Abstract:
:Voltage-gated sodium channels (VGSCs) are concentrated in the postsynaptic membrane at the adult rat neuromuscular junction (NMJ). We have used immunolabelling to determine the pattern of initial VGSC accumulation during development. At birth, but not 3 days before, VGSC labelling is detectable at the NMJ and in the perijunctional (periJ) membrane but not elsewhere. A much higher density cluster of VGSCs forms at the NMJ itself 1-2 weeks later. If the nerve is cut 2 days after birth, VGSC labelling persists in the periJ region for at least 4 weeks but the clustering of VGSCs at the NMJ fails to develop. Thus an early, stable accumulation of VGSCs develops near the NMJ at least a week before high density postsynaptic VGSC clusters form.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Wood SJ,Shewry K,Young C,Slater CRdoi
10.1097/00001756-199806220-00014subject
Has Abstractpub_date
1998-06-22 00:00:00pages
1991-5issue
9eissn
0959-4965issn
1473-558Xjournal_volume
9pub_type
杂志文章相关文献
NEUROREPORT文献大全abstract::The distribution of c-fos proto-oncogene expression has been studied in the periaqueductal grey matter (PAG) of non-intentional-stimulated rats by immunohistochemistry. A mean number of 53 +/- 9 Fos-like immunoreactive cells per hemiPAG, distributed into three groups, dorsolateral, lateral and ventrolateral, was found...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199611040-00068
更新日期:1996-11-04 00:00:00
abstract::The aim of this study was to investigate the effects of congenital human cytomegalovirus infection on the expression levels of N-methyl-D-aspartate receptors (NRs) and Ca/calmodulin-dependent protein kinase II (CaMKII) in the hippocampal neurons of neonatal Sprague-Dawley (SD) rats. Pregnant SD rats were divided into ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000750
更新日期:2017-03-22 00:00:00
abstract::Mammalian TIMELESS (TIM) was identified due to its sequence similarity to Drosophila TIM, an essential circadian clock protein in flies. Published literature is inconsistent regarding the rhythmic expression of mammalian Tim, the interaction of the TIM protein with other clock proteins and its role in regulating clock...
journal_title:Neuroreport
pub_type: 杂志文章,评审
doi:10.1097/01.wnr.0000233092.90160.92
更新日期:2006-08-21 00:00:00
abstract::Subpopulations of olfactory receptor neurons, which are dispersed throughout the olfactory neuroepithelium, express specific cell surface carbohydrates and project to discrete regions of the olfactory bulb. Cell surface carbohydrates such as N-acetyl-lactosamine have been postulated to mediate sorting and selective fa...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199710200-00001
更新日期:1997-10-20 00:00:00
abstract::Hypoxia-inducible factor-1 (HIF-1) regulates the expression of neuroprotective genes such as erythropoietin (EPO). We investigated the mechanism by which zinc, an excitotoxin-like metal, regulates HIF-1 under hypoxic conditions in astrocytes. In hypoxic LN215 cells, HIF-1alpha stabilized and accumulated in the nucleus...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e328304d9ac
更新日期:2008-07-02 00:00:00
abstract::Calcium increases induced by single action potentials in rat visual cortex layer II/III pyramidal neurons were shown to be augmented by muscarinic acetylcholine receptor (mAchR) stimulation. This augmentation was drastically reduced by intracellular injection of heparin but not ruthenium red, therefore involving inosi...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200002280-00022
更新日期:2000-02-28 00:00:00
abstract::Brain trauma induces a multitude of reactions at molecular, cellular, and tissue levels, some of which are beneficial to recovery, whereas others are detrimental. Osteopontin (OPN), a glycosylated phosphoprotein, can be found in both the soluble form and as an extracellular matrix constituent in several tissues in the...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e328355380e
更新日期:2012-08-01 00:00:00
abstract::Expression of monocarboxylate transporter MCT1 was studied in archival tissues from human CNS using antibodies to the carboxyl-terminal end of MCT1. Sections of neocortex, hippocampus and cerebellum of brains from 10 adult autopsy patients who died from other than CNS disease, and from archival surgical biopsy specime...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200103260-00030
更新日期:2001-03-26 00:00:00
