Abstract:
:Immunohistochemistry for calcitonin gene-related peptide (CGRP) was performed on the dorsal root ganglion (DRG) and spinal cord in wildtype and knockout mice for Brn-3a. CGRP-immunoreactive (-IR) neurons were abundant in the DRG of wildtype, heterozygous and knockout mice. Cell size analysis revealed that CGRP-IR neurons were of various sizes in wildtype and heterozygous mice. In the knockout mice, however, most of CGRP-IR neurons were small. In the spinal cord of knockout mice, the number of CGRP-IR fibers increased in the dorsal column but decreased in the deep part of the dorsal horn. The loss of Brn-3a may have different effects on CGRP-IR expression in small and large DRG neurons.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Ichikawa H,Yamaai T,Mo Z,Xiang M,Sugimoto Tdoi
10.1097/00001756-200203250-00009subject
Has Abstractpub_date
2002-03-25 00:00:00pages
409-12issue
4eissn
0959-4965issn
1473-558Xjournal_volume
13pub_type
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