Abstract:
:Previous studies have shown that spatial memory retention is affected by the metabotropic glutamate receptor (mGluR) influencing agents (R,S)-alpha-methyl-4-carboxyphenylglycine (MCPG) and trans-azetidine-2,4-dicarboxylic acid (tADA). In the present investigation we examined whether the mGluR antagonist MCPG (20 mM and 200 mM/5 microliters, respectively) and the agonist tADA (20 mM/5 microliters) have other behavioural effects using the open field test on two successive days. Only minor effects of MCPG (decrease of crossings during the 1st min on day 1) and tADA (increase of rearings on both days) were found. These results suggest that memory influencing doses of MCPG and tADA have no or only little behavioural effects in the open field situation.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Wetzel W,Wagner T,Reymann KG,Riedel Gdoi
10.1097/00001756-199511270-00027subject
Has Abstractpub_date
1995-11-27 00:00:00pages
2389-93issue
17eissn
0959-4965issn
1473-558Xjournal_volume
6pub_type
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