abstract::The cochlea can be protected from acoustic trauma by moderate-level sound exposure. It is suggested that olivocochlear system may play a significant role in this protection. This study was performed to investigate distortion product otoacoustic emission (DPOAE) amplitudes changes and the efficiency of contralateral no...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32820049a8
更新日期:2007-07-16 00:00:00
abstract::It is well established that re-exposure to a context paired with the effects of drugs of abuse can renew extinguished drug seeking behavior. A context, however, typically includes several stimuli, which may differ in their ability to control drug-oriented behaviors. Hence, the primary objective of this study was to as...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000084
更新日期:2014-03-26 00:00:00
abstract::While effects of attention on late and middle latency components of the evoked potential have been demonstrated, similar effects on brain stem evoked potentials--in particular on the human frequency-following potential (FFP)--are controversial. The FFP is a response to tone bursts in the frequency range of human langu...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/00001756-199408150-00017
更新日期:1994-08-15 00:00:00
abstract::It has been previously demonstrated that members of the neurotrophin family may prevent death of motoneurones following axotomy. Here we report that the expression of mRNA for full-length trkB, which is a signal transducing receptor for BDNF and NT-4, increases transiently in spinal motoneurones after axotomy in adult...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199402000-00009
更新日期:1994-02-24 00:00:00
abstract::Recent studies have discussed the role of the cerebellum in not only motor but also cognitive functions, and in particular, fronto-executive operations. Similar to a previous study on hemineglect patients, we recorded eye movements during a visual search task to investigate patients with isolated infarction of the cer...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000177015.75096.b6
更新日期:2005-09-08 00:00:00
abstract::Previous studies have shown that isosteviol sodium (STVNa) protects against permanent cerebral ischemia injury by inhibition of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB)-mediated inflammatory responses. Overwhelming evidence shows that toll-like receptors (TLRs) are the upstream regula...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001033
更新日期:2018-07-04 00:00:00
abstract::Older adults are known to gain more than younger adults from the simultaneous presentation of semantically congruent sensory stimuli. Although these findings are quite exciting, they may not solely be due to age-related differences in multisensory processing. Rather, enhanced integration may be explained by alteration...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3281e72ae7
更新日期:2007-07-02 00:00:00
abstract::Densities of serotonin transporters (5-HTT) in the postmortem neocortex of behaviorally assessed Alzheimer's disease (AD) patients and aged controls were measured by radioligand binding with [3H]citalopram. It was found that 5-HTT sites in the temporal cortex of AD patients with prominent antemortem anxiety were unalt...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000077546.91466.a8
更新日期:2003-07-18 00:00:00
abstract::Voltage-gated sodium channels consist of a pore-containing alpha-subunit and one or more auxiliary beta-subunits, which may modulate channel function. We previously demonstrated that sodium channel SNS/PN3 alpha-subunits were decreased in human sensory cell bodies after spinal root avulsion injury, and accumulated at ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200103050-00012
更新日期:2001-03-05 00:00:00
abstract::Using subtractive cloning, we identified a 1.4 kb mRNA that was ubiquitously expressed in various tissues; this mRNA was highly up-regulated in amygdala nuclei in mice when morphine was repeatedly administered but not when an opiate-receptor antagonist was co-administered. The mRNA encodes a 23 kDa protein, designated...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200211150-00018
更新日期:2002-11-15 00:00:00
abstract::Recently it has been reported that a missense G(88)C mutation within exon 3 and a missense G(209)A mutation within exon 4 of the alpha-synuclein gene were linked to familial Parkinson's Disease (PD). We decided to investigate if these and any other mutations in exons 3 and 4 of the alpha-synuclein gene could be detect...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199812010-00029
更新日期:1998-12-01 00:00:00
