Rat strain differences to fluoxetine in striatal Fos-like proteins.

Abstract:

:Humans afflicted with mood disorders respond differently to antidepressant drug therapy. Different responses to psychoactive drugs are also observed in rats, and specific strains exhibit substantial differences in gene expression following synaptic activity. We examined the effects of fluoxetine on the induction of Fos-like proteins in Long-Evans and Sprague-Dawley rat brains. Fluoxetine elicited a strong induction of Fos in the striatum of Long-Evans but not Sprague-Dawley rats following acute drug exposure. This effect was specific to fluoxetine as two highly selective serotonin reuptake inhibitors, HD-31 and HD-50, as well as treatment with fenfluramine failed to replicate the observed differences in Fos. These differences in Fos expression between rat strains may represent variability in post-receptor pathways that ultimately mediate the therapeutic actions of fluoxetine.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Horowitz JM,Hallas BH,Torres G

doi

10.1097/00001756-200212200-00018

subject

Has Abstract

pub_date

2002-12-20 00:00:00

pages

2463-7

issue

18

eissn

0959-4965

issn

1473-558X

journal_volume

13

pub_type

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