Abeta levels in serum, CSF and brain, and cognitive deficits in APP + PS1 transgenic mice.

abstract：:Previous studies have shown that spatial memory retention is affected by the metabotropic glutamate receptor (mGluR) influencing agents (R,S)-alpha-methyl-4-carboxyphenylglycine (MCPG) and trans-azetidine-2,4-dicarboxylic acid (tADA). In the present investigation we examined whether the mGluR antagonist MCPG (20 mM an...

journal_title：Neuroreport

authors： Wetzel W,Wagner T,Reymann KG,Riedel G

更新日期：1995-11-27 00:00:00

abstract：:This study examined the potential of embryonic stem cell-derived neurons as transplants for cell therapy for the primary loss of spiral ganglion neurons. To assess the ability of embryonic stem cell-derived neurons for innervation into auditory epithelia, they were cocultured with auditory epithelium explants of mice ...

journal_title：Neuroreport

authors： Matsumoto M,Nakagawa T,Higashi T,Kim TS,Kojima K,Kita T,Sakamoto T,Ito J

更新日期：2005-05-31 00:00:00

abstract：:We have established an in-vitro coculture-system of adult rat retina with fetal midbrain explants to examine whether regenerating central nervous system axons are still able to recognize appropriate target neurons. Our results show that the retinal ganglion cell axons regenerate their axons and reinnervate the retino-...

journal_title：Neuroreport

authors： Bähr M,Eschweiler GW

更新日期：1991-10-01 00:00:00

abstract：:Methamphetamine (METH) is a drug of abuse used for its stimulant effects. Its neurotoxicity is very variable, and is increased by a number of factors, including crowded conditions and increased ambient temperature. The effects of such factors are increasingly important, with the widespread use of these stimulants at n...

journal_title：Neuroreport

authors： Morton AJ,Hickey MA,Dean LC

更新日期：2001-10-29 00:00:00

abstract：:The effects of copper on voltage-gated A-type potassium currents were investigated in acutely dissociated rat hippocampal CA1 neurons using the whole-cell patch-clamp technique. Extracellular application of various concentrations of copper (1-1000 microM) reversibly reduced the amplitude of voltage-gated A-type potass...

journal_title：Neuroreport

authors： Niu ZD,Yu K,Gu Y,Wang M,She JQ,Chen WH,Ruan DY

更新日期：2005-09-28 00:00:00

abstract：:The present paper reports how aluminium [Al(III)] at a concentration of 3.7 microM can activate the bovine erythrocytic enzyme acetylcholinesterase (AChE) by about 38% in vitro. This same activating effect was observed on AChE form human as well as from rat erythrocyte ghosts and murine neuroblastoma cells. The intera...

journal_title：Neuroreport

authors： Zatta P,Zambenedetti P,Bruna V,Filippi B

更新日期：1994-09-08 00:00:00

abstract：:GLYX-13 (threonine-proline-proline-threonine-amide) is an amidated di-pyrrolidine that acts as a functional partial agonist at the glycine site on N-methyl-D-aspartate glutamate receptors (NMDARs). GLYX-13 can both increase NMDAR conductance at NR2B-containing receptors, and reduce conductance of non-NR2B-containing r...

journal_title：Neuroreport

authors： Stanton PK,Potter PE,Aguilar J,Decandia M,Moskal JR

更新日期：2009-08-26 00:00:00

abstract：:The precise role of prostaglandin-D-synthase (beta-trace protein), the major constituent of cerebrospinal fluid, is unclear. In the present study, a sensitive and highly specific fluoroimmunoassay was developed. The measurement of the enzyme levels in rat CSF revealed a developmental change in the CSF levels with the ...

journal_title：Neuroreport

authors： Kabeya K,Ishikawa K,Katakai K,Watanabe M,Ohe Y,Wakabayashi K,Mori M

更新日期：1998-03-30 00:00:00

abstract：:Alopecia areata (AA) is a dermatosis involving the sudden occurrence of bald patches on the scalp. Although the aetiology is unknown, experimental data indicate that cutaneous microcirculation plays an important role. The skin is richly innervated by neuropeptidergic sensory nerves that help regulate microvascular cir...

journal_title：Neuroreport

authors： Rossi R,Del Bianco E,Isolani D,Baccari MC,Cappugi P

更新日期：1997-03-24 00:00:00

abstract：:Whole bee venom (WBV)-induced pain model has been reported to be very useful for the study of pain. However, the major constituent responsible for the production of pain by WBV is not apparent. Intraplantar injection of WBV and melittin dramatically reduced mechanical threshold, and increased flinchings and paw thickn...

