Cue-induced renewal of heroin place preference: involvement of the basolateral amygdala.

Abstract:

:It is well established that re-exposure to a context paired with the effects of drugs of abuse can renew extinguished drug seeking behavior. A context, however, typically includes several stimuli, which may differ in their ability to control drug-oriented behaviors. Hence, the primary objective of this study was to assess whether a heroin-induced place preference could be recovered by re-exposure to a contextual stimulus that was part of the conditioning context before extinction. The second objective was to explore the role of the basolateral nucleus of the amygdala (BLA) in this conditioned effect. Male Sprague-Dawley rats were injected with 3 mg/kg heroin and confined in a compartment that was distinguished by a variety of contextual stimuli, including a ceramic floor tile. During extinction, the floor stimulus was removed, and it was reintroduced for a drug-free test of preference. A control experiment evaluated the unconditioned preference for the floor stimulus. It was found that reintroduction of the floor stimulus caused the recovery of heroin place preference. This effect was not observed in rats infused in the BLA with muscimol (0.03 nmol) and baclofen (0.3 nmol) just prior to the test. These data suggest that an extinguished heroin place preference can be renewed by a contextual tactual stimulus that was part of the conditioning context, and that this process requires an intact BLA.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Cummins E,Boughner E,Leri F

doi

10.1097/WNR.0000000000000084

subject

Has Abstract

pub_date

2014-03-26 00:00:00

pages

297-302

issue

5

eissn

0959-4965

issn

1473-558X

journal_volume

25

pub_type

杂志文章
  • Glucagon-like peptide-1 modulates neuronal activity in the rat's hippocampus.

    abstract::In order to assess effects of glucagon-like peptide-1 (GLP-1) in the brain excluding the hypothalamus, the effects of GLP-1 (7-36) amide, a naturally produced active fragment, on the electroencephalogram and hippocampal single unit activities of anesthetized male Wistar rats were examined. I.c.v. injection of GLP-1 (7...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199906030-00004

    authors: Oka JI,Goto N,Kameyama T

    更新日期:1999-06-03 00:00:00

  • In vivo studies with [125I]5-I-A-85380, a nicotinic acetylcholine receptor radioligand.

    abstract::5-[125I]iodo-3-(2(S)-azetidinylmethoxy)pyridine ([125I]5-I-A-85380) was evaluated in the mouse as a potential in vivo imaging ligand for central nicotinic acetylcholine receptors (nAChRs). After i.v. administration of [125I]5-I-A-85380, peak brain levels of radioactivity were measured within 1 h and declined slowly ov...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199807130-00030

    authors: Vaupel DB,Mukhin AG,Kimes AS,Horti AG,Koren AO,London ED

    更新日期:1998-07-13 00:00:00

  • NMDA receptor blockade reverses motor response alterations induced by levodopa.

    abstract::Motor fluctuations that ultimately complicate the response of most parkinsonian patients to levodopa therapy might represent a form of behavioral or neuronal plasticity. Since various forms of neuronal plasticity appear to be mediated by glutamate transmission through the N-methyl-D-aspartate (NMDA) receptor, the effe...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199412000-00045

    authors: Engber TM,Papa SM,Boldry RC,Chase TN

    更新日期:1994-12-20 00:00:00

  • Aggressive behaviour in transgenic mice expressing APP is alleviated by serotonergic drugs.

    abstract::Transgenic mouse strains were generated that overexpress human APP or clinical mutants of APP. All transgenic mouse strains that over-express APP displayed essentially the same phenotype of disturbed behaviour, differential glutamatergic responses, deficits in maintenance of long-term potentiation and premature death,...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199811160-00004

    authors: Moechars D,Gilis M,Kuipéri C,Laenen I,Van Leuven F

    更新日期:1998-11-16 00:00:00

  • Disabling Gβγ-SNAP-25 interaction in gene-targeted mice results in enhancement of long-term potentiation at Schaffer collateral-CA1 synapses in the hippocampus.

    abstract::Three SNARE proteins, SNAP-25, syntaxin 1A, and VAMP2 or synaptobrevin 2, constitute the minimal functional machinery needed for the regulated secretion of neurotransmitters. Dynamic changes in the regulated release of neurotransmitters are associated with the induction of long-term plasticity at central synapses. In-...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000001258

    authors: Irfan M,Zurawski Z,Hamm HE,Bark C,Stanton PK

    更新日期:2019-07-03 00:00:00

  • NMDA-stimulated expression of BDNF mRNA in cultured cerebellar granule neurones.

