central nervous system translates the motor cortical command encoded in cell activity into a coordinated contraction of limb muscles to generate a desired motor output. This problem is closely related to the design of adaptive systems that transform neuro...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199611040-00038
更新日期:1996-11-04 00:00:00
abstract::We studied whether pro-survival Akt was activated after transient focal cerebral ischemia and whether it inhibited pro-apoptotic Bad. Phosphorylation of Akt (serine-473) was enhanced in cortex after 1-hour ischemia, and also after 1h and 6 h of reperfusion, but it returned back to that in controls by 24 h. After this ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200110290-00046
更新日期:2001-10-29 00:00:00
abstract::To investigate the possibility that insulin-stimulated glucose uptake in C6 cells is due to transactivation of a G protein-mediated pathway, the role of Gq alpha in insulin signaling was studied. Insulin stimulation of [3H]2-deoxy-D-glucose (2DG) uptake by C6 cells was time- and concentration-dependent: at a concentra...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199707070-00051
更新日期:1997-07-07 00:00:00
abstract::We examined the neural correlates associated with a short gap between two identical pure tones (within-channel) and between two different tones (between-channel) in an odd-ball paradigm. Gap durations were selected such that a gap between identical tones was as discriminable as a gap between two different tones. Spati...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200409150-00011
更新日期:2004-09-15 00:00:00
abstract::The effect of olfactory deprivation on cellular expression of the Bcl-2 gene in the olfactory bulb of young rats was investigated. Restriction of olfactory stimuli caused an overall increase in Bcl-2 mRNA expression, with increases seen in the lateral aspects of glomerular, external plexiform, mitral and granule cell ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:
更新日期:1995-12-29 00:00:00
abstract::Recently, we have demonstrated that bone marrow stem cells can differentiate into retinal nerve cells. In the present study, we show a new and efficient strategy for transplanting bone marrow stem cells into the retina. When bone marrow stem cells were injected into the vitreous cavity of untreated eyes, only very few...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000176517.96475.18
更新日期:2005-08-22 00:00:00
abstract::The aim of the present study was to examine the effects of nicotinamide, a co-factor in the electron transport chain, on the relationship between methamphetamine (MA)-induced striatal dopamine (DA) depletion and energy metabolism change. Four injections of MA (10 mg/kg, i.p.) at 2 h intervals resulted in decreases of ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199705260-00018
更新日期:1997-05-27 00:00:00
abstract::Meditation is a conscious mental process that induces a set of integrated physiologic changes termed the relaxation response. Functional magnetic resonance imaging (fMRI) was used to identify and characterize the brain regions that are active during a simple form of meditation. Significant (p<10(-7)) signal increases ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:
更新日期:2000-05-15 00:00:00
abstract::In this study we investigated the utility of different MRI techniques for the detection and predictability of hemorrhagic transformation (HT) in a rat model of transient focal cerebral ischemia. Hemorrhagic infarction was reliably identified with gradient-echo sequences and developed between 2 and 7 days following the...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200102120-00025
更新日期:2001-02-12 00:00:00
abstract::Both acute and chronic exercise is consistently associated with a number of benefits to physical and mental health, including cardiovascular function, body weight, mood, and cognition. Near-infrared spectroscopy is an ideal method to measure changes in oxygenated and deoxygenated hemoglobin (O2Hb and dHb) levels in th...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000266
更新日期:2014-11-12 00:00:00
abstract::Electroconvulsive therapy (ECT) is an appropriate clinical model to investigate blood flow during seizures. In this study cerebral blood flow velocity (CBFV) was measured during 40 ECTs in 10 patients by means of transcranial Doppler sonography. EEG was recorded continuously. Under general anesthesia, the pre-convulsi...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/00001756-199802160-00009
更新日期:1998-02-16 00:00:00
abstract::We investigated the detection of rare task-irrelevant changes in the lexical status of speech stimuli. Participants performed a nonlinguistic task on word and pseudoword stimuli that occurred, in separate conditions, rarely or frequently. Task performance for pseudowords was deteriorated relative to words, suggesting ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3282f0ea16
更新日期:2007-10-29 00:00:00
abstract::Voltage-gated ionic current and the response to quinine were studied on the four types of morphologically identified taste cells of the bullfrog fungiform papilla by whole-cell patch clamp recording with a Lucifer yellow-filled pipette. Dye-coupled type Ia cells (mucous cells) did not show voltage-activated currents. ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200109170-00040
更新日期:2001-09-17 00:00:00
abstract::Increasing evidence suggests a neurotransmitter role for NO in the mammalian CNS. We have now studied the behavioural and electrocortical (ECoG) profile of rats injected into the lateral cerebral ventricle (ICV) with L-arginine (L-arg), the endogenous donor of the guanidino group from which NO physiologically originat...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199105000-00014
更新日期:1991-05-01 00:00:00
abstract::With the purpose of elucidating the functional fields involved in the discrimination of visual form based either on luminance or binocular disparity cues, we used PET to measure changes in regional cerebral blood flow (rCBF) in ten volunteers while they performed visual discrimination tasks. The averaged standardized ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199411000-00039
更新日期:1994-11-21 00:00:00
abstract::Human neuroblastoma SH-SY5Y and small-cell lung carcinoma U1690 cells of neuroendocrine origin were exposed to morphine for 1 h, 3 h or 5 days. These treatments did not alter activities of AP-1, NF-kappa B and YY1 transcription factors in SH-SY5Y cells or NF-kappa B and YY1 in U1690 cells. Five-day morphine treatment,...
journal_title:Neuroreport
pub_type: 杂志文章
doi:
更新日期:1997-07-07 00:00:00
abstract::Net-like structures surrounding several types of neurones contain glycoconjugates which are detectable by lectins specific for N-acetylgalactosamine. Wisteria floribunda agglutinin (WFA) was introduced as a further marker for the visualization of such perineuronal nets, which were also revealed in regions of the rat b...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199210000-00012
更新日期:1992-10-01 00:00:00
abstract::In this functional MRI study, we investigated how the human brain activity represents tactile location information evoked by pressure stimulation on fingers. Using the searchlight multivoxel pattern analysis, we looked for local activity patterns that could be decoded into one of four stimulated finger locations. The ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000683
更新日期:2016-11-09 00:00:00
abstract::The putative neurotransmitter peptide CART has been suggested to be involved in the actions of psychostimulants. We analyzed the CART mRNA expression in mesolimbic brain areas of male and ovariectomized 17beta-estradiol- (30 microg) and vehicle-treated female rats. A gender difference was noted in the accumbens shell ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199911080-00034
更新日期:1999-11-08 00:00:00
abstract::The aim of the study was to investigate differences in the distribution of intranasal trigeminal receptors in humans using an electrophysiological measure of trigeminally induced activation, the negative mucosa potential. A total of 29 young, healthy volunteers participated, results were on the basis of data from 18 p...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000224764.61959.e8
更新日期:2006-09-18 00:00:00
abstract::The study aimed to investigate the time-course of electromagnetic field (EMF)-induced effects on human cognitive and behavioral performance and on tympanic temperature. Subjects were randomly assigned to two groups, exposed to a 902.40 MHz EMF before the testing session, or to the same signal during the data collectin...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00001756-200401190-00031
更新日期:2004-01-19 00:00:00