Immunocytochemical demonstration of alpha 2-M-R/LRP on Müller (glial) cells isolated from rabbit and human retina.

Abstract:

:The alpha 2-macroglobulin receptor/low-density lipoprotein receptor-related protein (alpha 2-M-R/LRP) is a multifunctional receptor which has been implicated in lipoprotein metabolism, clearance of proteinase-proteinase inhibitor complexes and regulation of growth factor/cytokine metabolism. This receptor is abundantly present in numerous tissues and organs such as liver, lung, placenta and brain. In brain it is expressed in neurones but not in normal macroglia. Using immunocytochemistry and monoclonal antibodies against the large extracellular receptor subunit we have detected alpha 2-M-R/LRP on enzymatically isolated retinal Müller (glial) cells. This receptor may be involved in vital functions of Müller cells.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Birkenmeier G,Grosche J,Reichenbach A

doi

10.1097/00001756-199612200-00030

subject

Has Abstract

pub_date

1996-12-20 00:00:00

pages

149-51

issue

1

eissn

0959-4965

issn

1473-558X

journal_volume

8

pub_type

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