    abstract::The brain-derived neurotrophic factor (BDNF) affects the developing cerebellar granule cells. Exposure of 9-11-day-old primary cultures of rat cerebellar granule neurones for 3 h to a more depolarizing medium (additional 15-30 mM KCl) stimulated the release of glutamate and increased the BDNF mRNAs levels. This BDNF a...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:

    authors: Favaron M,Manev RM,Rimland JM,Candeo P,Beccaro M,Manev H

    更新日期:1993-09-03 00:00:00

  • Interference and facilitation in overt speech production investigated with event-related potentials.

    abstract::We report an event-related potential study investigating the neural basis of interference and facilitation in the picture-word interference paradigm with immediate overt naming. We used the high temporal resolution of the electrophysiological response to dissociate general and specific interference processes, by compa...

    journal_title:Neuroreport

    pub_type: 临床试验,杂志文章

    doi:10.1097/WNR.0b013e328309ecd1

    authors: Hirschfeld G,Jansma B,Bölte J,Zwitserlood P

    更新日期:2008-08-06 00:00:00

  • Ontogeny of two different benzodiazepine binding sites in the chick optic lobe.

    abstract::The developmental time-course of type I and type II benzodiazepine receptors in the chick optic lobe was determined using a triazolopyridazine, CL 218872. At embryonic day 13 most of the binding sites corresponded to type II (98.23%), while type I represented only a minor proportion (1.77%). During development there w...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199510010-00015

    authors: Gravielle MC,de Plazas SF

    更新日期:1995-10-23 00:00:00

  • The role of precisely matching fascicles in the quick recovery of nerve function in long peripheral nerve defects.

    abstract::Peripheral nerve injury therapy in the clinic remains less than satisfactory. The gold standard of treatment for long peripheral nerve defects is autologous nerve grafts; however, numerous clinical complications are associated with this treatment. As tissue engineering has developed, tissue-engineered nerve grafts (TE...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000873

    authors: Yan L,Yao Z,Lin T,Zhu Q,Qi J,Gu L,Fang J,Zhou X,Liu X

    更新日期:2017-10-18 00:00:00

  • Polarization of the human motor cortex through the scalp.

    abstract::Direct currents (DC) applied directly to central nervous system structures produce substantial and long-lasting effects in animal experiments. We tested the functional effects of very weak scalp DC (< 0.5 mA, 7 s) on the human motor cortex by assessing the changes in motor potentials evoked by transcranial magnetic br...

    journal_title:Neuroreport

    pub_type: 临床试验,杂志文章

    doi:10.1097/00001756-199807130-00020

    authors: Priori A,Berardelli A,Rona S,Accornero N,Manfredi M

    更新日期:1998-07-13 00:00:00

  • The effects of ferric iron on voltage-gated potassium currents in molluscan neurons.

    abstract::In isolated neurons of Helix pomatia, a two-microelectrode voltage clamp technique was used to study the effect of Fe3+ on voltage-gated potassium currents: a low-threshold fast-inactivating current (I(A)) and a high threshold slow-inactivating current with calcium-dependent (I(C)) and calcium-independent (I(DR)) comp...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e3282c48c1c

    authors: Bukanova JV,Solntseva EI,Skrebitsky VG

    更新日期:2007-08-27 00:00:00

  • Substantial telomere shortening in the substantia nigra of telomerase-deficient mice does not increase susceptibility to MPTP-induced dopamine depletion.

    abstract::The most important risk factor for developing Parkinson's disease (PD) is age. Aging is ascribed to different mechanisms, including telomere shortening. Telomeres consist of repetitive DNA sequences and stabilize chromosome integrity. Currently, however, the data reported on telomere shortening in PD patients are inco...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000099

    authors: Oeckl P,Scheffold A,Lechel A,Rudolph KL,Ferger B

    更新日期:2014-03-26 00:00:00

  • Metabotropic purinoreceptors in rat dorsal horn neurones: predominant dendritic location.

    abstract::Elevations of cytosolic free Ca2+ concentration ([Ca2+]i) induced by addition of ATP have been compared in rat dorsal horn neurones in slices and after their isolation. ATP application induced in neurones in situ a rise of [Ca2+]i by 201 +/- 12 nM. In Ca2+-free external solution the rise was 156 +/- 14 nM (n = 45 of 7...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200111160-00026

    authors: Kruglikov I,Shutov L,Potapenko E,Voitenko N,Kostyuk P

    更新日期:2001-11-16 00:00:00

  • Human short latency cortical responses to somatosensory stimulation. A high resolution EEG study.

