Abstract:
:The present study aims to study sequential alterations occurring in both dopaminergic neurons and microglia in substantia nigra (SN) following intrastriatal injection of 1-methyl-4-phenylpridium ion (MPP+) in rats. Heme oxygenase-1 (HO-1), a marker of oxidative stress, first appeared in dopaminergic neurons in SN at 1 day post-lesion. Subsequently, microglia in SN exhibited morphological changes indicative of activation. At 7 days post-lesion, those findings increased severity and 7a significant reduction in the number of dopaminergic neurons was observed. The present finding suggests that extensive oxidative stress and secondary-induced neuroinflammation play a relevant role in MPP(+)-induced retrograde dopaminergic neuron degeneration. We hope that this model will be useful in developing a disease modifying therapy of Parkinson's disease.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Miwa H,Kubo T,Morita S,Nakanishi I,Kondo Tdoi
10.1097/00001756-200404290-00021subject
Has Abstractpub_date
2004-04-29 00:00:00pages
1039-44issue
6eissn
0959-4965issn
1473-558Xpii
00001756-200404290-00021journal_volume
15pub_type
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