Isolation of human delta-catenin and its binding specificity with presenilin 1.

Abstract:

:We screened proteins for interaction with presenilin (PS) 1, and cloned the full-length cDNA of human delta-catenin, which encoded 1225 amino acids. Yeast two-hybrid assay, GST binding assay and immunoprecipitation demonstrated that delta-catenin interacted with a hydrophilic loop region in the endoproteolytic C-terminal fragment of PS1, but not with that of PS-2. These results suggest that PS1 and PS2 partly differ in function. PS1 loop fragment containing the pathogenic mutation retained the binding ability. We also found another armadillo-protein, p0071, interacted with PS1.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Tanahashi H,Tabira T

doi

10.1097/00001756-199902250-00022

subject

Has Abstract

pub_date

1999-02-25 00:00:00

pages

563-8

issue

3

eissn

0959-4965

issn

1473-558X

journal_volume

10

pub_type

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