Abstract:
:DJ-1, originally identified as an oncogene product, is involved in multiple processes, including cellular transformation, the oxidative stress response, and transcriptional regulation. We had previously found that DJ-1 was closely associated with the proliferation and differentiation of cultured neuronal stem cells. In this study, we further investigated the functions of DJ-1 to determine how adult neurogenesis was affected in the subgranular zones (SGZ), subventricular zone (SVZ), and olfactory bulb (OB), which are brain areas closely related to early nonmotor symptoms of Parkinson's disease, using a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of Parkinson's disease. The results showed that the numbers of 5-bromo-2-deoxyuridine-positive (BrdU) cells in the SGZ and SVZ of mice in the MPTP group were not significantly different from those in the saline controls, whereas the number of BrdU cells in the olfactory granule cell layer and glomerulus layer of the OB in the MPTP group changed markedly. We also found that DJ-1 was translocated into the nuclei of BrdU cells in the SGZ and SVZ, but not in the OB. This may indicate that the nuclear translocation of DJ-1 in the SGZ and SVZ protects adult neuronal stem cells from damage caused by MPTP so that the normal number is maintained, but is not involved in the protective mechanism in the OB.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Sun Y,Wang Y,Zhao X,Pu Xdoi
10.1097/WNR.0000000000000956subject
Has Abstractpub_date
2018-03-07 00:00:00pages
301-307issue
4eissn
0959-4965issn
1473-558Xjournal_volume
29pub_type
杂志文章相关文献
NEUROREPORT文献大全abstract::ErbBs are a family of receptors involved in the trophic maintenance of Schwann cells. Little is known about their expression changes during peripheral nerve regeneration. The aim of this study was thus to investigate variations in ErbBs after end-to-end and end-to-side nerve regeneration in the rat median nerve model....
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32831313ef
更新日期:2008-10-29 00:00:00
abstract::We investigated the effects of chemical hypoxia on the central pattern generator controlling swimming in stage 42 Xenopus laevis larvae. We recorded motoneuron activity from ventral roots of immobilized tadpoles and evoked swim episodes by brief electrical stimulation of the tail skin. In the presence of the metabolic...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32833e332d
更新日期:2010-10-06 00:00:00
abstract::To study the number cognition process, we recorded event-related potentials (ERPs) in 14 subjects when they were indicating whether a number pair was the same or not. The two numbers given in sequence were either the same (condition 1) or different (condition 2). After 270 ms following the onset of the second stimulus...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/00001756-200004270-00010
更新日期:2000-04-27 00:00:00
abstract::Decoding verbal and nonverbal emotional expressions is an important part of speech communication. Although various studies have tried to specify the brain regions that underlie different emotions conveyed in speech, few studies have aimed to specify the time course of emotional speech decoding. We used event-related p...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3282f454db
更新日期:2008-01-22 00:00:00
abstract::Menthol is known as an agonist for cold-sensitive transient receptor potential channels (TRPM8) and also as a direct modulator of GABA channels. We examined the effects of menthol on respiratory rhythm generation in the brainstem-spinal cord preparations isolated from newborn rats. Menthol decreased respiratory rhythm...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3283405bad
更新日期:2010-12-08 00:00:00
abstract::Inhibitory deficits are one of the predominant causes of cognitive aging. This study examined age-related changes in response inhibition. In this study, young and older participants performed a bimanual/bipedal response inhibition task while we measured their brain activity via functional near-infrared spectroscopy. P...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001516
更新日期:2020-10-07 00:00:00
abstract::We have studied the distribution of mGluR2/3 in the mouse superior colliculus (SC) with antibody immunocytochemistry and the effect of enucleation on this distribution. We also compared this labeling to that for calbindin D28K. Anti-mGluR2/3-immunoreactive (IR) cells formed distinctive laminar patterns within the lowe...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199904260-00034
更新日期:1999-04-26 00:00:00
abstract::Administration of either a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, MK-801 (dizocilpine), or a muscarinic antagonist, scopolamine, produces dose-related impairments in performance of a visual recognition memory task, delayed non-matching to sample (DNMS) with lists of 20 symbols, in rhesus monk...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199601310-00045
更新日期:1996-01-31 00:00:00
abstract::We examined the effect of long-term potentiation (LTP) on paired-pulse responses across varied stimulus intensities and interstimulus intervals (ISIs), at ascending synapses from the intermediate and ventral hippocampus to the medial prefrontal cortex in urethane-anesthetized rats. LTP significantly shifted the median...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3283344949
更新日期:2010-01-06 00:00:00