abstract::1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity reproduces many of the features of Parkinson's disease (PD). alpha-Synuclein has been identified as a prominent component of the Lewy body (LB), the pathological hallmark of PD. MPTP-treated primates have been reported to develop intraneuronal inclusion...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200001170-00041
更新日期:2000-01-17 00:00:00
abstract::Magnetic brain responses were recorded to clarify the cortical representation of vowel processing in Japanese. We investigated the peak latencies and equivalent current dipoles of the auditory N1m responses to the Japanese vowels [a], [i], [o], and [u]. In intraindividual analyses for a single participant, well-replic...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000230503.47973.b7
更新日期:2006-07-31 00:00:00
abstract::In this study it was shown that in adults, the frequency characteristics of EEG preceding stimuli that were followed by incorrect responses were different from the characteristics of EEG preceding stimuli that were followed by correct responses. In the recording during three different tasks that explore different neur...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200008210-00012
更新日期:2000-08-21 00:00:00
abstract::Repetitive transcranial magnetic stimulation (rTMS) has been tried therapeutically in major depression. In order to investigate the therapeutic efficacy of rTMS in psychotic patients, 12 participants (four women, eight men) with schizophrenia according to DSM-IV criteria, aged 25 to 63 years (mean (+/-s.d) 40.4+/-11.0...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00001756-200012180-00022
更新日期:2000-12-18 00:00:00
abstract::Recently, we have demonstrated that bone marrow stem cells can differentiate into retinal nerve cells. In the present study, we show a new and efficient strategy for transplanting bone marrow stem cells into the retina. When bone marrow stem cells were injected into the vitreous cavity of untreated eyes, only very few...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000176517.96475.18
更新日期:2005-08-22 00:00:00
abstract::The environment in which cocaine is experienced becomes associated with the effects of the drug and can then elicit cocaine craving. This study examined whether the hippocampus is involved in such associations using the conditioned place preference model. Rats received bilateral lesions of the dorsal or ventral hippoc...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200311140-00023
更新日期:2003-11-14 00:00:00
abstract::To clarify possible interaction between the ventral hippocampal cannabinoid CB2 receptors and the cholinergic system in control of the memory process, the effects of cannabinoid and acetylcholine receptor agents on memory consolidation have been investigated in mice. Animals implanted with bilateral cannulas at the CA...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001381
更新日期:2020-01-27 00:00:00
abstract::To test for the feature specificity of adaptation of auditory-cortex magnetoencephalographic N1m responses to phonemes during lipreading, we presented eight healthy volunteers with a simplified sine-wave first-formant (F1) transition shared by /ba/, /ga/, and /da/, and a continuum of second-formant (F2) transitions co...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3282f36f7a
更新日期:2008-01-08 00:00:00
abstract::Multiple regression voxel-based morphometry analyses were used to examine the relationship between regional gray matter volumes and neurocognitive performance in 10 patients with amnestic mild cognitive impairment and 20 healthy age-matched controls. Cognitive functioning was assessed with seven standardized neuropsyc...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e328335642a
更新日期:2010-03-10 00:00:00
abstract::We investigated the effect of previous musical training on lateralization of language as indexed by the effects of reading aloud on the modulation of motor evoked potentials (MEPs) induced in the first dorsal interosseus muscles (FDI) by transcranial magnetic stimulation (TMS) of the primary motor cortex. We studied 1...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200205070-00033
更新日期:2002-05-07 00:00:00
abstract::Inhibition, the process that overrides and reverses the execution of a thought, action, or emotion, is important in daily life. Sixteen healthy volunteers performed a parametrically modulated motor inhibition task during functional magnetic resonance imaging. Two results were observed: (1) increased error-related ante...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200505120-00020
更新日期:2005-05-12 00:00:00