Isolation of human delta-catenin and its binding specificity with presenilin 1.


:We screened proteins for interaction with presenilin (PS) 1, and cloned the full-length cDNA of human delta-catenin, which encoded 1225 amino acids. Yeast two-hybrid assay, GST binding assay and immunoprecipitation demonstrated that delta-catenin interacted with a hydrophilic loop region in the endoproteolytic C-terminal fragment of PS1, but not with that of PS-2. These results suggest that PS1 and PS2 partly differ in function. PS1 loop fragment containing the pathogenic mutation retained the binding ability. We also found another armadillo-protein, p0071, interacted with PS1.






Tanahashi H,Tabira T




Has Abstract


1999-02-25 00:00:00












  • Type I adrenal steroid receptors prolong hippocampal long-term potentiation.

    abstract::The effects of Type I adrenal steroid receptors in prolonging synaptic plasticity in the dentate gyrus of freely behaving rats was investigated. Rats were implanted with chronic, bilateral stimulating and recording electrodes in the perforant pathway and dentate gyrus, respectively, and adrenalectomized (ADX). After a...


    pub_type: 杂志文章


    authors: Pavlides C,Kimura A,Magariños AM,McEwen BS

    更新日期:1994-12-20 00:00:00

  • NMDA receptor blockade reverses motor response alterations induced by levodopa.

    abstract::Motor fluctuations that ultimately complicate the response of most parkinsonian patients to levodopa therapy might represent a form of behavioral or neuronal plasticity. Since various forms of neuronal plasticity appear to be mediated by glutamate transmission through the N-methyl-D-aspartate (NMDA) receptor, the effe...


    pub_type: 杂志文章


    authors: Engber TM,Papa SM,Boldry RC,Chase TN

    更新日期:1994-12-20 00:00:00

  • BDNF-mediated rescue of axotomized motor neurones decreases with increasing dose.

    abstract::Direct application of brain-derived neurotrophic factor (BDNF) to the cut end of axotomized immature motor neurones had only transient survival-promoting effects. Therefore, we have examined whether additional delivery of BDNF with repeated subcutaneous injections (1 mg/ml) could potentiate this short-term rescue of t...


    pub_type: 杂志文章


    authors: Vejsada R,Sagot Y,Kato AC

    更新日期:1994-10-03 00:00:00

  • Kainic acid-induced seizures activate GSK-3β in the hippocampus of D2R-/- mice.

    abstract::Dopamine D2 receptor (D2R) signalling is implicated in limbic seizure propagation and seizure-induced neurodegeneration. D2R-/- mice display increased susceptibility to kainic acid (KA) seizures and seizure-induced apoptosis of hippocampal neurons. Here we further investigated the molecular pathways of KA-induced apop...


    pub_type: 杂志文章


    authors: Tripathi PP,Santorufo G,Brilli E,Borrelli E,Bozzi Y

    更新日期:2010-08-23 00:00:00

  • N400 amplitude does not recover from disappearance after repetitions despite reinitiated semantic integration difficulty.

    abstract::It remains an open question whether the amplitude of N400 reflects combinatory postlexical semantic integration processing. To examine the issue, we repeatedly presented strictly simplified, N400-eliciting three-word structures for seven times, mixed with their plausible counterparts, followed immediately by a much mo...


    pub_type: 杂志文章


    authors: Huang Y,Jiang M,Guo Q,Yang FG

    更新日期:2018-11-07 00:00:00

  • Lack of response to epidermal growth factor in adult neural progenitor cells.

    abstract::Neural progenitor/stem cells reside in the subventricular zone and dentate gyrus of the adult rat brain, which proliferate in response to several growth factors. Here we show that the neurospheres generated from the adult dentate gyrus and subventricular zone proliferate in vitro in response to fibroblast growth facto...


    pub_type: 杂志文章


    authors: Kalluri HS,Vemuganti R,Dempsey RJ

    更新日期:2005-05-31 00:00:00

  • CO2-sensitive medullary neurons: activation by intracellular acidification.

    abstract::Bioelectric activity of CO2-sensitive, ventrolateral medullary neurons (VLN(CS)) in organotypic cultures from the obex level of newborn rats was tested during changes of the intracellular pH (pHi) measured in BCECF-AM loaded cultures. Hypercapnia (pCO2 80-100 mmHg) reduced pHi by 0.15 +/- 0.06 units and stimulated neu...


