Regulation of serotonin release in the Syrian hamster intergeniculate leaflet region.

Abstract:

:In mammals, the thalamic intergeniculate leaflet (IGL) conveys behavioral (non-photic) phase-resetting information to the circadian clock of the suprachiasmatic nucleus. Here we report a 24 h fluctuation in in vivo serotonin release in the hamster IGL region, peaking at night. Novel wheel exposure at midday, a stimulus that can reset circadian phase, activates the release of serotonin in the IGL region. In addition, electrical stimulation of the dorsal raphe nucleus acutely increases serotonin release the IGL region, confirming a functional serotonergic projection from this nucleus to the IGL. Collectively, these findings suggest that behavioral and/or circadian changes in dorsal raphe nuclear activity could modulate serotonin-mediated activities of the IGL.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Grossman GH,Farnbauch L,Glass JD

doi

10.1097/00001756-200401190-00021

subject

Has Abstract

pub_date

2004-01-19 00:00:00

pages

103-6

issue

1

eissn

0959-4965

issn

1473-558X

journal_volume

15

pub_type

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