Abstract:
:The alpha 2-macroglobulin receptor/low-density lipoprotein receptor-related protein (alpha 2-M-R/LRP) is a multifunctional receptor which has been implicated in lipoprotein metabolism, clearance of proteinase-proteinase inhibitor complexes and regulation of growth factor/cytokine metabolism. This receptor is abundantly present in numerous tissues and organs such as liver, lung, placenta and brain. In brain it is expressed in neurones but not in normal macroglia. Using immunocytochemistry and monoclonal antibodies against the large extracellular receptor subunit we have detected alpha 2-M-R/LRP on enzymatically isolated retinal Müller (glial) cells. This receptor may be involved in vital functions of Müller cells.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Birkenmeier G,Grosche J,Reichenbach Adoi
10.1097/00001756-199612200-00030subject
Has Abstractpub_date
1996-12-20 00:00:00pages
149-51issue
1eissn
0959-4965issn
1473-558Xjournal_volume
8pub_type
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