abstract::To examine the relationship between plasma lipoproteins and apolipoproteins in men with convictions for violent offences, blood was obtained from 15 men with a history of violence who were serving prison sentences for violent offences, and 25 age-matched male controls from the staff of the Argyll and Bute Psychiatric ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199306000-00039
更新日期:1993-06-01 00:00:00
abstract::The function of the lateral part of the human cerebellum was investigated through cerebro-cerebellar functional connectivity. We propose a laterality index method to reveal a functional and possibly anatomical pathway between the cerebral cortex and the cerebellum. The brain activity involved in learning a visually-gu...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199902050-00022
更新日期:1999-02-05 00:00:00
abstract::Inherited retinal degenerations such as retinitis pigmentosa (RP) are characterized by progressive loss of photoreceptors, apparently by apoptosis, and our recent report of increased secreted Frizzled-related protein-2 (SFRP2) in RP retinas suggests altered Wnt signalling may be a component of the degenerative process...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200012180-00012
更新日期:2000-12-18 00:00:00
abstract::Multiple signal classification is an alternative to the traditional dipole fitting source analysis methods. Our aim was to assess the clinical usefulness of this algorithm and to compare the localization of the epileptiform electroencephalography discharges with the regions of altered cerebral blood flow in 10 patient...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000230517.93714.f6
更新日期:2006-08-21 00:00:00
abstract::One problem in motor control concerns the mechanism whereby the central nervous system translates the motor cortical command encoded in cell activity into a coordinated contraction of limb muscles to generate a desired motor output. This problem is closely related to the design of adaptive systems that transform neuro...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199611040-00038
更新日期:1996-11-04 00:00:00
abstract::Subcortical visual inputs to motion-selective cortex in primates survive after damage to the primary visual cortex (area 17/V1). Activation of human motion cortex was examined using scalp electrodes in a V1-damaged hemianope. Blind field motion-onset visual evoked potentials (VEPs) shared many of the characteristics a...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199911260-00024
更新日期:1999-11-26 00:00:00
abstract::Elevations of cytosolic free Ca2+ concentration ([Ca2+]i) induced by addition of ATP have been compared in rat dorsal horn neurones in slices and after their isolation. ATP application induced in neurones in situ a rise of [Ca2+]i by 201 +/- 12 nM. In Ca2+-free external solution the rise was 156 +/- 14 nM (n = 45 of 7...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200111160-00026
更新日期:2001-11-16 00:00:00
abstract::This study investigated the functional neuroanatomy involved in retrieval of structured versus unstructured verbal information. We compared cerebral blood flow using PET with the [15O]water method while subjects engaged in recall of novel and practised narratives and lists of unrelated words. Left orbital frontal cort...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/00001756-199709290-00017
更新日期:1997-09-29 00:00:00
abstract::Melatonin has been shown to exert potent antinociception but the sites and mechanisms of action underlying this effect have not yet been clarified. The effect of melatonin on spinal cord nociceptive transmission was studied in rats by assessing wid-up activity in a C-fiber reflex responses paradigm evoked by repetitiv...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200201210-00021
更新日期:2002-01-21 00:00:00
abstract::Decisions made on the basis of risk often require rapid evaluation of feedback before follow-up actions and feedback-related negativity in brain potential is sensitive to the poor outcome. The current study investigated the effects of feedback from one's own decision (Experiment 1) and feedback from observing others' ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000452
更新日期:2015-11-11 00:00:00
abstract::The present study aims to study sequential alterations occurring in both dopaminergic neurons and microglia in substantia nigra (SN) following intrastriatal injection of 1-methyl-4-phenylpridium ion (MPP+) in rats. Heme oxygenase-1 (HO-1), a marker of oxidative stress, first appeared in dopaminergic neurons in SN at 1...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200404290-00021
更新日期:2004-04-29 00:00:00
abstract::In this study it was shown that in adults, the frequency characteristics of EEG preceding stimuli that were followed by incorrect responses were different from the characteristics of EEG preceding stimuli that were followed by correct responses. In the recording during three different tasks that explore different neur...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200008210-00012
更新日期:2000-08-21 00:00:00
abstract::Is functional neuroimaging a royal way to understand brain function or is it a new phrenology without an exact understanding what we measure? After two decades of imaging revolution, more and more authors ask this question. Brain functions are multidimensional, which can be approached from the point of (1) behavioural...
