Abstract:
:Calcium increases induced by single action potentials in rat visual cortex layer II/III pyramidal neurons were shown to be augmented by muscarinic acetylcholine receptor (mAchR) stimulation. This augmentation was drastically reduced by intracellular injection of heparin but not ruthenium red, therefore involving inositol-1,4,5-trisphosphate (IP3)-sensitive rather than ryanodine-sensitive calcium stores. Only the calcium increase induced by the second or later spike of a spike train, but not that induced by the first spike, was augmented, indicating the requirement of both spike-induced calcium increase and mAchR activation. The calcium store depletor thapsigargin abolished this augmentation use-dependently. These findings suggest a neocortical occurrence of calcium-induced calcium release from IP3-sensitive calcium stores that have been sensitized beforehand by IP3 through mAchR-mediated mechanisms.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Yamamoto K,Hashimoto K,Isomura Y,Shimohama S,Kato Ndoi
10.1097/00001756-200002280-00022subject
Has Abstractpub_date
2000-02-28 00:00:00pages
535-9issue
3eissn
0959-4965issn
1473-558Xjournal_volume
11pub_type
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