Abstract:
:A bilateral spino-bulbo-spinal circuit conveys information from/to the male urogenital tract and perineal muscles. This is the first electrophysiological report of another descending pathway, one which conveys output from the medullary reticular formation (MRF) to activate postganglionic sympathetic fibers contained within the motor branch of the pudendal nerve (PudM). In anesthetized rats, long latency (> 150 ms) discharges were elicited in the PudM following ipsilateral or contralateral microstimulation of the MRF. These firing bursts were not observed in rats after sectioning the lower lumbar sympathetic trunk. The most robust activation was observed when neurons in or near the lateral paragigantocellular reticular nucleus were microstimulated bilaterally. Urogenital dysfunction that occurs following severe spinal cord injury probably results from disrupting these and other supraspinal circuits.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Johnson RD,Hubscher CHdoi
10.1097/00001756-200002070-00031subject
Has Abstractpub_date
2000-02-07 00:00:00pages
379-82issue
2eissn
0959-4965issn
1473-558Xjournal_volume
11pub_type
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