    pub_type: 杂志文章


    authors: Wiemann M,Baker RE,Bonnet U,Bingmann D

    更新日期:1998-01-05 00:00:00

  • Malonate-induced cortico-motoneuron death is attenuated by NT-4, but not by BDNF or NT-3.

    abstract::Neurotrophins are promising candidates to slow the progression of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease in which spinal and cortical motoneurons selectively degenerate. In a long-term in vitro model, malonate-induced toxicity and cell death of motoneurons have been demonstrated. Here we stud...


    pub_type: 杂志文章


    authors: Van Westerlaak MG,Bär PR,Cools AR,Joosten EA

    更新日期:2001-05-25 00:00:00

  • Neural substrates of tactile imagery: a functional MRI study.

    abstract::fMRI investigation on the neural substrates involved in tactile imagery is reported. Healthy subjects performed mental imagery of tactile stimulation on the dorsal aspect of the right hand. The results were compared with the regions of activation during the actual tactile stimulation. During imagery, contralateral pri...


    pub_type: 杂志文章


    authors: Yoo SS,Freeman DK,McCarthy JJ 3rd,Jolesz FA

    更新日期:2003-03-24 00:00:00

  • Preattentive evaluation of multiple perceptual streams in human audition.

    abstract::To analyze an auditory scene, the segregation of the input into separate streams of information is necessary. Here, the mismatch negativity (MMN) of the event-related potential was used to trace the number of simultaneously monitored streams in auditory scene analysis. Subjects passively listened to sounds belonging t...


    pub_type: 杂志文章


    authors: Nager W,Teder-Sälejärvi W,Kunze S,Münte TF

    更新日期:2003-05-06 00:00:00

  • Epidermal growth factor receptor is involved in clusterin-induced astrocyte proliferation.

    abstract::We previously reported that clusterin enhances astrocyte proliferation and extracellular signal-regulated kinase (ERK) activity. It, however, remains largely unknown how clusterin promotes cell growth. Here, we investigate the signaling pathway and related molecules underlying astrocyte proliferation by clusterin. Exo...


    pub_type: 杂志文章


    authors: Shim YJ,Shin YJ,Jeong SY,Kang SW,Kim BM,Park IS,Min BH

    更新日期:2009-03-04 00:00:00

  • Dominance for language and spatial processing: limited capacity of a single hemisphere.

    abstract::Using functional magnetic resonance imaging during word generation and spatial judgement (Landmark task), we investigated how hemispheric specializations for language and spatial processing interact in healthy individuals. We found individuals with atypical, right-hemispheric dominance for language to have more bilate...


    pub_type: 杂志文章


    authors: Jansen A,Flöel A,Menke R,Kanowski M,Knecht S

    更新日期:2005-06-21 00:00:00

  • Neuroprotective effects of 17β-estradiol associate with KATP in rat brain.

    abstract::Previous studies have indicated that estrogen protects the brain from ischemic damage and regulates K(ATP) channel activity; the present study was designed to address the involvement of K(ATP) channels in the neuroprotective effects of estrogen in focal cerebral ischemia: in experiment 1, K(ATP) mRNA and protein in th...


    pub_type: 杂志文章


    authors: Zhang D,Xia H,Xu L,Zhang C,Yao W,Wang Y,Ren J,Wu J,Tian Y,Liu W,Wang X

    更新日期:2012-11-14 00:00:00

  • Spinal cord stimulation postconditioning reduces microglial activation through down-regulation of ERK1/2 phosphorylation during spinal cord ischemic reperfusion in rabbits.

    abstract::Microglial activation plays a critical role in spinal cord ischemic reperfusion injury. Spinal cord stimulation preconditioning and postconditioning has shown spinal cord protection in ischemic reperfusion injury in animal studies. However, whether spinal cord stimulation could reduce microglial activation is still un...


    pub_type: 杂志文章


    authors: Dong X,Li H,Lu J,Yang Y,Jing H,Cheng Y,Jin M,Cheng W

    更新日期:2018-09-26 00:00:00

  • Neural mechanisms of the octave illusion: electrophysiological evidence for central origin.

