Evidence for a role for synaptophysin in expression of long-term potentiation in rat dentate gyrus.

Abstract:

:Maintenance of long-term potentiation in perforant path-granule cell synapses is accompanied by increased glutamate release. Here we investigate the role of synaptophysin in release and in expression of long-term potentiation in dentate gyrus. We report that long-term potentiation was accompanied by increased endogenous glutamate release and increased tyrosine phosphorylation of synaptophysin, but these changes were attenuated when long-term potentiation was inhibited by the tyrosine kinase inhibitor tyrphostin AG879 or by the NMDA antagonist D-aminophosphonovalerate. In vitro analysis revealed that KCl-induced glutamate release was abolished in synaptosomes prepared in the presence of antisynaptophysin. The data suggest a role for synaptophysin in release and indicate that activation of tyrosine kinase and synaptophysin phosphorylation contribute to long-term potentiation perhaps by modulating glutamate release.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Mullany PM,Lynch MA

doi

10.1097/00001756-199808030-00012

subject

Has Abstract

pub_date

1998-08-03 00:00:00

pages

2489-94

issue

11

eissn

0959-4965

issn

1473-558X

journal_volume

9

pub_type

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