Co-localization of PKCepsilon with various GABA(A) receptor subunits in the mouse limbic system.

Abstract:

:The distribution of PKCepsilon and its co-localization with various GABA(A) receptor subunits within limbic structures of the mouse brain was examined by fluorescence immunohistochemistry. Levels of PKCepsilon immunoreactivity were highest in the cingulate cortex and dentate gyrus, moderate in the nucleus accumbens, and lowest in the prelimbic cortex and basolateral amygdala. Co-localization of PKCepsilon immunoreactivity with the GABA(A) receptor alpha1, beta 2/3, and gamma2 subunits varied by subunit and brain region examined, with the majority of co-localization occuring in the dentate gyrus, nucleus accumbens and basolateral amygdala. These results demonstrate that PKCepsilon may interact with GABA(A) receptors in a subunit- and region-specific manner, and provide a potential anatomical basis for recent behavioral and biochemical evidence that PKCepsilon modulates GABA(A) receptor function.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Olive MF,Hodge CW

doi

10.1097/00001756-200003200-00006

subject

Has Abstract

pub_date

2000-03-20 00:00:00

pages

683-7

issue

4

eissn

0959-4965

issn

1473-558X

journal_volume

11

pub_type

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