journal_title：Neuroreport

authors： Shin HK,Kim JH

更新日期：2004-08-06 00:00:00

abstract：:Peripheral nerve injury therapy in the clinic remains less than satisfactory. The gold standard of treatment for long peripheral nerve defects is autologous nerve grafts; however, numerous clinical complications are associated with this treatment. As tissue engineering has developed, tissue-engineered nerve grafts (TE...

journal_title：Neuroreport

authors： Yan L,Yao Z,Lin T,Zhu Q,Qi J,Gu L,Fang J,Zhou X,Liu X

更新日期：2017-10-18 00:00:00

abstract：:The study was conducted to investigate the effect of serotonin depletion on nitric oxide-induced meningeal vascular response and cerebrovascular nociception. Nitroglycerin was infused i.v. to control and serotonin-depleted rats. Pial circulation was monitored by intravital fluorescent videomicroscopy and Fos immunorea...

journal_title：Neuroreport

authors： Srikiatkhachorn A,Anuntasethakul T,Phansuwan-Pujito P,Patumraj S,Kasantikul V

更新日期：2001-04-17 00:00:00

abstract：:To investigate the phonological influences on the lexicosemantic process with a strong orthographic constraint, we used kanji (morphogram) homophone words and measured, using magnetoencephalography, the neural activities during the silent reading of prime-target pairs. The primes were phonologically the same as or dif...

journal_title：Neuroreport

authors： Wei Q,Ihara A,Hayakawa T,Murata T,Matsumoto E,Fujimaki N

更新日期：2007-11-19 00:00:00

abstract：:The present study examined the effects of cocaine-regulated and amphetamine-regulated transcript peptide (CARTp) fragment 55-102, on N-methyl-D-aspartate (NMDA)-mediated nociceptive transmission in vivo and in vitro. In-vivo experiments were conducted in Sprague-Dawley rats to evaluate the effects of CARTp on thermal ...

journal_title：Neuroreport

authors： Hsun Lin H,Chiu HY,Lai CC

更新日期：2005-02-28 00:00:00

abstract：:Neuromagnetic signals evoked by synthesized syllables (/bae/ and /gae/) were recorded over the left auditory cortex of healthy humans. The fundamental frequencies of the syllables varied as if the same speaker had pronounced them at 16 different pitches. Specific mismatch responses to infrequent syllables among freque...

journal_title：Neuroreport

authors： Aulanko R,Hari R,Lounasmaa OV,Näätänen R,Sams M

更新日期：1993-09-30 00:00:00

abstract：:Functional neuroimaging studies of handedness have traditionally focused on exploring regionally activated discrepancies, yet little is known regarding the effect of handedness on functional connections of brain regions. Here, we reported the relationship between cerebellar functional connectivity patterns and handedn...

journal_title：Neuroreport

authors： He Y,Zang Y,Jiang T,Gong G,Xie S,Xiao J

更新日期：2006-01-23 00:00:00

abstract：:The environment in which cocaine is experienced becomes associated with the effects of the drug and can then elicit cocaine craving. This study examined whether the hippocampus is involved in such associations using the conditioned place preference model. Rats received bilateral lesions of the dorsal or ventral hippoc...

journal_title：Neuroreport

authors： Meyers RA,Zavala AR,Neisewander JL

更新日期：2003-11-14 00:00:00

abstract：:Anti-leucine-rich glioma inactivated 1 (anti-LGI1) encephalitis is one of the most frequently encountered forms of autoimmune encephalitis. Many patients with anti-LGI1 encephalitis develop permanent hippocampal neuron loss and chronic neuropsychiatric symptoms, suggesting that LGI antibodies (Ab) might have a neuroto...

journal_title：Neuroreport

authors： Ayşit-Altuncu N,Ulusoy C,Öztürk G,Tüzün E

更新日期：2018-08-01 00:00:00

abstract：:It has been suggested that high levels of prenatal testosterone exposure are implied in the aetiology of dyslexia and its frequently co-occurring sensory problems. This study examined 2D : 4D digit ratio (a marker of fetal testosterone exposure) in dyslexic and normal reading children. No group differences in 2D : 4D ...

journal_title：Neuroreport

authors： Boets B,De Smedt B,Wouters J,Lemay K,Ghesquière P

更新日期：2007-09-17 00:00:00

abstract：:We demonstrate the use of magnetic resonance imaging (MRI) for detection of neurotransmitter stimulation using the dopamine transporter ligands amphetamine and CFT (2beta-carbomethoxy-3beta-(4-fluorophenyl)tropane) as pharmacological challenges. We demonstrate that the unilateral loss of a hemodynamic response to eith...

journal_title：Neuroreport

authors： Chen YI,Brownell AL,Galpern W,Isacson O,Bogdanov M,Beal MF,Livni E,Rosen BR,Jenkins BG

