Abstract:
:The whole-cell patch-clamp technique was employed to investigate the development of voltage-gated currents in cultured newt retinal pigment epithelial (RPE) cells. Freshly dissociated RPE cells were inexcitable and mainly exhibited a voltage-gated outward K+ current. Within a few days in culture RPE cells began to flatten and gradually became less pigmented. During subsequent time in culture the cells proliferated and formed monolayer colonies containing depigmented cells. About 36% cells (15/42) examined between 6 and 21 days in culture developed the voltage-gated inward currents. In two depigmented cells cultured for more than 17 days, the sustained inward Ca2+ current was developed. The result suggests that RPE cells develop the voltage-gated inward currents responsible for retinal neurones with time in culture.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Sakai H,Saito Tdoi
10.1097/00001756-199404000-00020subject
Has Abstractpub_date
1994-04-14 00:00:00pages
933-6issue
8eissn
0959-4965issn
1473-558Xjournal_volume
5pub_type
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