Abstract:
:We screened proteins for interaction with presenilin (PS) 1, and cloned the full-length cDNA of human delta-catenin, which encoded 1225 amino acids. Yeast two-hybrid assay, GST binding assay and immunoprecipitation demonstrated that delta-catenin interacted with a hydrophilic loop region in the endoproteolytic C-terminal fragment of PS1, but not with that of PS-2. These results suggest that PS1 and PS2 partly differ in function. PS1 loop fragment containing the pathogenic mutation retained the binding ability. We also found another armadillo-protein, p0071, interacted with PS1.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Tanahashi H,Tabira Tdoi
10.1097/00001756-199902250-00022subject
Has Abstractpub_date
1999-02-25 00:00:00pages
563-8issue
3eissn
0959-4965issn
1473-558Xjournal_volume
10pub_type
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