    abstract::Human short-latency cortical responses to median nerve stimulation were investigated with a new high resolution electroencephalography technology that markedly enhanced spatial details of somatosensory-evoked potentials (SEPs). Maximum amplitude potentials were estimated over contralateral and/or frontal-mesial scalp ...

    journal_title:Neuroreport

    pub_type: 临床试验,杂志文章

    doi:10.1097/00001756-199710200-00011

    authors: Urbano A,Babiloni F,Babiloni C,Ambrosini A,Onorati P,Rossini PM

    更新日期:1997-10-20 00:00:00

  • Motor imagery in normal subjects and Parkinson's disease patients: an H215O PET study.

    abstract::Motor imagery paradigms can be used to investigate motor preparation. We used positron emission tomography to compare regional cerebral blood flow (rCBF) in patients with Parkinson's disease and normal controls under three conditions: rest, motor imagery and motor execution. In controls, imagery activated bilateral do...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200103260-00040

    authors: Samuel M,Ceballos-Baumann AO,Boecker H,Brooks DJ

    更新日期:2001-03-26 00:00:00

  • Functional asymmetry in primary auditory cortex for processing musical sounds: temporal pattern analysis of fMRI time series.

    abstract::Hemispheric differences in the temporal processing of musical sounds within the primary auditory cortex were investigated using functional magnetic resonance imaging (fMRI) time series analysis on a 3.0 T system in right-handed individuals who had no formal training in music. The two hemispheres exhibited a clear-cut ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e3283475828

    authors: Izumi S,Itoh K,Matsuzawa H,Takahashi S,Kwee IL,Nakada T

    更新日期:2011-07-13 00:00:00

  • Influences of encoding and retrieval on the steady-state visual evoked potential.

    abstract::The steady-state visual evoked potential (SSVEP) is a powerful tool to study basic perceptual functions in the human electroencephalogram (EEG) (e.g. selective attention). The present study aimed at finding support for the SSVEP's sensitivity to higher cognitive functions (e.g. memory). We tagged pictures of meaningle...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e3283516542

    authors: Martens U,Gert AL,Gruber T

    更新日期:2012-04-18 00:00:00

  • Sequences of cortical activation for tactile pattern discrimination using magnetoencephalography.

    abstract::To observe sequential stages in tactile pattern discrimination and their modification with and without attention, we used whole-head anatomically constrained magnetoencephalography to spatiotemporally map brain responses. Eight, normal, right-handed participants discriminated between two patterns presented on the palm...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e32832c5f65

    authors: Reed CL,Hagler DJ Jr,Marinkovic K,Dale A,Halgren E

    更新日期:2009-07-01 00:00:00

  • Brain potentials and the availability of semantic and phonological codes over time.

    abstract::ERPs were recorded from subjects performing semantic and rhyme matching tasks using either spoken words, printed words or pictures as stimuli. Mismatches enhanced N400 (in the semantic task) and N450 (in the rhyme task). Onset and peak latencies were shorter for N450 than for N400 with spoken words; this relationship ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199410270-00046

    authors: Perez-Abalo MC,Rodriguez R,Bobes MA,Gutierrez J,Valdes-Sosa M

    更新日期:1994-10-27 00:00:00

  • The BOLD response: a new look at an old riddle.

    abstract::Functional imaging has struggled for two decades to establish a quantitative link between the neuronal activity and the change in signal obtained. This review proposes a division of neuronal activity into a component relating to the electrical discharge activity and a component relating to the size of the activated ne...

    journal_title:Neuroreport

    pub_type: 杂志文章,评审

    doi:10.1097/00001756-200409150-00001

    authors: Marcar VL,Loenneker T

    更新日期:2004-09-15 00:00:00

  • BDNF mediates the neuroprotective effect of PACAP-38 on rat cortical neurons.

    abstract::In primary cultures from rat cerebral cortex, pituitary adenylate cyclase-activating polypeptide (PACAP-38) exerted a protective effect on cell death induced by the excitotoxin NMDA in neuron-enriched cultures and also on apoptotic cell death induced by serum deprivation in mixed neuronal-glial cultures. The neuroprot...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200104170-00011

    authors: Frechilla D,García-Osta A,Palacios S,Cenarruzabeitia E,Del Rio J

    更新日期:2001-04-17 00:00:00

  • Development of voltage-dependent inward currents in dissociated newt retinal pigment epithelial cells in culture.