    abstract::The octave illusion is experienced when two simultaneous tones, separated by one octave and presented to the opposite ears, are continuously reversed between the two ears. Subjects consistently report a sequence of alternating single tones: the high tone in the right ear and the low in the left. We wished to determine...


    pub_type: 临床试验,杂志文章


    authors: Ross J,Tervaniemi M,Näätänen R

    更新日期:1996-12-20 00:00:00

  • Auditory stimuli activate parietal brain regions: a whole-head MEG study.

    abstract::Previous studies using magnetoencephalographic (MEG) recordings have revealed neuronal populations responding to discrete auditory stimuli in the supratemporal cortex of the human brain. We used the novel whole-head magnetometer (Neuromag-122) to determine whether regions outside the auditory cortex are activated by a...


    pub_type: 杂志文章


    authors: Lavikainen J,Huotilainen M,Pekkonen E,Ilmoniemi RJ,Näätänen R

    更新日期:1994-12-30 00:00:00

  • Epigenetic upregulation of Cdk5 in the dorsal horn contributes to neuropathic pain in rats.

    abstract::Numerous reports have shown that cyclin-dependent kinase 5 (Cdk5), a proline-directed serine/threonine kinase, critically contributes to the induction and maintenance of chronic pain induced by peripheral inflammation and nerve injury. Recent evidence has also suggested the critical role of an epigenetic mechanism in ...


    pub_type: 杂志文章


    authors: Li K,Zhao GQ,Li LY,Wu GZ,Cui SS

    更新日期:2014-10-01 00:00:00

  • Structural and functional connectivity correlates with motor impairment in chronic supratentorial stroke: a multimodal magnetic resonance imaging study.

    abstract::The aim of this study was to identify differences in structural and functional brain connectivity between poststroke mild and severe motor impairment. Twenty-four chronic stroke patients who underwent resting-state functional MRI and diffusion tensor image were retrospectively included. All patients were classified in...


    pub_type: 杂志文章


    authors: Lee JH,Kyeong S,Kang H,Kim DH

    更新日期:2019-05-01 00:00:00

  • Neural processes underlying perceptual enhancement by visual speech gestures.

    abstract::This fMRI study explores brain regions involved with perceptual enhancement afforded by observation of visual speech gesture information. Subjects passively identified words presented in the following conditions: audio-only, audiovisual, audio-only with noise, audiovisual with noise, and visual only. The brain may use...


    pub_type: 杂志文章


    authors: Callan DE,Jones JA,Munhall K,Callan AM,Kroos C,Vatikiotis-Bateson E

    更新日期:2003-12-02 00:00:00

  • Regulation of vasoactive intestinal polypeptide release in the suprachiasmatic nucleus circadian clock.

    abstract::Timing of the mammalian circadian clock of the suprachiasmatic nucleus (SCN) is regulated by photic input from the retina. Retinorecipient units entrain rhythmicity of SCN pacemaker cells in part through their release of vasoactive intestinal polypeptide (VIP). The underlying nature of this process is conjectural, how...


    pub_type: 杂志文章


    authors: Francl JM,Kaur G,Glass JD

    更新日期:2010-11-17 00:00:00

  • Retinal ganglion cell axons regenerate in the presence of intact sensory fibres.

    abstract::A novel allograft paradigm was used to test whether adult mammalian central axons regenerate within a peripheral nerve environment containing intact sensory axons. Retinal ganglion cell axon regeneration was compared following anastomosis of dorsal root ganglia grafts or conventional peripheral nerve grafts to the adu...


    pub_type: 杂志文章


    authors: King C,Bartlett C,Sauvé Y,Lund R,Dunlop S,Beazley L

    更新日期:2006-02-06 00:00:00

  • No association of spastic paraparesis genes in PSEN1 Alzheimer's disease with spastic paraparesis.

    abstract::Familial Alzheimer's disease due to presenilin 1 (PSEN1) mutations shows considerable phenotypic variability with differences in neuropathology and neurological symptoms. Spastic paraparesis is a common neurological phenotype associated with Alzheimer's disease arising from PSEN1 mutations. To investigate whether know...


    pub_type: 杂志文章


    authors: Karlstrom H,Kwok JB,Gregory GC,Hallupp M,Brooks WS,Schofield PR

    更新日期:2007-08-06 00:00:00

  • Human thalamus: neurochemical mapping of inferior pulvinar complex.

