Abstract:
:Transgenic mouse strains were generated that overexpress human APP or clinical mutants of APP. All transgenic mouse strains that over-express APP displayed essentially the same phenotype of disturbed behaviour, differential glutamatergic responses, deficits in maintenance of long-term potentiation and premature death, but formation of amyloid plaques was seen in the highest expressing APP/London transgenic mice only. Apart from cognitive deficits, the APP transgenic mice were characterized by aggressive behaviour, which was pharmacologically alleviated with 8-OH-DPAT and buspirone, two serotonergic agonists. The atypical neuroleptic drug risperidone was equally active in this regard. The data establish an important aspect of the transgenic mice as experimental models for behavioural aspects of Alzheimer's disease, in addition to other early and late symptoms.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Moechars D,Gilis M,Kuipéri C,Laenen I,Van Leuven Fdoi
10.1097/00001756-199811160-00004subject
Has Abstractpub_date
1998-11-16 00:00:00pages
3561-4issue
16eissn
0959-4965issn
1473-558Xjournal_volume
9pub_type
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