    abstract::The whole-cell patch-clamp technique was employed to investigate the development of voltage-gated currents in cultured newt retinal pigment epithelial (RPE) cells. Freshly dissociated RPE cells were inexcitable and mainly exhibited a voltage-gated outward K+ current. Within a few days in culture RPE cells began to fla...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199404000-00020

    authors: Sakai H,Saito T

    更新日期:1994-04-14 00:00:00

  • Functional neuroimaging of attention in the auditory modality.

    abstract::Previous functional neuroimaging studies of attention have emphasized the visual modality. We developed an auditory version of the continuous performance test (CPT) that included simple, focused and divided attention conditions. Positron emission tomographic (PET) scans were acquired during CPT performance in normal y...

    journal_title:Neuroreport

    pub_type: 临床试验,杂志文章

    doi:10.1097/00001756-199801050-00024

    authors: Benedict RH,Lockwood AH,Shucard JL,Shucard DW,Wack D,Murphy BW

    更新日期:1998-01-05 00:00:00

  • Changes in spinal cholecystokinin release after peripheral axotomy.

    abstract::The gene expression of cholecystokinin (CCK), a neuropeptide with anti-opioid properties, has been reported to be upregulated in some primary sensory neurons after a peripheral nerve lesion. We have recently demonstrated that the upregulation of CCK mRNA is not accompanied by an increased potassium-evoked release CCK-...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200101220-00018

    authors: Afrah AW,Gustafsson H,Olgart L,Brodin E,Stiller CO

    更新日期:2001-01-22 00:00:00

  • Opioid receptors in the human cerebellum: evidence from [11C]diprenorphine PET, mRNA expression and autoradiography.

    abstract::Little is known regarding opioid receptors in the human cerebellum. The present [11C]diprenorphine PET study investigated opioid receptor binding in the human cerebellum in vivo, and showed a differential binding level in cerebellar cortex, vermis and dentate nuclei. The additional study in vitro of opioid receptors i...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199902250-00032

    authors: Schadrack J,Willoch F,Platzer S,Bartenstein P,Mahal B,Dworzak D,Wester HJ,Zieglgänsberger W,Tölle TR

    更新日期:1999-02-25 00:00:00

  • Gene expression in the geniculate induced by a nonphotic circadian phase shifting stimulus.

    abstract::We examined the effect of a nonphotic stimulus (running in a novel wheel) on the induction of Fos-related proteins in the two well-established neural components of the circadian clock: the suprachiasmatic nucleus (SCN) and the intergeniculate leaflet (IGL) of the lateral geniculate complex. There was no induction of F...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199207000-00007

    authors: Janik D,Mrosovsky N

    更新日期:1992-07-01 00:00:00

  • GABAergic tonic inhibition of substantia gelatinosa neurons in mouse spinal cord.

    abstract::We used whole-cell recording to identify, for the first time, GABAergic tonic current in subpopulations of substantia gelatinosa neurons in mouse spinal cord slices. Application of the gamma-aminobutyric acid type A receptor antagonist bicuculline revealed tonic currents in 49 of 73 substantia gelatinosa neurons. Thes...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/01.wnr.0000230515.86090.bc

    authors: Takahashi A,Mashimo T,Uchida I

    更新日期:2006-08-21 00:00:00

  • Polyamines modulate the function of transfected glutamate receptor mGluR1a.

    abstract::Metabotropic glutamate receptor mGluR1a was expressed in human embryonic kidney 293 cells. 1S,3R-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) stimulated dose-dependently, phosphoinositide (PI) hydrolysis in transfected, but not in non-transfected cells. The polyamine spermine did not affect PI hydrolysis in th...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199306000-00059

    authors: Manev RM,Gabellini N,Manev H

    更新日期:1993-06-01 00:00:00

  • Basal forebrain stimulation changes cortical sensitivities to complex sound.

    abstract::Experience affects how brains respond to sound. Here, we examined how the sensitivity and selectivity of auditory cortical neuronal responses were affected in adult rats by the repeated presentation of a complex sound that was paired with basal forebrain stimulation. The auditory cortical region that was responsive to...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200107200-00047

    authors: Mercado E,Bao S,Orduña I,Gluck MA,Merzenich MM

    更新日期:2001-07-20 00:00:00

  • Expression of TRPV1 in the C57BL/6 mice brain hippocampus and cortex during development.

    abstract::Transient receptor potential vanilloid 1 (TRPV1) channel has been found to be expressed in a variety of tissues over the last few years, including the central nervous system (CNS). However, the distribution of TRPV1 in the CNS remains a controversial question. Here, we reveal that the expression of TRPV1 can be detect...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000105

    authors: Huang WX,Min JW,Liu YQ,He XH,Peng BW

    更新日期:2014-04-16 00:00:00