Abstract:
:Calcitonin gene-related peptide (CGRP) and adrenomedullin are structurally similar neuropeptides acting as potent vasodilators of blood pressure and mediator of inflammation in skin. Revealing the expression pattern of their common receptor-Calcitonin gene-related peptide receptor (Calcrl) in their targeted cells is important to explain the functions of CGRP and adrenomedullin in skin. Our immunostaining results showed that Calcrl is enriched in hair follicles bulge stem cells and differentially expressed in basal stem cells of interfollicular epidermis. In addition, Calcrl expression in interfollicular epidermis is dependent on presence of nerve fibers. Long-term ablation of the murine cutaneous nerve leads to loss of Calcrl expression in interfollicular epidermis but not in hair follicle bulge stem cells. Our results demonstrate a tight interaction between neuronal components and epidermis, and indicates potential roles of Calcrl in epidermal stem cells.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Gong Y,Wei JP,Wang TH,Zhong HB,Liao XHdoi
10.1097/WNR.0000000000001497subject
Has Abstractpub_date
2020-08-05 00:00:00pages
814-818issue
11eissn
0959-4965issn
1473-558Xjournal_volume
31pub_type
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