Abstract:
:The present paper reports how aluminium [Al(III)] at a concentration of 3.7 microM can activate the bovine erythrocytic enzyme acetylcholinesterase (AChE) by about 38% in vitro. This same activating effect was observed on AChE form human as well as from rat erythrocyte ghosts and murine neuroblastoma cells. The interaction between Al3+ and gamma-peripheral sites of the enzyme produces AChE structural modifications as evidenced by circular dichroism measurements. This may provide a molecular explanation of the raised enzymatic activity.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Zatta P,Zambenedetti P,Bruna V,Filippi Bdoi
10.1097/00001756-199409080-00023subject
Has Abstractpub_date
1994-09-08 00:00:00pages
1777-80issue
14eissn
0959-4965issn
1473-558Xjournal_volume
5pub_type
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