Activation of acetylcholinesterase by aluminium(III): the relevance of the metal species.

Abstract:

:The present paper reports how aluminium [Al(III)] at a concentration of 3.7 microM can activate the bovine erythrocytic enzyme acetylcholinesterase (AChE) by about 38% in vitro. This same activating effect was observed on AChE form human as well as from rat erythrocyte ghosts and murine neuroblastoma cells. The interaction between Al3+ and gamma-peripheral sites of the enzyme produces AChE structural modifications as evidenced by circular dichroism measurements. This may provide a molecular explanation of the raised enzymatic activity.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Zatta P,Zambenedetti P,Bruna V,Filippi B

doi

10.1097/00001756-199409080-00023

subject

Has Abstract

pub_date

1994-09-08 00:00:00

pages

1777-80

issue

14

eissn

0959-4965

issn

1473-558X

journal_volume

5

pub_type

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