journal_title:Neuroreport
pub_type: 杂志文章,评审
doi:10.1097/00001756-200306110-00001
更新日期:2003-06-11 00:00:00
abstract::Antagonist action at dopamine D2 receptors appears to explain many, but not all of the effects of antipsychotic drugs. Because of the interactions of dopamine with glutamate, and the implication of the latter in the etiology of schizophrenia, possible effects of antipsychotic drugs on glutamate receptors were assessed...
journal_title:Neuroreport
pub_type: 杂志文章
doi:
更新日期:1995-12-15 00:00:00
abstract::Interleukin-2 and its receptors are present in hippocampal structures, particularly the pyramidal cell layer. In the present study, we examined the interaction between recombinant human interleukin-2 (rhIL-2) and the voltage-dependent calcium (Ca2+) current using the whole-cell patch-clamp technique. RhIL-2 depressed ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199305000-00030
更新日期:1993-05-01 00:00:00
abstract::We investigated the effects of 2,2,2-trichloroethanol (TCE), the active metabolite of chloral hydrate, on large-conductance calcium-activated K+ channels (BKCa channels) of dorsal root ganglion (DRG) neurones. In outside-out patches, 2 and 5 mM TCE increased the open probability of BKCa channels to 1.7-fold and 2.8-fo...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200205070-00023
更新日期:2002-05-07 00:00:00
abstract::Autism is a neurodevelopmental disorder characterized by preserved visual abilities as well as a special profile for visual cognition. We examined the visual cortex of high-ability individuals with autism in order to assess whether the presence of abnormalities at the primary sensory level in autism could be the basis...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200402090-00011
更新日期:2004-02-09 00:00:00
abstract::To assess the effect of genetic factors on sporadic Parkinson disease, we performed a case-control study of a variant (G2385R) in Leucine-Rich Repeat kinase 2 among the Japanese population. The G2385R (c.7153G>A) variant was reported as a risk factor for sporadic Parkinson disease in the Chinese population from Taiwan...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32801254b6
更新日期:2007-02-12 00:00:00
abstract::The current study aimed to investigate the altered cerebellar-cerebral functional connectivity (FC) induced by radiotherapy to nasopharyngeal carcinoma (NPC) patients. Twenty-four NPC patients without treatment, and 35 NPC patients receiving radiotherapy underwent functional MRI scanning. Montreal cognitive assessment...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000813
更新日期:2017-08-16 00:00:00
abstract::Canine degenerative myelopathy (DM) is a fatal neurodegenerative disorder prevalent in the canine population. It may represent a unique, naturally occurring disease model for human amyotrophic lateral sclerosis (ALS) because of similar clinical signs and association with superoxide dismutase 1 gene (SOD1) mutations. M...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001151
更新日期:2019-01-02 00:00:00
abstract::Cyclin-dependent kinases (CDK) mediate the cell division cycle during G1 phase and CDK inhibitors negatively regulate the cell cycle. We investigated expression of the CDK inhibitor p27Kip1 and the effects of PI-3K/Akt on proliferation of progenitors in the subventricular zone of adult rat. Western blots and immunosta...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000135693.81613.cc
更新日期:2004-08-06 00:00:00