Object memory in young and aged mice after sevoflurane anaesthesia.

Abstract:

:Learning and memory are cognitive functions commonly impaired after surgery, especially in elderly patients. Our aim was to evaluate the effect of sevoflurane anaesthesia on episodic-like memory in young and aged wild-type mice and mice with altered nicotinic cholinergic neurotransmission (beta2KO). Mice learned objects before randomization to control, anaesthesia or sham groups. Anaesthesia was maintained at 2.6% sevoflurane for 2 h, starting immediately after training. Object memory testing was performed after 24 h, when one familiar object was replaced by a nonfamiliar object. While nonanaesthetized mice showed memory retention of the familiar object, anaesthetized wild-type and beta2KO mice showed impaired memory. Sevoflurane anaesthesia thus causes memory impairment in mice regardless of beta2 receptor-mediated nicotinic cholinergic neurotransmission.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Wiklund A,Granon S,Faure P,Sundman E,Changeux JP,Eriksson LI

doi

10.1097/WNR.0b013e328330cd2b

subject

Has Abstract

pub_date

2009-10-28 00:00:00

pages

1419-23

issue

16

eissn

0959-4965

issn

1473-558X

journal_volume

20

pub_type

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