Complete mutism after midbrain periaqueductal gray lesion.

Abstract:

:Several neurophysiological studies have highlighted the role of the midbrain periaqueductal gray matter (PAG) in the initiation of vocalization in various animal species, from frogs to primates. With regard to humans, only two cases of complete mutism following a lesion to the PAG have been reported so far. This article describes a new case of a patient (GM) who, following an ischemic lesion to the periaqueductal gray region of the midbrain, presented with complete and irreversible mutism, though her language comprehension functions and her non-verbal expression capacity were preserved. This clinical case provides evidence that in humans the PAG also acts as a link between different vocalization-eliciting external and internal stimuli (which reach the PAG from sensory and emotional structures) and the vocal-motor coordinating mechanisms in the lower brain stem.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Esposito A,Demeurisse G,Alberti B,Fabbro F

doi

10.1097/00001756-199903170-00004

subject

Has Abstract

pub_date

1999-03-17 00:00:00

pages

681-5

issue

4

eissn

0959-4965

issn

1473-558X

journal_volume

10

pub_type

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