更新日期：1999-09-29 00:00:00

abstract：:The effect of temporal interference of physiological signals on time-lag effective connectivity, derived from a functional network connectivity tool box (FNC), was examined by a blood-oxygen-level-dependent functional MRI study of action. The known effect of physiological signals on time-lag FNC was verified by (a) co...

journal_title：Neuroreport

authors： Huang JM,Cheng CM,Chou CC,Chen YC,Hsu PY,Yeh TC

更新日期：2013-01-09 00:00:00

abstract：:Regional brain activity associated with intentional and incidental memory retrieval was studied with PET. Previously studied and new words were presented in either an intentional or an incidental memory task. Type of task was crossed with an encoding manipulation ('deep' vs 'shallow') which varied the probability that...

journal_title：Neuroreport

authors： Rugg MD,Fletcher PC,Frith CD,Frackowiak RS,Dolan RJ

更新日期：1997-03-24 00:00:00

abstract：:The present investigation provide evidences from a non-human primate model that naturally occurring menopause predicts a prominent signature of age-related cognitive decline. Young and aged rhesus monkeys were tested on a delayed response (DR) task known to the sensitive to aging, and reproductive status was evaluated...

journal_title：Neuroreport

authors： Roberts JA,Gilardi KV,Lasley B,Rapp PR

更新日期：1997-05-27 00:00:00

abstract：:The distribution of the enzyme NADPH diaphorase in the region of the periaqueductal gray (PAG) was studied in the rat, rabbit, cat, monkey and human. In each species, the enzyme labelled a small band of neurones located below the level of the aqueduct and directly above the supraoculomotor gray in the middle of the an...

journal_title：Neuroreport

authors： Carrive P,Paxinos G

更新日期：1994-11-21 00:00:00

abstract：:The NMa and NMb isoforms of cytochrome P450 enzymes are expressed in three nasal chemosensory organs: the olfactory, septal and vomeronasal mucosae. The NMa isoform is widely distributed throughout the nasal mucosa whereas the NMb isoform is present primarily in the chemosensory mucosae. The localization of cytochrome...

journal_title：Neuroreport

authors： Chen Y,Getchell ML,Ding X,Getchell TV

更新日期：1992-09-01 00:00:00

abstract：:Alzheimer disease (AD) patients show increased plasma levels of homocysteine, whose conversion to methionine is catalyzed by methionine synthase (MS). Although altered MS activity may result from the MS A2756G polymorphism, the latter's possible associ-ation with AD remains unexplored. To assess whether the MS A2756G ...

journal_title：Neuroreport

authors： Beyer K,Lao JI,Latorre P,Riutort N,Matute B,Fernández-Figueras MT,Mate JL,Ariza A

更新日期：2003-07-18 00:00:00

abstract：:Neural cells have distinct responses to CNS injury; however, neural progenitor response to CNS injury is not yet documented. Stab injury combined with injection of bromodeoxyuridine (BrdU), a thymidine analog, into adult rat cortex above the lateral ventricle for 10 min resulted in activated microglia/macrophage infil...

journal_title：Neuroreport

authors： Tzeng SF,Wu JP

更新日期：1999-08-02 00:00:00

abstract：:This study describes gamma-imaging of the secondary tumors from the transplanted human fetal striatum neural stem cells-derived primary tumor cells in nude mice. The subcutaneous primary tumors were detected to express integrin alphavbeta3, and the corresponding cells were isolated and enriched in vitro, then transpla...

journal_title：Neuroreport

authors： He Q,Liu Z,Jia B,Li X,Shi J,Zhang J,Lan F,Yang Z,Liu Y,Shen L,Wang F

更新日期：2008-07-02 00:00:00

abstract：:The present study examined in urethane-chloralose anaesthetized rats whether N-methyl-D-aspartate (NMDA) is involved in the depressant effect of flupirtine on the monosynaptic Hoffmann (H)-reflex recorded from plantar foot muscles and on polysynaptic flexor reflexes recorded from tibialis muscle. Intrathecal administr...

journal_title：Neuroreport

authors： Schwarz M,Block F,Pergande G

更新日期：1994-10-03 00:00:00

abstract：:To investigate the origin of high-frequency somatosensory evoked potential (SEP) components, we recorded median nerve SEPs from the scalp and the depth in six monkeys. Laminar field potentials were analyzed in area 3b (N10; corresponding to human N20) and area 1 (P12; corresponding to human P25). After digital filteri...

journal_title：Neuroreport

authors： Shimazu H,Kaji R,Tsujimoto T,Kohara N,Ikeda A,Kimura J,Shibasaki H

更新日期：2000-08-21 00:00:00