Mouse hippocampo-prefrontal paired-pulse facilitation and long-term potentiation in vivo.

Abstract:

:To confirm neural plasticity of the mouse hippocampo-prefrontal cortex (PFC) pathway, paired-pulse facilitation (PPF) and long-term potentiation (LTP) induction were determined in the pathway. In addition, we tested whether the plasticity differs in projections of the pathway from the dorsal (upper) and ventral (lower) parts of the temporal hippocampus. The results showed PPF and LTP of this pathway, and these differed between the projections. The projection from the upper part showed stronger PPF and weaker LTP compared with that from the lower part. These results suggest that the mouse hippocampo-PFC pathway is involved in learning and memory, and contains projections related to different functions.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Izaki Y,Takita M,Nomura M

doi

10.1097/00001756-200105080-00028

subject

Has Abstract

pub_date

2001-05-08 00:00:00

pages

1191-3

issue

6

eissn

0959-4965

issn

1473-558X

journal_volume

12

pub_type

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