Abstract:
:Learning and memory are cognitive functions commonly impaired after surgery, especially in elderly patients. Our aim was to evaluate the effect of sevoflurane anaesthesia on episodic-like memory in young and aged wild-type mice and mice with altered nicotinic cholinergic neurotransmission (beta2KO). Mice learned objects before randomization to control, anaesthesia or sham groups. Anaesthesia was maintained at 2.6% sevoflurane for 2 h, starting immediately after training. Object memory testing was performed after 24 h, when one familiar object was replaced by a nonfamiliar object. While nonanaesthetized mice showed memory retention of the familiar object, anaesthetized wild-type and beta2KO mice showed impaired memory. Sevoflurane anaesthesia thus causes memory impairment in mice regardless of beta2 receptor-mediated nicotinic cholinergic neurotransmission.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Wiklund A,Granon S,Faure P,Sundman E,Changeux JP,Eriksson LIdoi
10.1097/WNR.0b013e328330cd2bsubject
Has Abstractpub_date
2009-10-28 00:00:00pages
1419-23issue
16eissn
0959-4965issn
1473-558Xjournal_volume
20pub_type
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