Abstract:
:Densities of serotonin transporters (5-HTT) in the postmortem neocortex of behaviorally assessed Alzheimer's disease (AD) patients and aged controls were measured by radioligand binding with [3H]citalopram. It was found that 5-HTT sites in the temporal cortex of AD patients with prominent antemortem anxiety were unaltered compared with controls, but were reduced in non-anxious AD subjects. Furthermore, homozygosity for the high activity allele of a functional polymorphism in the 5-HTT gene promoter region (5-HTTLPR) was associated with both increased [3H]citalopram binding and occurrence of anxiety in the AD subjects. Since serotonin-synthesizing neurons are known to be lost in the AD cortex, this study suggests that the preservation of 5-HTT may exacerbate serotonergic deficits and underlie anxiety symptoms in AD.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Tsang SW,Lai MK,Francis PT,Wong PT,Spence I,Esiri MM,Keene J,Hope T,Chen CPdoi
10.1097/01.wnr.0000077546.91466.a8subject
Has Abstractpub_date
2003-07-18 00:00:00pages
1297-300issue
10eissn
0959-4965issn
1473-558Xjournal_volume
14pub_type
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