Abstract:
:The effects of 8-OH-DPAT were investigated on food intake in food-deprived rats in both non-operant and operant feeding paradigms. 8-OH-DPAT produced dose-related reductions in food intake in both paradigms. While the higher doses of 8-OH-DPAT used in this study (i.e. 125-500 micrograms kg-1) produced a number of stereotyped behaviours which may have interfered with normal feeding, these behaviours were not apparent with the lower doses (i.e. 15.625-62.5 micrograms kg-1) which also depressed food-intake. The results of this study thus suggest that the inhibitory effect of 8-OH-DPAT on feeding in food-deprived rats is not secondary to the induction of stereotypy.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Ebenezer ISdoi
10.1097/00001756-199211000-00019subject
Has Abstractpub_date
1992-11-01 00:00:00pages
1019-22issue
11eissn
0959-4965issn
1473-558Xjournal_volume
3pub_type
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