    abstract::The primate pulvinar connects with the entire array of known visual areas and is postulated to play a role in selective visual attention. Recently, five separate neurochemical subdivisions of a region termed the inferior pulvinar (PI) complex were identified in monkeys. In the present study, similar histochemical proc...


    pub_type: 杂志文章


    authors: Cola MG,Gray DN,Seltzer B,Cusick CG

    更新日期:1999-12-16 00:00:00

  • Expression of α-gustducin in mammalian retinas.

    abstract::α-Gustducin (Gα-gust) is the α subunit of the heterotrimeric G-protein complex specific for taste receptor cells of the tongue. However, it has been shown to be present in ectopic regions, such as airways and digestive tract. Recently, Gα-gust was found within neurons in various regions of the mouse brain. In this stu...


    pub_type: 杂志文章


    authors: Son MJ,Hu YJ,Kim SA,Chun MH,Kim IB,Kim MS

    更新日期:2011-02-16 00:00:00

  • Interindividual and interspecies variations of the extrastriate visual cortex.

    abstract::Functional homology between human and macaque visual cortices has provided an important cue to functional subdivisions of the human visual cortex, but it is unclear beyond V1. We estimated the sizes and the visual field eccentricity functions of the extrastriate visual areas of human brains using MRI and fMRI measurem...


    pub_type: 杂志文章


    authors: Ejima Y,Takahashi S,Yamamoto H,Fukunaga M,Tanaka C,Ebisu T,Umeda M

    更新日期:2003-08-26 00:00:00

  • Distinct anxiogenic/anxiolytic effects exerted by the hamster lateral amygdalar nucleus injected with ORX-A or ORX-B in the presence of a GABAergic agonist.

    abstract::Recently, there has been growing interest in the neurobiological role of some amygdalar neuromediators, such as GABA and orexins (ORX), that are responsible for stressful behaviors. Infusion of the major fear-related and panic-related basolateral amygdalar station, the lateral nucleus, with ORX-A and ORX-B, alone or i...


    pub_type: 杂志文章


    authors: Avolio E,Biasone A,Mele M,Alò R

    更新日期:2014-08-20 00:00:00

  • The behavioral effects of bilateral middle cerebral artery hemorrhagic ischemia in rat.

    abstract::After learning position discrimination in a T-maze water escape task, rats had either a 2 mm section of the middle cerebral artery removed bilaterally (bMCA) or they received a sham operation. Beginning on the day of surgery either total brain gangliosides (50 mg kg-1) or saline were administered daily for five days. ...


    pub_type: 杂志文章


    authors: McDaniel WF,Fjordbak T,Schmidt MS,Tucker JC,Davis BK

    更新日期:1991-11-01 00:00:00

  • Neural processing of illusory and real contours revealed by high-density ERP mapping.

    abstract::Event-related potential (ERP) studies have shown that responses to illusory (IC), as compared to no contours (NC), may differ within 200 ms following stimulus presentation. However, whether these responses reflect the modulation of similar, or the activation of distinct brain regions has never been assessed. Using ERP...


    pub_type: 杂志文章


    authors: Pegna AJ,Khateb A,Murray MM,Landis T,Michel CM

    更新日期:2002-05-24 00:00:00

  • Anterior cingulate reflects susceptibility to framing during attractiveness evaluation.

    abstract::Human cognitive decisions can be strongly susceptible to the manner in which options are presented ('framing effect'). Here we investigated the neural basis of response adjustments induced by changing frames during intuitive decisions. Evidence exists that the anterior cingulate cortex plays a general role in behavior...


    pub_type: 杂志文章


    authors: Deppe M,Schwindt W,Pieper A,Kugel H,Plassmann H,Kenning P,Deppe K,Ringelstein EB

    更新日期:2007-07-16 00:00:00

  • Age-dependent changes in distribution of P3a/P3b amplitude and thickness of the cerebral cortex.

    abstract::With increasing age, the electrophysiological event-related potentials P3a/P3b tend to get a more frontal maximum. The cognitive significance of this so-called frontal shift is not known, but hypotheses have focused on changes in the integrity of the frontal lobes. The aim of the present study was to test how the thic...


    pub_type: 杂志文章


    authors: Fjell AM,Walhovd KB,Reinvang I

    更新日期:2005-09-08 00:00:00